Mode of delivery was associated with transient changes in the metabolomic profile of neonates

Vidarsdottir, Harpa; Halldórsson, Thorhallur I.; Geirsson, Reynir Tómas; Bjarnason, Ragnar; Franzson, Leifur; Valdimarsdóttir, Unnur; Þórkelsson, Þórður

doi:10.1111/apa.15822

Cited by 3 publications

(4 citation statements)

References 31 publications

(92 reference statements)

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“… 2 , 4 , 6 , 19 Previously, delivery mode and diet have been shown to induce clear separation in fecal metabolic profiling after birth. 20–22 Consistently, L-carnitine and short-chain acylcarnitines were elevated in C-section or formula-fed newborns compared with the vaginally delivered or breast-fed newborns (Figure S3a-c). However, the differences in distinct fecal aylcarnitines being identified based on delivery mode and diet in early age, were lost when the infants reached 12 months of age (data not shown).…”

Section: Resultsmentioning

confidence: 57%

“…Medium- and long-chain acylcarnitines (C10:0, C12:1, and C14:1) were increased at newborn age and remained high even at 4 months only in the vaginally born infants ( Figure 4a , and Table S4-1), suggesting the potential influence of delivery mode on fatty acid oxidation. 20 The accumulation of dicarboxylic fatty acids in the urine of C-section infants also supported the occurring of alternative fatty acid oxidation mechanisms. 24 Vaginally delivered infants have different microbiota composition and functionality from C-section 25 and therefore is expected to have different contribution to the gut metabolome.…”

Section: Resultsmentioning

confidence: 87%

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Maturation of the gut metabolome during the first year of life in humans

Ouyang,

Ding,

Huang

et al. 2023

Gut Microbes

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The gut microbiota is involved in the production of numerous metabolites that maintain host wellbeing. The assembly of the gut microbiome is highly dynamic, and influenced by many postnatal factors, moreover, little is known about the development of the gut metabolome. We showed that geography has an important influence on the microbiome dynamics in the first year of life based on two independent cohorts from China and Sweden. Major compositional differences since birth were the high relative abundance of Bacteroides in the Swedish cohort and Streptococcus in the Chinese cohort. We analyzed the development of the fecal metabolome in the first year of life in the Chinese cohort. Lipid metabolism, especially acylcarnitines and bile acids, was the most abundant metabolic pathway in the newborn gut. Delivery mode and feeding induced particular differences in the gut metabolome since birth. In contrast to C-section newborns, medium- and long-chain acylcarnitines were abundant at newborn age only in vaginally delivered infants, associated by the presence of bacteria such as Bacteroides vulgatus and Parabacteroides merdae . Our data provide a basis for understanding the maturation of the fecal metabolome and the metabolic role of gut microbiota in infancy.

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Section: Resultsmentioning

confidence: 57%

Section: Resultsmentioning

confidence: 87%

Maturation of the gut metabolome during the first year of life in humans

Ouyang,

Ding,

Huang

et al. 2023

Gut Microbes

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“…One found that low birth weight and extremely macrosomic newborns showed dissimilar metabolomic profiles when compared to appropriate-for-gestational age neonates [ 837 ]. The other estimated potential differences in neonatal metabolomic profiles at birth and at the time of NBS by delivery mode and found small differences, if any, and concluded that the mode of delivery does not affect the results of NBS [ 838 ].…”

Section: Resultsmentioning

confidence: 99%

Current Status of Newborn Bloodspot Screening Worldwide 2024: A Comprehensive Review of Recent Activities (2020–2023)

Therrell,

Padilla,

Borrajo

et al. 2024

IJNS

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Newborn bloodspot screening (NBS) began in the early 1960s based on the work of Dr. Robert “Bob” Guthrie in Buffalo, NY, USA. His development of a screening test for phenylketonuria on blood absorbed onto a special filter paper and transported to a remote testing laboratory began it all. Expansion of NBS to large numbers of asymptomatic congenital conditions flourishes in many settings while it has not yet been realized in others. The need for NBS as an efficient and effective public health prevention strategy that contributes to lowered morbidity and mortality wherever it is sustained is well known in the medical field but not necessarily by political policy makers. Acknowledging the value of national NBS reports published in 2007, the authors collaborated to create a worldwide NBS update in 2015. In a continuing attempt to review the progress of NBS globally, and to move towards a more harmonized and equitable screening system, we have updated our 2015 report with information available at the beginning of 2024. Reports on sub-Saharan Africa and the Caribbean, missing in 2015, have been included. Tables popular in the previous report have been updated with an eye towards harmonized comparisons. To emphasize areas needing attention globally, we have used regional tables containing similar listings of conditions screened, numbers of screening laboratories, and time at which specimen collection is recommended. Discussions are limited to bloodspot screening.

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“…The lack of mediation effects on childhood overweight, for the metabolites mediating the effect of gestational age on rapid growth, paves the way to different interpretations. First, cord blood metabolite concentrations were found to be transient by delivery mode [ 40 ], which could have contributed to a lack of link with childhood overweight. Second, because these cord blood metabolites mediated the effect of gestational age on rapid growth, which was inherent to their selection and rapid growth is a phenotype closer to birth, the studied metabolites may have a role in the origin of metabolic programming that we were not able to capture yet in relation to overweight later in childhood [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight

et al. 2022

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Background The mechanisms underlying childhood overweight and obesity are poorly known. Here, we investigated the direct and indirect effects of different prenatal exposures on offspring rapid postnatal growth and overweight in childhood, mediated through cord blood metabolites. Additionally, rapid postnatal growth was considered a potential mediator on childhood overweight, alone and sequentially to each metabolite. Methods Within four European birth-cohorts (N = 375 mother-child dyads), information on seven prenatal exposures (maternal education, pre-pregnancy BMI, weight gain and tobacco smoke during pregnancy, age at delivery, parity, and child gestational age), selected as obesogenic according to a-priori knowledge, was collected. Cord blood levels of 31 metabolites, associated with rapid postnatal growth and/or childhood overweight in a previous study, were measured via liquid-chromatography-quadrupole-time-of-flight-mass-spectrometry. Rapid growth at 12 months and childhood overweight (including obesity) between four and eight years were defined with reference to WHO growth charts. Single mediation analysis was performed using the imputation approach and multiple mediation analysis using the extended-imputation approach. Results Single mediation suggested that the effect of maternal education, pregnancy weight gain, parity, and gestational age on rapid postnatal growth but not on childhood overweight was partly mediated by seven metabolites, including cholestenone, decenoylcarnitine(C10:1), phosphatidylcholine(C34:3), progesterone and three unidentified metabolites; and the effect of gestational age on childhood overweight was mainly mediated by rapid postnatal growth. Multiple mediation suggested that the effect of gestational age on childhood overweight was mainly mediated by rapid postnatal growth and that the mediating role of the metabolites was marginal. Conclusion Our findings provide evidence of the involvement of in utero metabolism in the propensity to rapid postnatal growth and of rapid postnatal growth in the propensity to childhood overweight. We did not find evidence supporting a mediating role of the studied metabolites alone between the studied prenatal exposures and the propensity to childhood overweight.

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Mode of delivery was associated with transient changes in the metabolomic profile of neonates

Abstract: Aims: To estimate potential differences in neonatal metabolomic profiles at birth and at the time of newborn screening by delivery mode.

Cited by 3 publications

References 31 publications

Maturation of the gut metabolome during the first year of life in humans

Maturation of the gut metabolome during the first year of life in humans

Current Status of Newborn Bloodspot Screening Worldwide 2024: A Comprehensive Review of Recent Activities (2020–2023)

Cord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight

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