Mast cells in liver disease progression: An update on current studies and implications

Pham, Linh; Kennedy, Lindsey; Baiocchi, Leonardo; Meadows, Vik; Ekser, Burçin; Kundu, Debjyoti; Zhou, Tianhao; Sato, Keisaku; Glaser, Shannon; Ceci, Ludovica; Alpini, Gianfranco; Francis, Heather

doi:10.1002/hep.32121

Cited by 13 publications

(11 citation statements)

References 48 publications

(63 reference statements)

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“…MC presence has been shown to be associated with poor prognosis and aggressive disease in diverse cancer types including Hodgkin lymphoma ( 18 ), pancreatic adenocarcinoma ( 19, 20 ), hepatocellular carcinoma (HCC, ref. 21 ), and cholangiocarcinoma ( 22 ). In patients with Hodgkin lymphoma, MC infiltration is predictive of worse relapse-free survival rates ( 18 ).…”

Section: The Ambiguous Role Of Mcs In Cancermentioning

confidence: 99%

Few, but Efficient: The Role of Mast Cells in Breast Cancer and Other Solid Tumors

Majorini¹,

Colombo²,

Lecis

2022

Cancer Research

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Tumor outcome is determined not only by cancer cell-intrinsic features but also by the interaction between cancer cells and their microenvironment. There is great interest in tumor infiltrating immune cells, yet mast cells have been less studied. Recent work has highlighted the impact of mast cells on the features and aggressiveness of cancer cells, but the eventual effect of mast cell infiltration is still controversial. Here, we review multifaceted findings regarding the role of mast cells in cancer, with a particular focus on breast cancer, which is further complicated due to its classification into subtypes characterized by different biological features, outcome, and therapeutic strategies.

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Section: The Ambiguous Role Of Mcs In Cancermentioning

confidence: 99%

Few, but Efficient: The Role of Mast Cells in Breast Cancer and Other Solid Tumors

Majorini¹,

Colombo²,

Lecis

2022

Cancer Research

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“…These observations, as well as studies on other tumors, suggest that IL-6 plays an important role in the link between chronic inflammation and cancer, thus supporting this molecule as a possible target for anticancer therapy [73]. Histamine (HA) has been implicated to play a role in both PSC and CCA progression and studies have demonstrated that patients with PSC and CCA have increased HA serum content, therefore, this neurohormone has been targeted as a potential risk factor [74]. In fact, when nu/nu mice were implanted with Mz-ChA-1 cells (a subcutaneous xenograft CCA in vivo model) and treated with exogenous HA, tumor growth exponentially increased compared to controls; however, when HA was removed from Mz-ChA-1 cells using stable shRNA transfection prior to implantation, tumors were remarkably smaller compared to controls, suggesting that HA promotes tumor growth [75].…”

Section: From Psc To Ccamentioning

confidence: 93%

Molecular Mechanisms Linking Risk Factors to Cholangiocarcinoma Development

Ceci

Zhou

Lenci

et al. 2022

Cancers

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The poor prognosis of cholangiocarcinoma in humans is related to several factors, such as (i) the heterogeneity of the disease, (ii) the late onset of symptoms and (iii) the limited comprehension of the carcinogenic pathways determining neoplastic changes, which all limit the pursuit of appropriate treatment. Several risk factors have been recognized, including different infective, immune-mediated, and dysmorphogenic disorders of the biliary tree. In this review, we report the details of possible mechanisms that lead a specific premalignant pathological condition to become cholangiocarcinoma. For instance, during liver fluke infection, factors secreted from the worms may play a major role in pathogenesis. In primary sclerosing cholangitis, deregulation of histamine and bile-acid signaling may determine important changes in cellular pathways. The study of these molecular events may also shed some light on the pathogenesis of sporadic (unrelated to risk factors) forms of cholangiocarcinoma, which represent the majority (nearly 75%) of cases.

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“…Mast cells, a kind of inflammatory cell capable of releasing histamine and other particles, are emerging as novel participants in cholangiopathies ( 117 ). The infiltration of mast cells was detected in close proximity to cholangiocytes during cholestasis, PSC, PBC, and CCA ( 118 – 120 ).…”

Section: Crosstalk Between the Immune System And Biliary Repairmentioning

confidence: 99%

“…The infiltration of mast cells was detected in close proximity to cholangiocytes during cholestasis, PSC, PBC, and CCA ( 118 – 120 ). In vivo studies using antagonists and gene knockout mouse models further revealed a mast cell-mediated histamine-tissue growth factor-β (TGF-β)/stem cell factor (SCF) axis in the pathogenesis of PSC and CCA ( 117 , 121 ). Concerning biliary repair, mast cells mainly regulate cholangiocyte proliferation.…”

Section: Crosstalk Between the Immune System And Biliary Repairmentioning

confidence: 99%

Role of Immune Cells in Biliary Repair

et al. 2022

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The biliary system is comprised of cholangiocytes and plays an important role in maintaining liver function. Under normal conditions, cholangiocytes remain in the stationary phase and maintain a very low turnover rate. However, the robust biliary repair is initiated in disease conditions, and different repair mechanisms can be activated depending on the pathological changes. During biliary disease, immune cells including monocytes, lymphocytes, neutrophils, and mast cells are recruited to the liver. The cellular interactions between cholangiocytes and these recruited immune cells as well as hepatic resident immune cells, including Kupffer cells, determine disease outcomes. However, the role of immune cells in the initiation, regulation, and suspension of biliary repair remains elusive. The cellular processes of cholangiocyte proliferation, progenitor cell differentiation, and hepatocyte-cholangiocyte transdifferentiation during biliary diseases are reviewed to manifest the underlying mechanism of biliary repair. Furthermore, the potential role of immune cells in crucial biliary repair mechanisms is highlighted. The mechanisms of biliary repair in immune-mediated cholangiopathies, inherited cholangiopathies, obstructive cholangiopathies, and cholangiocarcinoma are also summarized. Additionally, novel techniques that could clarify the underlying mechanisms of biliary repair are displayed. Collectively, this review aims to deepen the understanding of the mechanisms of biliary repair and contributes potential novel therapeutic methods for treating biliary diseases.

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Mast cells in liver disease progression: An update on current studies and implications

Cited by 13 publications

References 48 publications

Few, but Efficient: The Role of Mast Cells in Breast Cancer and Other Solid Tumors

Few, but Efficient: The Role of Mast Cells in Breast Cancer and Other Solid Tumors

Molecular Mechanisms Linking Risk Factors to Cholangiocarcinoma Development

Role of Immune Cells in Biliary Repair

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