Biodegradable Microparticles for Regenerative Medicine: A State of the Art and Trends to Clinical Application

Sherstneva, Anastasia A.; Демина, Т. С.; Monteiro, Ana P. F.; Акопова, Т. А.; Grandfils, Christian; Ilangala, Ange B.

doi:10.3390/polym14071314

Cited by 14 publications

(9 citation statements)

References 163 publications

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“…The typical process of producing microparticles involves gel formation, emulsification, spray drying, and heat treatment [ 12 ]. For instance, caseins form gels with polysaccharides (gum, carboxymethyl cellulose, and pectin), which can also be used for encapsulation of bioactive compounds [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Transglutaminase Post-Treatment on the Stability and Swelling Behavior of Casein Micro-Particles

Gebhardt

Khanna

Schulte

et al. 2022

IJMS

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Casein microparticles are produced by flocculation of casein micelles due to volume exclusion of pectin and subsequent stabilization by film drying. Transglutaminase post-treatment alters their stability, swelling behavior, and internal structure. Untreated particles sediment due to their size and disintegrate completely after the addition of sodium dodecyl sulfate. The fact that transglutaminase-treated microparticles only sediment at comparable rates under these conditions shows that their structural integrity is not lost due to the detergent. Transglutaminase-treated particles reach an equilibrium final size after swelling instead of decomposing completely. By choosing long treatment times, swelling can also be completely suppressed as experiments at pH 11 show. In addition, deswelling effects also occur within the swelling curves, which enhance with increasing transglutaminase treatment time and are ascribed to the elastic network of cross-linked caseins. We propose a structural model for transglutaminase-treated microparticles consisting of a core of uncross-linked and a shell of cross-linked caseins. A dynamic model describes all swelling curves by considering both casein fractions in parallel. The characteristic correlation length of the internal structure of swollen casein microparticles is pH-independent and decreases with increasing transglutaminase treatment time, as observed also for the equilibrium swelling value of uncross-linked caseins.

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Section: Introductionmentioning

confidence: 99%

Effect of Transglutaminase Post-Treatment on the Stability and Swelling Behavior of Casein Micro-Particles

Gebhardt

Khanna

Schulte

et al. 2022

IJMS

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“…Silk-based microparticle systems have been explored over the last decades as a result of their stability, drug-loading capacities, ease of handling (often compared with conventional manufacturing processes), tissue penetration, and ease of functionalization [ 90 ].…”

Section: Particulate Drug Delivery Systems In Wound and Skin Regenera...mentioning

confidence: 99%

Sustainable Silk-Based Particulate Systems for the Controlled Release of Pharmaceuticals and Bioactive Agents in Wound Healing and Skin Regeneration

Bernardes,

Veiga,

Barros

et al. 2024

IJMS

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The increasing demand for innovative approaches in wound healing and skin regeneration has prompted extensive research into advanced biomaterials. This review focuses on showcasing the unique properties of sustainable silk-based particulate systems in promoting the controlled release of pharmaceuticals and bioactive agents in the context of wound healing and skin regeneration. Silk fibroin and sericin are derived from well-established silkworm production and constitute a unique biocompatible and biodegradable protein platform for the development of drug delivery systems. The controlled release of therapeutic compounds from silk-based particulate systems not only ensures optimal bioavailability but also addresses the challenges associated with conventional delivery methods. The multifaceted benefits of silk proteins, including their inherent biocompatibility, versatility, and sustainability, are explored in this review. Furthermore, the intricate mechanisms by which controlled drug release takes place from silk-based carriers are discussed.

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“…The formulation of PLGA microparticles can be realized by a variety of methods including emulsion solvent evaporation [ 12 ] or diffusion [ 13 ], coacervation [ 14 ], spray drying [ 15 ], microfluidics [ 16 ], and many other approaches [ 17 ]. Of these methods, spray drying is the most commonly, also commercially, used manufacturing method due to its reproducibility, scalability, and cost-effectiveness [ 18 , 19 ]. Microfluidic devices are currently gaining attention due to the mild processing conditions, scalability, and precise control over the resulting particle size and shape [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

In situ Formation of Polymer Microparticles in Bacterial Nanocellulose Using Alternative and Sustainable Solvents to Incorporate Lipophilic Drugs

et al. 2023

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Bacterial nanocellulose has been widely investigated in drug delivery, but the incorporation of lipophilic drugs and controlling release kinetics still remain a challenge. The inclusion of polymer particles to encapsulate drugs could address both problems but is reported sparely. In the present study, a formulation approach based on in situ precipitation of poly(lactic-co-glycolic acid) within bacterial nanocellulose was developed using and comparing the conventional solvent N-methyl-2-pyrrolidone and the alternative solvents poly(ethylene glycol), CyreneTM and ethyl lactate. Using the best-performing solvents N-methyl-2-pyrrolidone and ethyl lactate, their fast diffusion during phase inversion led to the formation of homogenously distributed polymer microparticles with average diameters between 2.0 and 6.6 µm within the cellulose matrix. Despite polymer inclusion, the water absorption value of the material still remained at ~50% of the original value and the material was able to release 32 g/100 cm2 of the bound water. Mechanical characteristics were not impaired compared to the native material. The process was suitable for encapsulating the highly lipophilic drugs cannabidiol and 3-O-acetyl-11-keto-β-boswellic acid and enabled their sustained release with zero order kinetics over up to 10 days. Conclusively, controlled drug release for highly lipophilic compounds within bacterial nanocellulose could be achieved using sustainable solvents for preparation.

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Biodegradable Microparticles for Regenerative Medicine: A State of the Art and Trends to Clinical Application

Cited by 14 publications

References 163 publications

Effect of Transglutaminase Post-Treatment on the Stability and Swelling Behavior of Casein Micro-Particles

Effect of Transglutaminase Post-Treatment on the Stability and Swelling Behavior of Casein Micro-Particles

Sustainable Silk-Based Particulate Systems for the Controlled Release of Pharmaceuticals and Bioactive Agents in Wound Healing and Skin Regeneration

In situ Formation of Polymer Microparticles in Bacterial Nanocellulose Using Alternative and Sustainable Solvents to Incorporate Lipophilic Drugs

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