Mastocytosis. Report of a case in a 15 and one-half-week-old infant with cutaneous and generalized skeletal changes.

Cole, A

doi:10.1136/adc.40.214.677

Cited by 4 publications

(4 citation statements)

References 17 publications

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“…Cutaneous features (Fig. e and Table S1) were reported in 70% of cases in the series . Darier sign was present in 90% of patients.…”

Section: Resultsmentioning

confidence: 80%

“…However, the criteria for anaphylaxis were rarely described in these studies. Data on personal or familial history of atopic dermatitis or asthma were available for 507 patients, and positive in 14% ( n = 73) . Caplan found 47% of cases with a familial or personal history of atopy, unlike Azaña et al ., who reported only 6% of patients with atopy.…”

Section: Resultsmentioning

confidence: 99%

“…In total 90 articles were available. This included 43 series, 21 case reports with outcome data (> 3 years), 15 articles involving twins (one of which was also included in the 43 series), corresponding to 31 cases and 12 articles concerning MCL or MCS, corresponding to 12 cases (two concerning the same patients) . A two‐generation history of mastocytosis was mandatory for the positive familial history criterion.…”

Section: Methodsmentioning

confidence: 99%

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Paediatric mastocytosis: a systematic review of 1747 cases

et al. 2015

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Paediatric mastocytosis was previously considered to be a benign and spontaneously regressing disease. However, this evolution is impossible to predict. To clarify the characteristics and course of paediatric mastocytosis, we performed a literature review of 1747 cases published between 1950 and April 2014. Lesions occurred before the age of 2 years in 90% of cases, and presented as urticaria pigmentosa (75% of cases), mastocytoma (20%) or diffuse cutaneous mastocytosis (5%). The male-to-female ratio was 1·4. KIT D816V mutation was detected in 34% of 215 tested patients. Clinical regression (complete or partial) occurred in 67% of cases and stabilization in 27%. However, the outcome was fatal in 2·9% of patients.

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“…Cutaneous features (Fig. e and Table S1) were reported in 70% of cases in the series . Darier sign was present in 90% of patients.…”

Section: Resultsmentioning

confidence: 80%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Paediatric mastocytosis: a systematic review of 1747 cases

et al. 2015

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“…Smith described a child with DCM and recurrent gastrointestinal bleeding associated with a prolonged coagulation time (9). In 1965 Cole described an infant with mastocytosis and generalized skeletal changes (10). Ofthe eight patients reviewed by Harrison et al (5), three died, one as a result of extensive blistering and infection, one from mast cell leukemia, and the third from an unknown cause.…”

Section: Discussionmentioning

confidence: 99%

Diffuse Cutaneous Mastocytosis Mimicking Staphylococcal Scalded‐Skin Syndrome: Report of Three Cases

Oranje

Soekanto

Sukardi³

et al. 1991

Pediatric Dermatology

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Three cases of diffuse cutaneous mastocytosis (DCM) were at first incorrectly diagnosed as staphylococcal scalded-skin syndrome. In the first patient, at age 1 day the disease was recognized promptly by simple techniques such as Darier's sign and Tzanck smear. Much delay in making the diagnosis occurred in the other two patients, however: almost 1 year and 15 years, respectively. Bullous manifestations in mastocytosis occur only in the first two or three years. In the first months the disease can be dangerous and life threatening. To distinguish mastocytosis from vesicular and bullous neonatal disorders, one should perform Darier's sign and a Tzanck smear. The diagnosis is confirmed by histopathologic studies. Treatment of the bullous manifestations is symptomatic, with zinc oxide paste and oral antihistamines, which may provide some relief. In addition, cimetidine and sodium cromoglycate may be beneficial. At a later age psoralen plus ultraviolet A therapy may also relieve the symptoms. Particular foods and medicines can liberate histamine and should be restricted as much as possible in extremely affected patients. Special care should be taken when these patients are to undergo anesthesia. The risk of complications during and after anesthesia is also present in other forms of mastocytosis.

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Solitary Mastocytoma

Holmberg

1970

Acta Paediatrica

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Mastocytosis. Report of a case in a 15 and one-half-week-old infant with cutaneous and generalized skeletal changes.

Cited by 4 publications

References 17 publications

Paediatric mastocytosis: a systematic review of 1747 cases

Paediatric mastocytosis: a systematic review of 1747 cases

Diffuse Cutaneous Mastocytosis Mimicking Staphylococcal Scalded‐Skin Syndrome: Report of Three Cases

Solitary Mastocytoma

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