Materials design for bone-tissue engineering

Koons, Gerry L.; Diba, Mani; Mikos, Antonios G.

doi:10.1038/s41578-020-0204-2

Cited by 1,056 publications

(834 citation statements)

References 293 publications

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“…In combination with medical imaging techniques, three dimensional (3D) printing technologies [6][7][8][9][10][11][12][13] , such as digital light processing (DLP) 14 , provide enormous opportunities for rapid and affordable production of personalized medical devices [15][16][17][18][19] , including airway stents 5 . This specific manufacturing technology is based on the localized light-initiated photopolymerization of a liquid resin containing (macro)monomers 6,20 .…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional Printing of Customized Bioresorbable Airway Stents

Paunović

Bao

Coulter

et al. 2020

Preprint

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Central airway obstruction is a life-threatening disorder causing a high physical and psychological burden to patients due to severe breathlessness and impaired quality of life. Standard-of-care airway stents are silicone tubes, which cause immediate relief, but are prone to migration, especially in growing patients, and require additional surgeries to be removed, which may cause further tissue damage. Customized airway stents with tailorable bioresorbability that can be produced in a reasonable time frame would be highly needed in the management of this disorder. Here, we report poly(D,L lactide-co-ε-caprolactone) methacrylate blends based biomedical inks and their use for the rapid fabrication of customized and bioresorbable airway stents. The 3D printed materials are cytocompatible and exhibit silicone-like mechanical properties with suitable biodegradability. In vivo studies in healthy rabbits confirmed biocompatibility and showed that the stents stayed in place for 7 weeks after which they became radiographically invisible. The developed biomedical inks open promising perspectives for the rapid manufacturing of the customized medical devices for which high precision, tuneable elasticity and predictable degradation are sought after.

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Section: Introductionmentioning

confidence: 99%

Three-dimensional Printing of Customized Bioresorbable Airway Stents

Paunović

Bao

Coulter

et al. 2020

Preprint

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“…Of the many different types of collagen, type-I collagen is the most abundant and forms the main structures of mineralized tissues as well as soft tissues such as ligaments, including PDLs or gingiva fibrous tissues in dental and craniofacial tissue complexes [ 2 , 38 , 65 ]. In particular, the formation of calcium-phosphate crystals within the collagen fibrils, as the mineralized tissue develops, endows them with mechanical properties such as load bearing ability, tensile strength, and torsional stiffness [ 66 , 67 , 68 ].…”

Section: Natural Biopolymers For Periodontal Hard Tissue Regeneratmentioning

confidence: 99%

Tooth-Supporting Hard Tissue Regeneration Using Biopolymeric Material Fabrication Strategies

Kim

Park

2020

Molecules

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The mineralized tissues (alveolar bone and cementum) are the major components of periodontal tissues and play a critical role to anchor periodontal ligament (PDL) to tooth-root surfaces. The integrated multiple tissues could generate biological or physiological responses to transmitted biomechanical forces by mastication or occlusion. However, due to periodontitis or traumatic injuries, affect destruction or progressive damage of periodontal hard tissues including PDL could be affected and consequently lead to tooth loss. Conventional tissue engineering approaches have been developed to regenerate or repair periodontium but, engineered periodontal tissue formation is still challenging because there are still limitations to control spatial compartmentalization for individual tissues and provide optimal 3D constructs for tooth-supporting tissue regeneration and maturation. Here, we present the recently developed strategies to induce osteogenesis and cementogenesis by the fabrication of 3D architectures or the chemical modifications of biopolymeric materials. These techniques in tooth-supporting hard tissue engineering are highly promising to promote the periodontal regeneration and advance the interfacial tissue formation for tissue integrations of PDL fibrous connective tissue bundles (alveolar bone-to-PDL or PDL-to-cementum) for functioning restorations of the periodontal complex.

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“…The bone is considered as a complex tissue comprised of hierarchical structure which offer protection for internal organs, support body and facilitates movement, therefore repairing their defects holds paramount importance in the clinical significance. Generally, transplantation is opted to treat the bone defects by using autografts and allografts, however several associated drawbacks exit with regard to donors, availability of autologous bones in the body and immune rejection [109][110][111]. Therefore, in recent years bone tissue engineering have advanced the treatment using several biocompatible materials that has structural and functional interface to remodel the bone defects.…”

Section: Bone Tissue Engineeringmentioning

confidence: 99%

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

Balusamy

Anitha

Uyar

2020

Hacettepe Journal of Biology and Chemistry

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E lektro-eğirme yöntemi ile üretilen nanolifler, son yıllarda nanofibröz yapı iskelelerinin geliştirilmesinde büyük ilgi gördü ve biyomimetik yapıları nedeniyle farklı biyomedikal uygulamalarda kullanıldı. Özellikle, elektro-eğirme yöntemi ile üretilen nanolifler doğal hücre dışı matris (ECM), birbirine bağlı gözenekler, geniş yüzey alanı, işlevselleştirme kolaylığı ve hücre adezyonunu, farklılaşmasını ve proliferasyon davranışını etkilemede büyük önem taşıyan mekanik performans dahil olmak üzere birçok faydalı özellik sergiler. Bugüne kadar, çok çeşitli yararlı özellikleri kabul eden bu nanolifler, yara örtüsü ve doku mühendisliği uygulamalarında kullanılmıştır. Bu derlemede, çeşitli malzemelerin ve yaklaşımların kullanımını gösteren birkaç temsili örneklerle bu alanlarda çeşitli çabaların yapıldığını özetlemektedir. Ayrıca, klinik faz transferine ilişkin gelecekteki yön endişeleri tartışılmıştır. Anahtar Kelimeler Elektro-eğirme, nanolif, yara örtüsü, doku mühendisliği.

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Materials design for bone-tissue engineering

Cited by 1,056 publications

References 293 publications

Three-dimensional Printing of Customized Bioresorbable Airway Stents

Three-dimensional Printing of Customized Bioresorbable Airway Stents

Tooth-Supporting Hard Tissue Regeneration Using Biopolymeric Material Fabrication Strategies

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

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