Can Medicinal Plants and Bioactive Compounds Combat Lipid Peroxidation Product 4-HNE-Induced Deleterious Effects?

Abstract

The toxic reactive aldehyde 4-hydroxynonenal (4-HNE) belongs to the advanced lipid peroxidation end products. Accumulation of 4-HNE and formation of 4-HNE adducts induced by redox imbalance participate in several cytotoxic processes, which contribute to the pathogenesis and progression of oxidative stress-related human disorders. Medicinal plants and bioactive natural compounds are suggested to be attractive sources of potential agents to mitigate oxidative stress, but little is known about the therapeutic potentials especially on combating 4-HNE-induced deleterious effects. Of note, some investigations clarify the attenuation of medicinal plants and bioactive compounds on 4-HNE-induced disturbances, but strong evidence is needed that these plants and compounds serve as potent agents in the prevention and treatment of disorders driven by 4-HNE. Therefore, this review highlights the pharmacological basis of these medicinal plants and bioactive compounds to combat 4-HNE-induced deleterious effects in oxidative stress-related disorders, such as neurotoxicity and neurological disorder, eye damage, cardiovascular injury, liver injury, and energy metabolism disorder. In addition, this review briefly discusses with special attention to the strategies for developing potential therapies by future applications of these medicinal plants and bioactive compounds, which will help biological and pharmacological scientists to explore the new vistas of medicinal plants in combating 4-HNE-induced deleterious effects.

Ferroptosis in Chronic Liver Diseases: Opportunities and Challenges

“…PUFAs produce large amounts of MDA through chemical and enzymatic reactions (Tsikas, 2017) and are the most commonly measured biomarkers of lipid peroxidation. Moreover, the accumulation of 4-HNE and the formation of 4-HNE adducts caused by redox imbalance also aggravate the cytotoxic effect (Wang F. X. et al, 2020), which, in turn, increases the permeability of the cell membrane and causes ferroptosis.…”

Phytochemical Omics in Medicinal Plants

“…Oxidative stress is one of the main processes in human disorders. Wang et al contributed a review on bioactive compounds for treating oxidative stress-related human disorders involving the toxic reactive aldehyde 4-hydroxynonenal (4-HNE), an advanced lipid peroxidation end product [ 3 ]. A number of related disorders are listed, such as cardiovascular injury, eye damage, liver injury, neurotoxicity, neurological disorder and energy metabolism disorder in order to discuss their prevention and treatment by bioactive compounds from particular medicinal plants, and finally, possible strategies for future research and applications combating deleterious effects induced by 4-HNE are proposed.…”