Maternal Age Distribution of Down-Syndrome at Pediatric Growth and Development Clinic, 2015-2019

Abstract

Introduction: Down Syndrome is a common chromosome abnormality among infants. This condition is Present in 1 over 800 deliveries. Advanced maternal age is a risk factor for Down syndrome. Other miscellaneous factors are radiation, infection, autoimmune and paternal age. The Aim is to determine maternal age distribution of Down syndrome at pediatric growth and development polyclinic, Wahidin Sudirohusodo hospital.
 Methods: A Descriptive study. Study population was all outpatients at Pediatric Growth and Development polyclinic, Wahidin Sudirohusodo hospital in Makassar 2015-2019. Samples in this study were collected from total sampling of population data that met the criteria of new Down syndrome patients with complete medical records
 Results: This study found 237 new pediatric down syndrome patients admitted to growth and development polyclinic from January 2015 – December 2019, 95 complete medical records from 237. 52% (49) boys, 48 % (46) girls from 95 children. No gender difference was found in the presentation. Parental age of Down syndrome patients, the most advanced maternal age was >35, found 46 (48,42%), the most advanced paternal age was >35, found 63 (66,32%). Parity < 3rd, the most maternal age between 25-35 (23,16%), parity > 3rd, the most maternal age was >34, found 30 (31,57%).
 Conclusion. Advance maternal and/ or paternal age is a risk factor of Down Syndrome.

Cytotoxic T-lymphocyte-associated protein 4 +49A/G polymorphism in Down syndrome children with Hashimoto’s thyroiditis

“…In our study population, the proportion of boys was greater than that of girls, which was similar to the findings of Musdalipa et al and Kawanto et al [ 46 , 50 ]. However, Guaraldi et al pointed out that there is no difference in the rate of HT between sexes [ 51 ].…”

“…Subclinical hypothyroidism was the most common thyroid dysfunction in DS children with HT, which is commonly asymptomatic and may not require treatment. However, subclinical hypothyroidism can progress to primary hypothyroidism associated with autoimmune factors [34][35][36][37][38][39][40][41][42][43][44][45][46][47]. TgAb positivity was more prevalent compared to TPOAb positivity, as observed in our study.…”

Identification of maternal risk factors for having Down syndrome cases in Jordan

“…Interestingly, when comparing age categories, we found that older females (35 years and above) were approximately 2 times more likely to have a child with DS compared to younger females (below 35 years). This result is supported by previous ndings indicating an increased risk of DS with advancing maternal age(Morris et al, 2003b;Musdalipa et al, 2021).Furthermore, this study examined the impact of previous miscarriages on the risk of conceiving a child with DS. Interestingly, individuals who had experienced previous miscarriages were approximately 12 times more likely to have a child with DS compared to those without a history of miscarriage.…”