Maternal consumption of piceatannol: A nutritional neuroprotective strategy against hypoxia-ischemia in rat neonates

Dumont, Ursule; Sanchez, Sandrine; Olivier, Benjamin; Chateil, Jean‐François; Pellerin, Luc; Beauvieux, Marie-Christine; Bouzier‐Sore, Anne‐Karine; Roumes, Hélène

doi:10.1016/j.brainres.2019.04.012

Cited by 16 publications

(24 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent studies showed the piceatannol superiority over the resveratrol as antioxidant and cytoprotector [16] due to its higher capacity of chelators/sequestrants reactive oxygen species (ROS) [17]. Maternal supplementation with piceatannol is neuroprotective in rat neonatal hypoxia-ischemia [18]. Piceatannol affects peripheral clock gene expression and may prevent circadian disturbance [19].…”

Section: Introductionmentioning

confidence: 99%

Piceatannol Increases Antioxidant Defense and Reduces Cell Death in Human Periodontal Ligament Fibroblast under Oxidative Stress

et al. 2019

View full text Add to dashboard Cite

Piceatannol is a resveratrol metabolite that is considered a potent antioxidant and cytoprotector because of its high capacity to chelate/sequester reactive oxygen species. In pathogenesis of periodontal diseases, the imbalance of reactive oxygen species is closely related to the disorder in the cells and may cause changes in cellular metabolism and mitochondrial activity, which is implicated in oxidative stress status or even in cell death. In this way, this study aimed to evaluate piceatannol as cytoprotector in culture of human periodontal ligament fibroblasts through in vitro analyses of cell viability and oxidative stress parameters after oxidative stress induced as an injury simulator. Fibroblasts were seeded and divided into the following study groups: control, vehicle, control piceatannol, H2O2 exposure, and H2O2 exposure combined with the maintenance in piceatannol ranging from 0.1 to 20 μM. The parameters analyzed following exposure were cell viability by trypan blue exclusion test, general metabolism status by the 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) method, mitochondrial activity through the ATP production, total antioxidant capacity, and reduced gluthatione. Piceatannol was shown to be cytoprotective due the maintenance of cell viability between 1 and 10 μM even in the presence of H2O2. In a concentration of 0.1 μM piceatannol decreased significantly cell viability but increased cellular metabolism and antioxidant capacity of the fibroblasts. On the other hand, the fibroblasts treated with piceatannol at 1 μM presented low metabolism and antioxidant capacity. However, piceatannol did not protect cells from mitochondrial damage as measured by ATP production. In summary, piceatannol is a potent antioxidant in low concentrations with cytoprotective capacity, but it does not prevent all damage caused by hydrogen peroxide.

show abstract

Section: Introductionmentioning

confidence: 99%

Piceatannol Increases Antioxidant Defense and Reduces Cell Death in Human Periodontal Ligament Fibroblast under Oxidative Stress

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Cerebral HI was performed as described previously 16,25,65 . Briefly, P7-pups of either sex, weighing 14-20 g, were anaesthetized with isoflurane (induction: 4%; maintenance: 1.5%) and a midline neck incision was made under local anesthesia (lidocaine 0.5%).…”

Section: Model Of Hypoxic-ischemic Brain Injurymentioning

confidence: 99%

“…Hippocampal-dependent long-term memory of pups was assessed using the novel object recognition test, as described previously 25 . Briefly, after an habituation period (10 min) in the open field (50 cm x 50 cm) on day 1, pups were further allowed to freely explore two identical objects placed in opposite corners of the arena for 10 min during the following two days.…”

Section: Novel Object Recognition (P45) 31mentioning

confidence: 99%

“…Its hydroxylated analogue, trans-piceatannol (PIC), found in large quantities in the seeds of passion fruit, has a two-fold higher bioavailability 24 . However, very few studies have been carried out with this compound and only one study has been conducted on neonatal HI 25 . In this study, we show that PIC maternal supplementation (0.15 mg/kg/d) is neuroprotective by decreasing the incidence of HI lesion, decreasing the lesion volume and counteracting the deleterious effects on sensorimotor and cognitive abilities of pups.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Maternal alcoholism and neonatal hypoxia-ischemia: Neuroprotection by stilbenoid polyphenols

et al. 2020

Self Cite

View full text Add to dashboard Cite

The impact of maternal nutrition on neurodevelopment and neonatal neuroprotection is a research topic with increasing interest. Maternal diet can also have deleterious effects on fetal brain development. Fetal exposure to alcohol is responsible for poor neonatal global development, and may increase brain vulnerability to hypoxic-ischemic (HI) encephalopathy, one of the major causes of acute mortality and chronic neurological disability in newborns. Despite frequent prevention campaigns, about a quarter of women in the general population drinks alcohol during pregnancy and breastfeeding. This study was inspired by this alarming fact. Its aim was to evaluate the beneficial effects of maternal supplementation with two polyphenols during pregnancy and breastfeeding, on hypoxic-ischemic (HI) neonate rat brain damages, sensorimotor and cognitive impairments, in a context of moderate maternal alcoholism. Both stilbenoid polyphenols, transresveratrol (RSV -0.15 mg/kg/day), and its hydroxylated analog, trans-piceatannol (PIC -0.15 mg/kg/day), were administered in the drinking water, containing or not alcohol (0.5 g/kg/day). In a 7-day post-natal rat model of HI, our data showed that moderate maternal alcoholism does not increase brain lesion sizes measured by MRI but leads to higher motor impairments. RSV supplementation could not reverse the deleterious effects of HI coupled with maternal alcoholism. However, PIC supplementation led to a recovery of all sensorimotor and cognitive functions. This neuroprotection was obtained with a dose of PIC corresponding to the consumption of a single passion fruit per day for a pregnant woman. Highlights:• Maternal alcoholism increases deficits induced by neonatal hypoxia-ischemia (HI).• These impairments are counteracted by maternal supplementation with piceatannol.• Doses used are equivalent to the piceatannol content of a single passion fruit.• Piceatannol is neuroprotective in neonatal HI in a context of maternal alcoholism.• Originality of the study: nutritional and transgenerational therapeutic approach.

show abstract

“…Piceatannol, a bioactive stilbene derivative from medicinal plants Passiflora edulis or Gnetum parvifolium, restores 4-HNE-induced PARP cleavage and apoptosis regulator Bcl-2 expression, and down-regulates the phosphorylation of JNK (p-JNK) in PC12 cell death and nuclear condensation [25]. Recently, maternal supplementation with piceatannol has been demonstrated to have neuroprotection against neonate brain damage and reverse the sensorimotor deficit and cognitive impairment in rats [26]. Additionally, as a traditional medicinal plant in China and Korea, citri reticulatae viride pericarpium also restores 4-HNE-induced inflammatory injury in PC12 cells via inhibiting the activation of p-JNK and nuclear factor kappa-B (NF-κB) [27].…”

Section: Neuroprotectionmentioning

confidence: 99%

Can Medicinal Plants and Bioactive Compounds Combat Lipid Peroxidation Product 4-HNE-Induced Deleterious Effects?

Wang

et al. 2020

Biomolecules

View full text Add to dashboard Cite

The toxic reactive aldehyde 4-hydroxynonenal (4-HNE) belongs to the advanced lipid peroxidation end products. Accumulation of 4-HNE and formation of 4-HNE adducts induced by redox imbalance participate in several cytotoxic processes, which contribute to the pathogenesis and progression of oxidative stress-related human disorders. Medicinal plants and bioactive natural compounds are suggested to be attractive sources of potential agents to mitigate oxidative stress, but little is known about the therapeutic potentials especially on combating 4-HNE-induced deleterious effects. Of note, some investigations clarify the attenuation of medicinal plants and bioactive compounds on 4-HNE-induced disturbances, but strong evidence is needed that these plants and compounds serve as potent agents in the prevention and treatment of disorders driven by 4-HNE. Therefore, this review highlights the pharmacological basis of these medicinal plants and bioactive compounds to combat 4-HNE-induced deleterious effects in oxidative stress-related disorders, such as neurotoxicity and neurological disorder, eye damage, cardiovascular injury, liver injury, and energy metabolism disorder. In addition, this review briefly discusses with special attention to the strategies for developing potential therapies by future applications of these medicinal plants and bioactive compounds, which will help biological and pharmacological scientists to explore the new vistas of medicinal plants in combating 4-HNE-induced deleterious effects.

show abstract

Maternal consumption of piceatannol: A nutritional neuroprotective strategy against hypoxia-ischemia in rat neonates

Cited by 16 publications

References 33 publications

Piceatannol Increases Antioxidant Defense and Reduces Cell Death in Human Periodontal Ligament Fibroblast under Oxidative Stress

Piceatannol Increases Antioxidant Defense and Reduces Cell Death in Human Periodontal Ligament Fibroblast under Oxidative Stress

Maternal alcoholism and neonatal hypoxia-ischemia: Neuroprotection by stilbenoid polyphenols

Can Medicinal Plants and Bioactive Compounds Combat Lipid Peroxidation Product 4-HNE-Induced Deleterious Effects?

Contact Info

Product

Resources

About