Cross-talk between the HPA axis and addiction-related regions in stressful situations

Nikbakhtzadeh, Marjan; Ranjbar, Hoda; Moradbeygi, Khadijeh; Zahedi, Elham; Bayat, Mahnaz; Soti, Monavareh; Shabani, Mohammad

doi:10.1016/j.heliyon.2023.e15525

Cited by 5 publications

(4 citation statements)

References 156 publications

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“…This timing of the loss of retention within the therapeutic intervention is attributed to the withdrawal stage during the treatment process for SUD. HPA axis regulation is altered during substance abuse, so the individual endures heightened stress responsivity including heightened levels of cortisol, which can, in turn, heighten drug cravings [40]. Chronic heightened levels of cortisol can further result in the hindrance of memory retrieval and memory organization, which are utilized within the learning of sober-living habits.…”

Section: Mental Health and Equine Interactionmentioning

confidence: 99%

“…Development of skills indicates the ability to learn and, thus, cognitive function. Cognitive function within SUD patients, particularly memory development and organization, is hindered by HPA axis dysregulation, which is commonly observed with chronic substance abuse [29,40]. As such, the learning of skills can indicate improved function within the HPA axis for SUD patients.…”

Section: Human Physiological and Behavioral Responsesmentioning

confidence: 99%

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The Effects of a Collegiate Recovery Community Psychotherapy Program Incorporating Equine Interaction during the COVID-19 Pandemic on Young Adults with Substance Abuse Disorder

Holtcamp,

Nicodemus,

Phillips

et al. 2024

COVID

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While psychotherapy incorporating equine interaction (PIE) has proven to be a viable therapeutic intervention, it is not a common mental health service found on college campuses. Nevertheless, with the rise of mental health challenges on campuses after the COVID-19 pandemic, a need for effective therapeutic solutions is warranted. Therefore, the objective of this study was to determine the effect of a collegiate recovery community (CRC) PIE program for substance abuse disorder (SUD) compared to that of traditional cognitive behavioral therapy (CBT) and to determine whether physiological synchronization occurs between the human and horse during the therapy process. College-aged adults were recruited during the COVID-19 pandemic for two types of short-term SUD therapeutic interventions, CRC-PIE and CBT. Both groups completed a self-reporting survey assessing emotional safety. Vital signs measurements for human and horse participants within the CRC-PIE were collected prior to and after the first and last therapeutic sessions. Results concluded that although emotional safety did not improve significantly for PIE participants by the last therapy session (p = 0.85), emotional safety scores were significantly different between therapy types, with lower post-therapy scores for PIE (p = 0.04). As for physiological measures for PIE participants, respiratory rates (Human: p = 0.01; Horse: p = 0.01) and pain rating scores (Human: p = 0.03; Horse: p = 0.01) significantly decreased post-therapy and a strong positive correlation (R = 0.73, R2 = 0.53) associated with vital signs was observed between humans and horses. This human–horse physiological synchronization during the therapeutic intervention suggests that the horse may be a viable tool within campus CRC programs for the development of therapeutic alliances within the therapy process.

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Section: Mental Health and Equine Interactionmentioning

confidence: 99%

Section: Human Physiological and Behavioral Responsesmentioning

confidence: 99%

The Effects of a Collegiate Recovery Community Psychotherapy Program Incorporating Equine Interaction during the COVID-19 Pandemic on Young Adults with Substance Abuse Disorder

Holtcamp,

Nicodemus,

Phillips

et al. 2024

COVID

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“…IL-6 является одним из основных цитокинов, которые стимулируют ось HPA во время воспалительного стресса [18]. Также предполагается, что IL-6 играет роль в механизмах, связывающих психосоциальный стресс с повышенным риском таких заболеваний, как сердечнососудистые заболевания [19].…”

Section: результатыunclassified

Psychosocial risk factors for cardiovascular disease: vital exhaustion and its associations with biochemical markers of inflammation among persons 25-44 years old

Gafarov,

Gromova,

Kashtanova

et al. 2023

Russ J Cardiol

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Aim. To study the association of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and monocyte chemoattractant protein-1 (MCP-1) levels with vital exhaustion (VE) among men and women aged 25-44 years in Novosibirsk.Material and methods. At the Research Institute of Internal and Preventive Medicine (Novosibirsk), during 2013-2016, a cross-sectional survey of a random representative sample of people aged 25-44 years in one of the typical districts of Novosibirsk was carried out. A total of 975 individuals were examined (403 men, 530 women). The response rate was 71%. General examination and history collection were carried out according to standard methods included in the WHO program "MONICA-psychosocial (MOPSY)". All study participants completed the Maastricht Vital Exhaustion Questionnaire (MQ).Results. High and medium VE prevailed among women (15,7% and 40,6%) than among men (5,5% and 32,8%) (p<0,001). Median serum levels of IL-6 were high VE among both sexes 1,41 [0,70;4,60] pg/ml, compared with medium VE 1,20 [0,65;2,90] pg/ml, and low VE 1,12 [0,58;2,32] pg/ml (p<0,01), and among women with high VE 1,53 [0,72;4,33] pg/ml, compared with medium VE 1,14 [0,63;2,36] pg/ml and low VE 0,95 [0,50;1,98] pg/ml (p<0,05). Serum TNF-α was higher among women with high VE (6,01±3,23 pg/ml) than with medium VE (5,63±4,16 pg/ml) and low VE (4,95±2,85 pg/ml) (p=0,025). Mean serum MCP-1 levels among both sexes, men and women, were higher with high VE (324,55±161,89 pg/ml, 270,75±107,92 pg/ml and 338,81±171,1 pg/ml) than with medium (251,78±123,4 pg/ml, 262,46±134,9 pg/ml and 245,22±115,61 pg/ml), and low VE (227,59±101,03 pg/ml, 234,51±104,53 pg/ml and 220,17±96,81 pg/ml) (p<0,001).Conclusion. An increase in the average levels of inflammation biochemical markers (IL-6, TNF-α, MCP-1) was established in individuals 25-44 years old with a high VE.

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“…Motivation-focused models also posit, that the frontal cortex, responsible for executive functioning, occupies an important place in the process of shaping and controlling addictive behaviors, with the ventral striatum and ventromedial cortex being related to reward processing and risk/benefit decision-making and selection of immediate short-term rewards, while the dorsal prefrontal cortical brain regions are related to delayed and longterm choices and motivations as indicated by Marusich et al (2019). Furthermore, from a developmental perspective, prefrontal cortical brain regions are the last to mature, and, likely, adolescents' vulnerability to psychoactive substance use and abuse or other mental health disorders is linked to such late development (Nikbakhtzadeh et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Resilience and coping strategies in a sample of consumers and non-consumers of psychoactive substances

Klimenko,

Hernández-Flórez,

Gómez-Galindo

et al. 2023

Rev. estudios psicol.

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A quantitative, non-experimental correlational study, with a cross-sectional design, aimed at describing coping strategies and resilience in two groups of young consumers and non-consumers of psychoactive substances. The Coping Strategies Inventory, designed by Tobin et al. (1989) and the Resilience Scale SV-RES by Saavedra and Villalta (2008) were used. The results suggest that the combination of low social support strategies, social isolation, and high levels of emotional expression may seem to be associated with substance use as a possible escape route for coping with stressful situations. In terms of resilience, the results are consistent with other studies that show lower levels of resilience in the population of psychoactive substance users. Finally, this research leads to the conclusion that resilience and adequate coping strategies are protective factors that should be strengthened in the child and adolescent population in order to prevent substance use behavior as an escape route from problems.

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Cross-talk between the HPA axis and addiction-related regions in stressful situations

Cited by 5 publications

References 156 publications

The Effects of a Collegiate Recovery Community Psychotherapy Program Incorporating Equine Interaction during the COVID-19 Pandemic on Young Adults with Substance Abuse Disorder

The Effects of a Collegiate Recovery Community Psychotherapy Program Incorporating Equine Interaction during the COVID-19 Pandemic on Young Adults with Substance Abuse Disorder

Psychosocial risk factors for cardiovascular disease: vital exhaustion and its associations with biochemical markers of inflammation among persons 25-44 years old

Resilience and coping strategies in a sample of consumers and non-consumers of psychoactive substances

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