Maternal and Fetal Carbohydrate, Lipid and Protein Metabolisms

Şengül, Özlem; Dede, Suat

doi:10.15197/sabad.1.11.93

Cited by 5 publications

(7 citation statements)

References 54 publications

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“…1,4,8 The full-term foetus is capable of responding to the stress and to a decrease of umbilical and/or placental flow by activating metabolic pathways that provide energy supply in a catabolic state. 5 Our results suggest that both glycogenic and ketogenic amino acids are increased at birth in neonates born vaginally compared to elective caesarean section where alanine showed the most increase. Alanine has a vital role in gluconeogenesis 4 even though, in most cases, it is not fully initiated at birth.…”

Section: Discussionmentioning

confidence: 55%

“…1,3,4 Glucose is the primary energy substrate for the foetus, leaving proteins and fatty acids to be used for growth and development. 2,5 Gluconeogenesis and ketogenesis are not active in utero, but can be activated in extreme cases, such as severe maternal starvation. 3,6 Initiation of birth involves co-operating maternal, placental and foetal factors.…”

Section: Introductionmentioning

confidence: 99%

“…That state continues until the nutrition for the neonate is established by lactogenesis and the adaptation of the gastrointestinal tract for handling volume and sources of nutrition needed is sufficient 1,3,4 . Glucose is the primary energy substrate for the foetus, leaving proteins and fatty acids to be used for growth and development 2,5 . Gluconeogenesis and ketogenesis are not active in utero, but can be activated in extreme cases, such as severe maternal starvation 3,6 …”

Section: Introductionmentioning

confidence: 99%

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Mode of delivery was associated with transient changes in the metabolomic profile of neonates

et al. 2021

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Mode of delivery was associated with transient changes in the metabolomic profile of neonates

et al. 2021

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“…Nutritional factors also need to get more attention; review conducted by Singletary et al (27) suggested that dietary factors can influence some cellular processes including autophagy. Change of nutrition and metabolism in pregnancy can also contribute on preeclampsia and related processes (29). Various components of foods, including vitamin D, selenium, curcumin, resveratrol and genistein can stimulate vacuolization in autophagy process.…”

Section: Discussionmentioning

confidence: 99%

Comparison of LC3 and Caspase 3 level in normal pregnancy, early onset preeclampsia, and late onset preeclampsia

2018

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Background: Preeclampsia is still become main cause of maternal and perinatal morbidity and mortality in addition to bleeding and infection. Preeclampsia is a pregnancy complication that occurs in about 5-10% and become main cause of maternal and fetal mortality and morbidity. The etiology and pathogenesis of preeclampsia syndrome have not fully understood. Autophagy and apoptosis is thought to play a role in the pathogenesis of preeclampsia. This research was done to see the difference in the expression of LC3 and Caspase 3 in normal pregnancy, early onset preeclampsia (EOP) and late onset preeclampsia (LOP) groups. Methods: This was a cross sectional study, research was conducted in February until May 2014. Immunohistochemical examination of the placenta was done to assess the expression of LC3 and caspase 3. Results: Expression of LC3 in EOP was higher than LOP and normal pregnancies expression of Caspase 3 in EOP was higher than LOP and normal pregnancy expression of Caspase 3 in EOP was higher than normal pregnancy. Conclusions: There was no difference between expression of LC3 in normal pregnancy, EOP and LOP but there was a difference between expression of Caspase 3 in normal pregnancy, EOP and LOP. There was a difference between expression of Caspase 3 in normal pregnancy and LOP.

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“…estational weight gain (GWG) reflects numerous endocrine and metabolic changes that occur in the maternal body during physiological adaptation to pregnancy, fetal energy supply and preparation for lactation [1]. Pathological weight gain is considered to be a significant and independent risk factor for obstetric and perinatal complications such as preeclampsia, gestational diabetes, and macrosomia, and increases operative delivery and the development of overweight and obesity after delivery [2].…”

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confidence: 99%

The role of resistin in the genesis of metabolic disorders in pathological pregnancy

Ostafiichuk¹

2019

Ukr.Biochem.J.

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Pathological gestational weight gain (GWG) is a risk factor for obstetric and perinatal complications. High metabolic activity of adipose tissue and the placenta during pregnancy manifests as an increased production of adipokines that are involved in glucose regulation and insulin sensitivity. The aim of this study was to determine the role of resistin in the genesis of metabolic disorders in pathological GWG pregnancies. The 163 pregnant women were examined in the study: 97 (59.5%) had normal, 18 (11.0%) had insufficient and 48 (29.4%) had excessive prepregnancy weight and obesity. GWG was the recommended level in 56 (34.4%), insufficient in 33 (20.2%), and excessive in 74 (45.4%) women. Anthropometry was performed in each trimester of pregnancy, the weight gain was measured, and the percentage of body fat mass, concentrations of resistin, glucose, insulin, and the HOMA-IR were evaluated. Positive associations were found between hyperresistinemia in the second trimester of pregnancy, and subsequent weight gain (r = 0.27, P = 0.0006), percentage of body fat mass (r = 0.93, P = 0.000) and insulin resistance (r = 0.89, P = 0.000) in late pregnancy; these associations were especially evident in excessive GWG. Determination of predictors of insulin resistance, associated with endocrine activity of adipose tissue, such as the adipokine resistin, in the second trimester of pregnancy may help to predict the severity of metabolic shifts during pregnancy and the risk of developing obstetric and perinatal complications.

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Maternal and Fetal Carbohydrate, Lipid and Protein Metabolisms

Abstract: ABSTRACT

Cited by 5 publications

References 54 publications

Mode of delivery was associated with transient changes in the metabolomic profile of neonates

Mode of delivery was associated with transient changes in the metabolomic profile of neonates

Comparison of LC3 and Caspase 3 level in normal pregnancy, early onset preeclampsia, and late onset preeclampsia

The role of resistin in the genesis of metabolic disorders in pathological pregnancy

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