Maternal pregnancy events and exposures and risk of hepatoblastoma: A Children's Oncology Group (COG) study

Musselman, Jessica R.B.; Georgieff, Michael; Ross, Julie A.; Tomlinson, Gail E.; Feusner, James; Krailo, Mark; Spector, Logan G.

doi:10.1016/j.canep.2012.12.005

Cited by 20 publications

(23 citation statements)

References 12 publications

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“…15,16 Prepregnancy BMI and pregnancy weight gain have been found to correlate with maternal prenatal hormone levels [17][18][19][20] and hormonemediated cancer risk in offspring. 11,12,14,21,22 Data from the Utah Pregnancy Risk Assessment Monitoring System from 2000 through 2005 indicate a 19% rise in excessive pregnancy weight gain 23 ; these data also show that during the same time period, the proportion of women who were obese before pregnancy rose 25%. 24 Maternal BMI and gestational weight gain have previously been associated with increased risk for developmental disability.…”

Section: What This Study Addsmentioning

confidence: 88%

“…[10][11][12][13][14] Steroid dysregulation characterizes the most common metabolic syndrome among reproductive-aged women, polycystic ovary syndrome, in which 40% to 80% of those affected experience excess weight. 15,16 Prepregnancy BMI and pregnancy weight gain have been found to correlate with maternal prenatal hormone levels [17][18][19][20] and hormonemediated cancer risk in offspring.…”

Section: What This Study Addsmentioning

confidence: 99%

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Maternal Prenatal Weight Gain and Autism Spectrum Disorders

Bilder

Bakian²,

Viskochil³

et al. 2013

Pediatrics

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Section: What This Study Addsmentioning

confidence: 88%

Section: What This Study Addsmentioning

confidence: 99%

Maternal Prenatal Weight Gain and Autism Spectrum Disorders

Bilder

Bakian²,

Viskochil³

et al. 2013

Pediatrics

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“…We previously have described in detail the methods used in the COG case control study [Musselman et al, 2013; Puumala et al, 2012]. Hepatoblastoma cases were diagnosed at a COG institution between 2000 and 2008.…”

Section: Methodsmentioning

confidence: 99%

Congenital abnormalities and hepatoblastoma: A report from the Children's Oncology Group (COG) and the Utah Population Database (UPDB)

Venkatramani

Spector

Georgieff

et al. 2014

American J of Med Genetics Pt A

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Beckwith-Wiedemann Syndrome (BWS) and Familial Adenomatous Polyposis (FAP) are known to predispose to hepatoblastoma (HB). A case control study was conducted through the Children’s Oncology Group (COG) to study the association of HB with isolated congenital abnormalities. Cases (N = 383) were diagnosed between 2000 and 2008. Controls (N = 387) were recruited from state birth registries, frequency matched for sex, region, year of birth, and birth weight. Data on congenital abnormalities among subjects and covariates were obtained by maternal telephone interview. Odds ratios (OR) and 95% confidence intervals (CI) describing the association between congenital abnormalities with HB, adjusted for sex, birth weight, maternal age and maternal education, were calculated using unconditional logistic regression. There was a significant association of HB with kidney, bladder, or sex organ abnormalities (OR = 4.75; 95% CI: 1.74–13) which appeared to be specific to kidney/bladder defects (OR = 4.3; 95% CI: 1.2–15.3) but not those of sex organs (OR = 1.24; 95% CI: 0.37–4.1). Elevated but non-significant ORs were found for spina bifida or other spinal defects (OR = 2.12; 95% CI: 0.39–11.7), large or multiple birthmarks (OR = 1.33; 95% CI: 0.81–2.21). The results were validated through the Utah Population Database (UPDB), a statewide population-based registry linking birth certificates, medical records, and cancer diagnoses. In the UPDB, there were 29 cases and 290 population controls matched 10:1 on sex and birth year. Consistent with the COG findings, kidney/bladder defects were associated with hepatoblastoma. These results confirm the association of HB with kidney/bladder abnormalities.

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“…Characteristics of the study population and design have been previously reported (17, 18). Cases were identified through the Children’s Oncology Group (COG).…”

Section: Methodsmentioning

confidence: 99%

Parental Tobacco and Alcohol Use and Risk of Hepatoblastoma in Offspring: A Report from the Children's Oncology Group

Johnson

Williams

Ross

et al. 2013

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Hepatoblastoma (HB) is a rare pediatric liver tumor that has significantly increased in incidence over the last several decades. The International Agency for Cancer Research (IARC) recently classified HB as a tobacco-related cancer. Parental alcohol use has shown no association. We examined associations between parental tobacco and alcohol use around the time of pregnancy and HB in a large case-control study. Methods Maternal interviews were completed for 383 cases diagnosed in the U.S. during 2000–2008. Controls (n=387) were identified through U.S. birth registries and frequency-matched to cases on birth weight, birth year, and region of residence. We employed unconditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between parental smoking and maternal drinking and offspring HB. Results We found no association between HB and maternal smoking at any time (OR=1.0; 95% CI=0.7–1.4), within the year before pregnancy (OR=1.1; 95% CI=0.8–1.6), early in pregnancy (OR=1.0; 95% CI=0.7–1.6), or throughout pregnancy (OR=0.9; 95% CI=0.5–1.6). We observed marginally positive associations between HB and paternal smoking in the year before pregnancy (OR=1.4; 95% CI=1.0–2.0) and during pregnancy (OR=1.4; 95% CI=0.9–2.0). Maternal alcohol use was not associated with HB. Conclusion Our results do not provide evidence for an etiological relationship between maternal smoking or drinking and HB, and only weak evidence for an association for paternal smoking in the year before pregnancy. Impact Our study provides limited support for HB as a tobacco-related cancer; however, it remains wise to counsel prospective parents on the merits of smoking cessation.

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Maternal pregnancy events and exposures and risk of hepatoblastoma: A Children's Oncology Group (COG) study

Cited by 20 publications

References 12 publications

Maternal Prenatal Weight Gain and Autism Spectrum Disorders

Maternal Prenatal Weight Gain and Autism Spectrum Disorders

Congenital abnormalities and hepatoblastoma: A report from the Children's Oncology Group (COG) and the Utah Population Database (UPDB)

Parental Tobacco and Alcohol Use and Risk of Hepatoblastoma in Offspring: A Report from the Children's Oncology Group

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