Few, but Efficient: The Role of Mast Cells in Breast Cancer and Other Solid Tumors

Majorini, Maria Teresa; Colombo, Mario P.; Lecis, Daniele

doi:10.1158/0008-5472.can-21-3424

Cited by 24 publications

(17 citation statements)

References 110 publications

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“…On the other hand, some studies signal the involvement of MCs in tumor cell proliferation and spreading. In an animal model of BrCa, it was noticed that MCs stimulate tumor growth and limit the development of the basal CK5 compartment [25].…”

Section:  Discussionmentioning

confidence: 99%

Mast cell density in the primary tumor predicts lymph node metastases in patients with breast cancer

Floroni

Ceauşu²,

Cosoroabă³

et al. 2022

Rom J Morphol Embryol

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Breast cancer (BrCa) is the most frequent neoplastic disease in female, with high morbidity and mortality. Most of the researches were focused on tumor cells concerning their natural evolution, molecular profile, and potential response to therapy. Few and uncertain data are available about the tumor microenvironment and its impact on the progression of the disease. Mast cells (MCs) associated to BrCa have been reported many years ago, but their real and specific role in the biology of this disease remained elusive. In the current study, we have investigated the predictive role of MCs from the primary tumor on lymph node metastasis on patients stratified based on the molecular classification. We investigated 156 patients with BrCa, stratified as luminal A, luminal B, human epidermal growth factor receptor 2 (HER2) type, basal-like, and unclassified. MCs were identified with anti-MC tryptase antibody in a double immunohistochemical reaction combined with anti-cluster of differentiation 34 (CD34) antibody. Mast cell density (MCD) was calculated based on the hot-spot method, on three fields with maximum density of MCs in each case. The final result was the arithmetic media that was compared with the molecular profile and lymph node metastases. We found no significant correlation between MCD and the molecular profile of the primary tumor, but we noticed a strong correlation between intratumor MCD and lymph node metastases, regardless of the molecular type.

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Section:  Discussionmentioning

confidence: 99%

Mast cell density in the primary tumor predicts lymph node metastases in patients with breast cancer

Floroni

Ceauşu²,

Cosoroabă³

et al. 2022

Rom J Morphol Embryol

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“…Mast cells (MCs) are master players in allergic inflammation and immune defense against certain parasites or bacteria (69), but have also been involved in autoimmunity (70) and cancer (71). Mast cells release ETs of DNA decorated with histones, cytoplasmic or granular proteins such as tryptase (72), the anti-microbial peptide LL-37 (72) or b-hexosaminidase (73), in response to several stimuli including PMA (72,73), hydrogen peroxide (72), monosodium urate crystals (74) or exposure to pathogens such as Streptococcus pyogenes (72), Listeria Monocytogenes (73), Leishmania (75), Mycobacterium tuberculosis (76).…”

Section: Mast Cellsmentioning

confidence: 99%

Unveiling Leukocyte Extracellular Traps in Inflammatory Responses of the Central Nervous System

Colciaghi

Costanza

2022

Front. Immunol.

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Over the past nearly two decades, increasing evidence has uncovered how immune cells can actively extrude genetic material to entrap invading pathogens or convey sterile inflammatory signals that contribute to shaping immune responses. Originally identified in neutrophils, the release of decondensed chromatin fibers decorated with antimicrobial proteins, called extracellular traps (ETs), has been recognized as a specific form of programmed inflammatory cell death, which is now known to occur in several other leukocytes. Subsequent reports have shown that self-DNA can be extruded from immune cells even in the absence of cell death phenomena. More recent data suggest that ETs formation could exacerbate neuroinflammation in several disorders of the central nervous system (CNS). This review article provides an overview of the varied types, sources, and potential functions of extracellular DNA released by immune cells. Key evidence suggesting the involvement of ETs in neurodegenerative, traumatic, autoimmune, and oncological disorders of the CNS will be discussed, outlining ongoing challenges and drawing potentially novel lines of investigation.

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“…In addition, MCs are associated with a range of other types of pathological conditions, including arthritis, diabetes, cardiovascular complications and they are also implicated in cancer 3 . A role of MCs in cancer was originally suggested based on clinical observations of extensive MC infiltration in tumor settings such as breast cancer, lung cancer, pancreatic cancer, Hodgkin's lymphoma, prostate cancer and malignant melanoma [4][5][6][7][8] . In these conditions, MCs typically accumulate in large numbers in the tumor stroma, but they can also be found, although usually in lower amounts, in the tumor parenchyma [4][5][6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

“…A role of MCs in cancer was originally suggested based on clinical observations of extensive MC infiltration in tumor settings such as breast cancer, lung cancer, pancreatic cancer, Hodgkin's lymphoma, prostate cancer and malignant melanoma [4][5][6][7][8] . In these conditions, MCs typically accumulate in large numbers in the tumor stroma, but they can also be found, although usually in lower amounts, in the tumor parenchyma [4][5][6][7][8] .…”

Section: Introductionmentioning

confidence: 99%

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Phenotypic switch and reduced the growth of melanoma spheroids in the presence of mast cell-conditioned medium: potential impact of nutrient starvation effects

Grujić

Nguyen

Hechard

et al. 2022

Preprint

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Mast cells are abundant in melanoma tumors, and studies suggest that they can be either detrimental or protective for melanoma growth. However, the underlying mechanisms are not fully understood. Here, we adopted a hanging drop-established spheroid system to investigate how mast cells can influence melanoma growth and phenotype in a 3-D context. In the presence of mast cells or mast cell-conditioned medium, melanoma spheroid growth was profoundly reduced. To address the underlying mechanism, we conducted a transcriptomic analysis, which revealed that mast cell-conditioned medium had extensive effects on the melanoma gene expression patterns. Pathway analyses revealed profound effects on the expression of genes related to amino acid and protein metabolism. The conditioned medium also induced an upregulated expression of cancer-related genes, including adhesion molecules implicated in metastatic spreading. In line with this, after transfer to a Matrigel extracellular matrix milieu, spheroids that had been developed in the presence of mast cell-conditioned medium displayed enhanced elevated growth and adhesive properties. However, when assessing for possible effects of nutrient starvation, i.e., reduced nutrient content in mast cell-conditioned medium, we found that the observed effects on melanoma spheroid growth potentially could be explained by such effects. Hence, it cannot be excluded that the observed phenotypic alterations of melanoma spheroids grown in the presence of mast cells or mast cell-conditioned media are, at least partly, due to nutrient starvation rather than to the action of factors secreted by mast cells. Instead, our findings may provide insight into the effects on gene expression events that occur in melanoma tumors under nutrient stress.

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Few, but Efficient: The Role of Mast Cells in Breast Cancer and Other Solid Tumors

Cited by 24 publications

References 110 publications

Mast cell density in the primary tumor predicts lymph node metastases in patients with breast cancer

Mast cell density in the primary tumor predicts lymph node metastases in patients with breast cancer

Unveiling Leukocyte Extracellular Traps in Inflammatory Responses of the Central Nervous System

Phenotypic switch and reduced the growth of melanoma spheroids in the presence of mast cell-conditioned medium: potential impact of nutrient starvation effects

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