Comparison of LC3 and Caspase 3 level in normal pregnancy, early onset preeclampsia, and late onset preeclampsia

Abstract

Background: Preeclampsia is still become main cause of maternal and perinatal morbidity and mortality in addition to bleeding and infection. Preeclampsia is a pregnancy complication that occurs in about 5-10% and become main cause of maternal and fetal mortality and morbidity. The etiology and pathogenesis of preeclampsia syndrome have not fully understood. Autophagy and apoptosis is thought to play a role in the pathogenesis of preeclampsia. This research was done to see the difference in the expression of LC3 and Caspase 3 in normal pregnancy, early onset preeclampsia (EOP) and late onset preeclampsia (LOP) groups. Methods: This was a cross sectional study, research was conducted in February until May 2014. Immunohistochemical examination of the placenta was done to assess the expression of LC3 and caspase 3. Results: Expression of LC3 in EOP was higher than LOP and normal pregnancies expression of Caspase 3 in EOP was higher than LOP and normal pregnancy expression of Caspase 3 in EOP was higher than normal pregnancy. Conclusions: There was no difference between expression of LC3 in normal pregnancy, EOP and LOP but there was a difference between expression of Caspase 3 in normal pregnancy, EOP and LOP. There was a difference between expression of Caspase 3 in normal pregnancy and LOP.