Hepcidin in Human Iron Disorders: Diagnostic Implications

Kroot, Joyce J.C.; Tjalsma, Harold; Fleming, Robert E.; Swinkels, Dorine W.

doi:10.1373/clinchem.2009.140053

Cited by 217 publications

(237 citation statements)

References 222 publications

(287 reference statements)

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“…2,[14][15][16] In this study, severe anaemia and minimally reduced ferritin levels (i.e. <324 mg/l) are associated with increased oral iron prescription by GPs.…”

Section: Comparison With Existing Literaturementioning

confidence: 99%

“…[7][8][9][10][11][12][13] ACD is described as a functional iron deficiency caused by elevated hepcidin levels, which implies that oral iron supplementation is unnecessary. [14][15][16] Patients with ACD aged 50 years have a relative risk for mortality of 1.48 compared to adults without anaemia. 17 To ensure proper treatment of ACD, the underlying cause needs to be elucidated and treated.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostics in anaemia of chronic disease in general practice: a real-world retrospective cohort study

Schop

Stouten

Houten³

et al. 2018

BJGP Open

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“…2,[14][15][16] In this study, severe anaemia and minimally reduced ferritin levels (i.e. <324 mg/l) are associated with increased oral iron prescription by GPs.…”

Section: Comparison With Existing Literaturementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diagnostics in anaemia of chronic disease in general practice: a real-world retrospective cohort study

Schop

Stouten

Houten³

et al. 2018

BJGP Open

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“…It has been suggested that the transcriptional regulators related to genes involved in circadian rhythm (upstream stimulatory factor 1 (USF1) and USF2), are potentially significant modulators of hepcidin expression (26,27). Furthermore, diurnal variation in hepcidin might also be secondary to innate circadian rhythm of one of the many biological determinants of serum hepcidin concentrations (3,11). The absence of this circadian rhythm in hepcidin concentrations in preterm infants warrants further investigation.…”

Section: Articlesmentioning

confidence: 99%

“…Hepcidin, a peptide hormone produced mainly in the liver, plays a central role in the regulation of iron absorption and body iron distribution (3). Hepcidin binds to the iron-transporting protein ferroportin, causing its internalization and degradation, thereby decreasing iron transfer from hepatocytes, macrophages, and absorptive enterocytes to the blood (4).…”

Section: Introductionmentioning

confidence: 99%

Serum hepcidin in infants born after 32 to 37 wk of gestational age

et al. 2015

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Background: Preterm infants are at risk of iron deficiency (ID). Hepcidin has been suggested as a good additional indicator of ID in preterm infants, next to ferritin. Methods: In a prospective observational study, we analyzed serum hepcidin in 111 infants born after 32+0 to 36+6 wk gestational age during the first 4 mo of life. results: Hepcidin concentrations decreased during the first 4 mo of life, and concentrations were lower in infants with ID compared to those without ID. Infants who developed ID at the age of 4 mo had already significantly lower levels of hepcidin at 1.5 mo of age, while ferritin was already significantly lower at the age of 1 wk. conclusion: Hepcidin concentrations of late preterm infants decrease during the first 4 mo of life. This decrease, which parallels a decrease of ferritin concentration, we interpret as a physiological response, aiming to increase iron availability. Hepcidin concentrations are lower in infants with ID compared with those without ID, with a notable change already observed at 1.5 mo of age. Hepcidin can be used as an early marker of ID, although an additive value of hepcidin over ferritin in the diagnosis of ID is not present.

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“…Los escasos estudios realizados en humanos se han orientado a la determinación de hepcidina en pacientes con algún trastorno del metabolismo del hierro (24,25,26) y otros realizados en personas sanas, pero que no hacen una adecuada diferenciación por ciertos grupos (12,27,28).…”

Section: Introductionunclassified

Hepcidina y parámetros del hierro en donantes de sangre

Murillo-Ramos

Hurtado-Florez²,

Arciniegas-Yampuezán³

et al. 2016

CES Med

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ResumenIntroducción: la hepcidina es la principal hormona peptídica reguladora de la absorción y distribución tisular del hierro. Estudios recientes han planteado la posibilidad de utilizarla como un biomarcador para evaluar el metabolismo del hierro y sus posibles alteraciones. Aunque, ante la escasa información sobre las propiedades diagnósticas de la hepcidina sérica, no han sido bien caracterizadas y no se cuenta con estudios suficientes en individuos sanos, e incluso en Colombia hasta el momento no se ha realizado ningún estudio referente al tema. Objetivo: estimar las concentraciones de la hepcidina sérica, su rango de normalidad y su correlación con parámetros bioquímicos asociados al metabolismo del hierro en una población de donantes. Materiales y métodos: estudio descriptivo transversal que incluyó 85 donantes, a quienes se les realizó hemograma automatizado, se evaluó ferritina, transferrina y hierro total, mediante los mé-todos de electroquimioluminiscencia, inmunoturbidimetría y colorimetría. La determinación de hepcidina en suero se realizó por medio de una ELISA competitiva. Se utilizaron pruebas estadísticas, con un nivel de significancia de p< 0,05. Resultados: se observaron diferencias significativas en la concentración de hepcidina entre hombres y mujeres. La edad no fue un factor determinante de las concentraciones de hepcidina en los hombres Mediana (Me)=5,73 nM. Solo ferritina se correlacionó fuertemente con la hepcidina. El rango de normalidad de hepcidina encontrado en hombres estuvo entre 1,71 y 13,3 nM y entre 1,67 a 11,3 nM en mujeres. Conclusión: el nivel de hepcidina sérica es mayor en hombres y demuestra la fuerte asociación in vivo con los niveles de hepcidina sérica con el hierro de reserva y circulante.Palabras claves: Metabolismo del hierro, Hepcidina, Ferritina , Transferrina, Hierro total. AbstractIntroduction: The hepatic peptide hormone hepcidin is the principal regulator of iron absorption and tissue iron distribution. Recent studies have proposed hepcidin as a suitable biomarker to assess iron metabolism and its failures. Although the data were limited to information on the diagnostic properties of serum hepcidin, have not been well characterized and neither have enough studies in healthy individuals, and even in Colombia so far have not been any studies on the topic. Objective: quantify the concentra-

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Hepcidin in Human Iron Disorders: Diagnostic Implications

Cited by 217 publications

References 222 publications

Diagnostics in anaemia of chronic disease in general practice: a real-world retrospective cohort study

Diagnostics in anaemia of chronic disease in general practice: a real-world retrospective cohort study

Serum hepcidin in infants born after 32 to 37 wk of gestational age

Hepcidina y parámetros del hierro en donantes de sangre

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