Maternal serum hepcidin is low at term and independent of cord blood iron status

Rehu, Mari; Punnonen, Kari; Ostland, V. E.; Heinonen, Seppo; Westerman, Mark; Pulkki, Kari; Sankilampi, Ulla

doi:10.1111/j.1600-0609.2010.01479.x

Cited by 107 publications

(150 citation statements)

References 36 publications

(40 reference statements)

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“…Consistent with prior investigations, cord hepcidin had a positive, dose-response relationship with cord ferritin . 40,41 The positive association between cord hepcidin and placental levels of soluble transferrin receptor was initially unexpected given earlier findings of an inverse association from the transgenic Thep27 mouse line, in which fetal hepcidin from constitutively hepcidin-expressing offspring was shown to downregulate placental transferrin receptor mRNA. 42 However, further investigation showed that high (i.e., above median) placental levels of soluble transferrin receptor were coincident with lowered maternal ferritin (P = 0.019, Wilcoxon rank-sum test) and normal cord ferritin (P = 0.48, Wilcoxon rank sum test), suggesting that the elevated placental soluble transferrin receptor could be, as previously described, a compensatory mechanism by which the placentas of iron-depleted mothers may enhance transfer of iron to the fetuses despite maternal iron deficiency, thereby mediating conflicting maternal-fetal iron demands.…”

Section: Discussionmentioning

confidence: 98%

Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study

Brickley

Spottiswoode

Kabyemela

et al. 2016

The American Journal of Tropical Medicine and Hygiene

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Abstract. Hepcidin, the master regulator of bioavailable iron, is a key mediator of anemia and also plays a central role in host defense against infection. We hypothesized that measuring hepcidin levels in cord blood could provide an early indication of interindividual differences in iron regulation with quantifiable implications for anemia, malaria, and mortality-related risk. Hepcidin concentrations were measured in cord plasma from a birth cohort (N = 710), which was followed for up to 4 years in a region of perennial malaria transmission in Muheza, Tanzania (2002Tanzania ( -2006. At the time of delivery, cord hepcidin levels were correlated with inflammatory mediators, iron markers, and maternal health conditions. Hepcidin levels were 30% (95% confidence interval [CI]: 12%, 44%) lower in children born to anemic mothers and 48% (95% CI: 11%, 97%) higher in placental malaria-exposed children. Relative to children in the lowest third, children in the highest third of cord hepcidin had on average 2.5 g/L (95% CI: 0.1, 4.8) lower hemoglobin levels over the duration of follow-up, increased risk of anemia and severe anemia (adjusted hazard ratio [HR]

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Section: Discussionmentioning

confidence: 98%

Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study

Brickley

Spottiswoode

Kabyemela

et al. 2016

The American Journal of Tropical Medicine and Hygiene

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“…Hepcidin concentrations have not been consistently compared between races and there are few studies in children (113)(114)(115)(116)(117)(118)(119)(120). To the best of our knowledge there are 2 reported studies of hepcidin concentrations in pregnant women, both of which showed that hepcidin concentrations in anemic pregnant women is lower than in nonanemic pregnant women, but are not related to cord-blood or newborn hepcidin or other fetal iron parameters (114,121 ).…”

Section: Reference Intervals For Serum Hepcidinmentioning

confidence: 99%

Hepcidin in Human Iron Disorders: Diagnostic Implications

et al. 2011

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BACKGROUND:The peptide hormone hepcidin plays a central role in regulating dietary iron absorption and body iron distribution. Many human diseases are associated with alterations in hepcidin concentrations. The measurement of hepcidin in biological fluids is therefore a promising tool in the diagnosis and management of medical conditions in which iron metabolism is affected.CONTENT: We describe hepcidin structure, kinetics, function, and regulation. We moreover explore the therapeutic potential for modulating hepcidin expression and the diagnostic potential for hepcidin measurements in clinical practice.

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“…Hepcidin is the master regulator of iron homeostasis, and the production of this hormone is known to be regulated by iron stores, inflammation, hypoxia, and erythropoietic activity (9). Despite its crucial role in regulation of iron homeostasis, currently, little is known about fetal hepcidin production and its regulatory function, and few normative hepcidin data are available in maternal-neonatal pairs at birth (10)(11)(12).…”

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confidence: 99%

Prevalence of anemia and associations between neonatal iron status, hepcidin, and maternal iron status among neonates born to pregnant adolescents

et al. 2015

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ArticlesBackground: Little is known about anemia and iron status in US newborns because screening for anemia is typically not undertaken until 1 y of age. This study was undertaken to characterize and identify determinants of iron status in newborns born to pregnant adolescents. Methods: Pregnant adolescents (≤ 18 y, n = 193) were followed from ≥ 12 wk gestation until delivery. Hemoglobin, ferritin, soluble transferrin receptor, serum iron, hepcidin, erythropoietin (EPO), IL-6, and C-reactive protein were assessed in maternal and cord blood. results: At birth, 21% of the neonates were anemic (Hb < 13.0 g/dl) and 25% had low iron stores (ferritin < 76 µg/l). Cord serum ferritin concentrations were not significantly associated with gestational age (GA) at birth across the range of 37-42 wk. Neonates born to mothers with ferritin < 12 µg/l had significantly lower ferritin (P = 0.003) compared to their counterparts. Hepcidin and IL-6 were significantly (P < 0.05) higher in neonates born to mothers with longer durations of active labor. conclusion: Given the importance of the iron stores at birth on maintenance of iron homeostasis over early infancy, additional screening of iron status at birth is warranted among those born to this high risk obstetric population.

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Maternal serum hepcidin is low at term and independent of cord blood iron status

Abstract: At term pregnancy, hepcidin concentrations are very low, allowing maximal availability of iron for the fetus. Maternal and cord blood hepcidin levels were independently associated with either maternal or cord blood iron status.

Cited by 107 publications

References 36 publications

Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study

Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study

Hepcidin in Human Iron Disorders: Diagnostic Implications

Prevalence of anemia and associations between neonatal iron status, hepcidin, and maternal iron status among neonates born to pregnant adolescents

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