Maternal deprivation effect on morphine-induced CPP is related to changes in opioid receptors in selected rat brain regions (hippocampus, prefrontal cortex, and nucleus accumbens)

Askari, Nayere; Mousavi, Ali; Vaez-Mahdavi, Mohammad Reza

doi:10.1016/j.beproc.2022.104607

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“…Previous research has established that opioids affect various structures in the brain, including memory impairment with morphine [ 10 , 19 ]. However, the underlying mechanism of morphine-induced memory impairment is not fully elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, decreased antioxidant enzyme activity of enzymes like glutathione peroxidase (GPx) and superoxide dismutase (SOD) causes oxidative stress damage during morphine administration [ 8 ]. In vivo experiments in rats have established that oxidative stress results in neurodegeneration in multiple brain areas, including the hippocampus, nucleus accumbens, and cerebral cortex, related to morphine-induced apoptosis [ 7 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

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