Maternal and fetal outcome in subclinical hypothyroidism in Jammu region, North India

Singh, Gagan D.; Kaul, Indu; Singh, Anuradha; Meinia, Sushant Kumar

doi:10.18203/2320-1770.ijrcog20162128

Cited by 4 publications

(5 citation statements)

References 18 publications

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“…In our study maternal complications like pre-eclampsia, placental abruption, post-partum haemorrhage were found in 9.09%, 4.55% and 4.55% respectively and fetal complication like low birth weight was found in (23) 13.3% which were lower than that found by Davis in which maternal complications were common and included preeclampsia (44%), placental abruption (19%), postpartum hemorrhage (19%) and fetal complication low birth weight was found in 31%. Low birth weight found in our study (13.3%) found to be comparable with the study (24) conducted by Singh G et al in which 18.86% women delivered low (25) birth weight babies. Aditya et al also reported that both subclinical and overt hypothyroidism were associated with signicantly increased low birth weight rates.…”

Section: Prevelance Of Hypothyroidism Percentagesupporting

confidence: 91%

“…In our study placental abruption was found in 4.55% of hypothyroid (22) patients while Casey et al reported that pregnancies in women with subclinical hypothyroidism were three times more likely to be complicated by placental abruption and it was statistically signicant (p=0.026).PROM found in our study was higher (9.09%) than that (24) found in study conducted by Singh G. et al in which PPROM was found in 5.71% of hypothyroid patients.In present study gestational diabetes was found more in hypothyroid (9.09%) compared to (26) euthyroid patients (2.02%). Sahu et al also found gestational diabetes signicantly more in overt hypothyroidism group (P=0.04).…”

Section: Prevelance Of Hypothyroidism Percentagecontrasting

confidence: 52%

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Detection of Hypothyroidism in Early Pregnancy: Universal Screening

Kour

Kour²

2020

IJAR

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Background: Thyroid dysfunction is one of the most common endocrine disorders in women of childbearing (1), second only to diabetes mellitus.The aim of this systemic review was to determine whether an increased maternal TSH level and normal serum T4 levels, as seen in SCH, could also be associated with pregnancy complications. Methods: This study was conducted in Nobel hospital,Pune January 2015 to July 2016 in all the pregnant women attending antenatal clinic in their first trimester of pregnancy. Data was collected on a pre-designed, pre-tested study proforma which includes socio-demographic information of patients, detailed clinical history and examinations of pregnant women and babies. Blood samples were taken under all aseptic precautions and were sent to laboratory of the institute for routine investigations and thyroid profile. Patients were followed up till delivery and babies were followed up till discharge from the hospital. Results:This study was conducted in 220 patients in obstetrics and gynaecology department in Noble Hospital, Pune. Out of 220 cases,198 cases were euthyroid, 13 cases were subclinical hypothyroid and 9 cases were overt hypothyroid. Hypothyroidism was found in 22(10%) of pregnant women in their first trimester. Out of which, 13(5.91%) had subclinical hypothyroidism and 9(4.09%) had overt hypothyroidism. Majority of the patients 45.45% were in age group of 26-30years. 90.91% of hypothyroid patients had regular cycles and 9.09% had irregular cycles. Hypothyroidism was equally distributed between primi and multigravida patients. 31.82% of hypothyroid patients had previous history of abortions and 68.18% had no such history.18.18% of hypothyroid patients had history of infertility and 31.82% had no history of infertility. Anti-TPO was present in 9.09% and none of euthyroid patients. Maternal and Fetal complications were found more in hypothyroid patients than euthyroid patients. Conclusion: Most of the patients in our study who have subclinical thyroid disease are asymptomatic, so screening is the most convenient method to identify such patients. Follow-up of abnormal TSH values with FT3 and FT4 may yield valuable results which could enable us for therapeutic intervention and may go a long way in preventing adverse pregnancy outcomes.

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Section: Prevelance Of Hypothyroidism Percentagesupporting

confidence: 91%

Section: Prevelance Of Hypothyroidism Percentagecontrasting

confidence: 52%

Detection of Hypothyroidism in Early Pregnancy: Universal Screening

Kour

Kour²

2020

IJAR

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“…6 Preeclampsia, eclampsia and pregnancy induced hypertension have significantly higher incidence in SCH (15%) in comparison with the incidence in general population (7.6%). 6 Risk of developing gestational diabetes increases with increase of thyrotropin (TSH) level. 7 The complications of pregnancies did not depend on whether the hypothyroidism was overt or subclinical but mainly on the treatment received.…”

Section: Introductionmentioning

confidence: 94%

“…Maternal hypothyroidism has been associated with adverse obstetrical outcome, such as spontaneous abortion, gestational hypertension, premature delivery. 6 There is threefold increase risk of placental abruption and two-fold increase risk of preterm delivery (before 34 weeks of gestation) noted in both overt and subclinical hypothyroidism. 6 Preeclampsia, eclampsia and pregnancy induced hypertension have significantly higher incidence in SCH (15%) in comparison with the incidence in general population (7.6%).…”

Section: Introductionmentioning

confidence: 99%

“…6 There is threefold increase risk of placental abruption and two-fold increase risk of preterm delivery (before 34 weeks of gestation) noted in both overt and subclinical hypothyroidism. 6 Preeclampsia, eclampsia and pregnancy induced hypertension have significantly higher incidence in SCH (15%) in comparison with the incidence in general population (7.6%). 6 Risk of developing gestational diabetes increases with increase of thyrotropin (TSH) level.…”

Section: Introductionmentioning

confidence: 99%

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Pregnancy outcome in anti-thyroid peroxidase antibody negative subclinical hypothyroid women with and without treatment

Roy¹,

Saha

Datta

2022

Int J Reprod Contracept Obstet Gynecol

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Background: There is insufficient evidence in the literature whether pregnancy with anti-thyroid peroxidase antibody negative subclinical hypothyroidism is benefited with treatment.Methods: The 100 uncomplicated primigravida women before 16 weeks of gestation who were anti thyroid peroxidase antibody negative and diagnosed as subclinical hypothyroid based on serum thyroid stimulating hormone (TSH), Free T4 (FT4) and anti-thyroid peroxidase antibody (anti TPO Ab) were enrolled in this study. They were divided into case and control group having 50 patients in each arm. Case group were treated with levothyroxine therapy as per the recommended dose. Maternal and perinatal outcome were compared between the two groups.Results: In our study we had found increased percentage of cases of antepartum hemorrhage (APH), pregnancy induced hypertension (PIH), pre-labour rupture of membrane (PROM), preterm delivery, meconium-stained liquor, intrauterine growth restriction (IUGR), low birth weight (LBW), APGAR score at 1 and 5 minutes, neonatal hyperbilirubinemia and NICU admission among women who were not treated but it was not statistically significant when compared with control group.Conclusions: When compared between the treated and non-treated group in anti TPO Ab negative subclinical hypothyroid patients, we didn’t find any significant difference in parameters studied by us. In view of inadequate literature, controversy exists whether to treat or not anti TPO negative subclinical hypothyroidism in pregnancy with levothyroxine.

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