Maternal obesity influences the endocrine cord blood profile of their offspring

Mocarzel, Carolina Carvalho; Velarde, Guillermo Coca; Antunes, Roberto de Azevedo; Sá, Renato Augusto Moreira de; Kurjak, Asim

doi:10.1515/jpm-2019-0387

Cited by 6 publications

(5 citation statements)

References 34 publications

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“…We did not observe a significant correlation between pre-pregnancy BMI and cord blood glucose levels, yet a significant link has been reported previously for cord glucose levels of neonates born to obese mothers ( Mocarzel et al, 2020a ). In a cross-sectional case control study investigating offspring from obese mothers (n = 41) and healthy controls (n = 31) it was shown that cord blood glucose levels of newborns of obese mothers [47.8 mg/dL (SD 33.1)] were lower than that in the control group [57.9 mg/dL (SD 12.5)] ( Mocarzel et al, 2020b ).…”

Section: Discussioncontrasting

confidence: 74%

“…In addition, GGT is an important factor in the detoxification of xenobiotics and pollutants ( Lee and Jacobs, 2009 , Weinmayr, 2019 ), therefore, seems to occupy a key position in the interface between environmental exposures and metabolic outcomes. The maternal pre-pregnancy body mass index (BMI) may influence the child's metabolic status, as newborn metabolic signatures characteristic of insulin resistance and risk of type 2 diabetes in adults ( Lowe et al, 2017 , Mocarzel et al, 2020a , Shokry et al, 2019 ) and changes in the concentration of lipophilic xenobiotics ( Erkin-Cakmak et al, 2015 , Wolff et al, 2007 ) have been shown to coincide with a higher maternal pre-pregnancy BMI.…”

Section: Introductionmentioning

confidence: 99%

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In utero exposure to parabens and early childhood BMI z-scores – Associations between placental ethyl paraben, longitudinal BMI trajectories and cord blood metabolic biomarkers

Reimann

Vrijens

Roels

et al. 2021

Environment International

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Section: Discussioncontrasting

confidence: 74%

Section: Introductionmentioning

confidence: 99%

In utero exposure to parabens and early childhood BMI z-scores – Associations between placental ethyl paraben, longitudinal BMI trajectories and cord blood metabolic biomarkers

Reimann

Vrijens

Roels

et al. 2021

Environment International

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“…Regarding total cholesterol in the cord blood, we detected no significant differences between the samples from the offspring of normal-weight and overweight/obese groups. Consistent data were shown in a previous study [37]. Also in good agreement with a previous study [38], we observed that triglyceride levels were increased in the offspring of overweight/obese mothers.…”

Section: Discussionsupporting

confidence: 93%

Obesity Affects Maternal and Neonatal HDL Metabolism and Function

Stadler

Poppel²,

Wadsack³

et al. 2023

Antioxidants

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Pregravid obesity is one of the major risk factors for pregnancy complications such as gestational diabetes mellitus (GDM) and an increased risk of cardiovascular events in children of affected mothers. However, the biological mechanisms that underpin these adverse outcomes are not well understood. High-density lipoproteins (HDLs) are antiatherogenic by promoting the efflux of cholesterol from macrophages and by suppression of inflammation. Functional impairment of HDLs in obese and GDM-complicated pregnancies may have long-term effects on maternal and offspring health. In the present study, we assessed metrics of HDL function in sera of pregnant women with overweight/obesity of the DALI lifestyle trial (prepregnancy BMI ≥ 29 kg/m2) and women with normal weight (prepregnancy BMI < 25 kg/m2), as well as HDL functionalities in cord blood at delivery. We observed that pregravid obesity was associated with impaired serum antioxidative capacity and lecithin–cholesterol acyltransferase activity in both mothers and offspring, whereas maternal HDL cholesterol efflux capacity was increased. Interestingly, functionalities of maternal and fetal HDL correlated robustly. GDM did not significantly further alter the parameters of HDL function and metabolism in women with obesity, so obesity itself appears to have a major impact on HDL functionality in mothers and their offspring.

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“…The study results were also consistent with the literature on maternal cardiometabolic conditions affecting both cord blood profiles [ 34 ] and neurodevelopment. Overall findings were in line with research on low-grade, chronic inflammatory processes such as cardiometabolic health risk in the mother during pregnancy being linked with foetal development [ 35 ] and subsequent effects on outcomes such as IQ, socialisation, communication, expressive language, physical development, and executive function [ 8 , 9 , 36 , 37 ].…”

Section: Discussionsupporting

confidence: 92%

Maternal metabolic syndrome in pregnancy and child development at age 5: exploring mediating mechanisms using cord blood markers

Kwok

Speyer

Soursou

et al. 2023

BMC Med

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Background There is limited evidence on how the classification of maternal metabolic syndrome during pregnancy affects children’s developmental outcomes and the possible mediators of this association. This study uses a cohort sample of 12,644 to 13,832 mother–child pairs from the UK Born in Bradford Study to examine the associations between maternal metabolic syndrome classification (MetS) and child development outcomes at age 5, using cord blood markers as candidate mediators. Methods Maternal cardiometabolic markers included diabetes, obesity, triglycerides, high-density lipoprotein cholesterol, blood pressure, hypertension, and fasting glucose during pregnancy. Cord blood markers of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, leptin, and adiponectin were used as child mediators. Child outcomes included two starting school variables: British Picture Vocabulary Scale (BPVS) and the Letter Identification Assessment (LID), and five developmental milestone domains from a national UK framework: (1) communication and language (COM); (2) personal, social, and emotional (PSE); (3) physical development (PHY); (4) literacy (LIT); and (5) mathematics (MAT). Mediation models were used to examine the associations between the classification of maternal metabolic syndrome and child developmental milestones. Models were adjusted for potential maternal, socioeconomic, and child confounders such as maternal education, deprivation, and gestational age. Results In mediation models, significant total effects were found for MetS associations with children’s development in the LIT domain at age 5. MetS predicted individual cord blood mediators of lower HDL and increased leptin levels in both adjusted and unadjusted models. Total indirect effects (effects of all mediators combined) for MetS on a child’s COM and PSE domain were significant, through all child cord blood mediators of LDL, HDL, triglycerides, adiponectin, and leptin for adjusted models. Conclusions The results support the hypothesis that maternal metabolic syndrome classification during pregnancy is associated with some child developmental outcomes at age 5. After adjusting for maternal, child, and environmental covariates, maternal metabolic syndrome classification during pregnancy was associated with children’s LIT domain through direct effects of maternal metabolic health and indirect effects of cord blood markers (total effects), and COM and PSE domains via changes only in a child’s cord blood markers (total indirect effects).

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Maternal obesity influences the endocrine cord blood profile of their offspring

Cited by 6 publications

References 34 publications

In utero exposure to parabens and early childhood BMI z-scores – Associations between placental ethyl paraben, longitudinal BMI trajectories and cord blood metabolic biomarkers

In utero exposure to parabens and early childhood BMI z-scores – Associations between placental ethyl paraben, longitudinal BMI trajectories and cord blood metabolic biomarkers

Obesity Affects Maternal and Neonatal HDL Metabolism and Function

Maternal metabolic syndrome in pregnancy and child development at age 5: exploring mediating mechanisms using cord blood markers

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