Materials Based on Chitosan and Polylactide: From Biodegradable Plastics to Tissue Engineering Constructions

Abstract

The transition to green chemistry and biodegradable polymers is a logical stage in the development of modern chemical science and technology. In the framework of this review, the advantages, disadvantages, and potential of biodegradable polymers of synthetic and natural origin are compared using the example of polylactide and chitosan as traditional representatives of these classes of polymers, and the possibilities of their combination via obtaining composite materials or copolymers are assessed. The mechanochemical approach to the synthesis of graft copolymers of chitosan with oligolactides/polylactides is considered in more detail.

pH-Responsive Liquid Marbles Stabilized with Chitosan-Stearic Acid-Conjugated Particles

“…The shell thicknesses increased with increases in the amount of SA used for the amidation reaction (Figure S6). The melting point of the CS was >250 °C (see above); therefore, the CS particles maintained their particulate shapes, and the amidation reaction proceeded gradually from the surfaces of the CS particles.…”

“…This occurred because the modification reaction was conducted at 145 °C, which was below the melting point of CS (DSC studies of our CS particles did not show the melting point, which might be because the melting point was higher than the maximum temperature used for the measurement, 250 °C. CS forms intramolecular and intermolecular hydrogen bonds, which make the polymer chains rigid, resulting in a melting point higher than the decomposition temperature 78 ). FT-IR studies were conducted to identify the functional groups on the modified CS particles (Figure 4).…”

Biodegradable Microparticles for Regenerative Medicine: A State of the Art and Trends to Clinical Application

“…Biodegradable synthetic aliphatic polyesters are the main class of raw materials reported for the fabrication of polymeric scaffolds and drug delivery systems [ 11 , 12 , 13 ]. Being approved for more than 30 years by regulatory bodies, e.g., FDA or EMA, aliphatic polyesters, such as poly(lactic acid) (PLA), poly(glycolic acid) (PLGA), polycaprolactone (PCL), and their copolymers, have received the most considerable attention.…”