Maternal diabetes as a teratogenic factor for congenital heart defects in infants of diabetic mothers

Abstract

Background Congenital heart defects (CHDs) are shown to have an association with maternal diabetes mellitus. The Bahraini population has a high prevalence of diabetes 16.3% thus putting it at increased risk of developing CHDs in infants of diabetic mothers (IDMs). Objective Describing the prevalence of CHDs in IDM in the Kingdom of Bahrain. Design A retrospective clinical study. Setting Bahrain Defense Force Hospital, Kingdom of Bahrain. Methods The study took place from January 1998 to January 2020. A history was recorded for all patients who were referred to the only tertiary cardiac center in Bahrain for echocardiography. Data was recorded on an Excel Sheet for analysis. A cardiac anatomy survey was conducted by an experienced pediatric cardiologist for each patient and the defects were categorized into acyanotic and cyanotic lesions. Results Five thousand five hundred sixty‐nine patients were referred for cardiac echocardiography. Three thousand two hundred fifty‐six patients were diagnosed with CHDs, 2,987 were non‐IDM whereas 269 were IDM. Patients diagnosed with non‐structural defects were excluded. Atrial septal defect (ASD) was identified in 744 patients and was more likely to occur in non‐IDM (p‐value = .005). Hypertrophic obstructive cardiomyopathy (HOCM) was identified in 35 patients and was more likely to occur in IDM (p‐value < .001). Transposition of the great arteries (TGAs) was identified in 80 patients and was more likely to occur in IDM (p‐value .002). Double inlet left ventricle (DILV), Hypoplastic Left Heart Syndrome (HPLHS), and Other Uni‐Ventricular Hearts were all more likely to occur in IDM with p‐values < .05. Conclusion This study showed significant association between fetal exposure to diabetes and the development of ASD, HOCM, TGA, DILV, HPLHS, and Other Uni‐Ventricular Hearts.

Exploration of Teratogenic Effects of Bambusa vulgaris on Wistar Rats by Evaluating Morphological and Skeletal Parameters

“…The various constituents present can exert diverse impacts on the developing fetus. [ 4 ] Following consumption, the chemical components inherent in the botanical commodity are assimilated into the circulatory system via the gastrointestinal tract. Subsequently, they can be disseminated to diverse tissues and organs, encompassing the placenta.…”

Toxic metals in pregnancy and congenital heart defects. Insights and new perspectives for a technology-driven reduction in food sources

“…The etiopathogenesis of CHD is complex and poorly understood, and only approximately 30% of cases can be attributable to chromosomal or single gene disorders, or other known causes (e.g., maternal diabetes, maternal viral infections) [8][9][10]. Conversely, in most cases, their cause is largely unknown and is suggested to be multifactorial, i.e., genetic, epigenetic, and environmental factors all influence and interact in the development of non-syndromal forms of CHD [11,12].…”