Mast cells and aging

Kutukova, N.; Nazarov, Peter G.; Kudryavtseva, G. V.; Shishkin, V. V.

doi:10.1134/s207905701701009x

Cited by 5 publications

(3 citation statements)

References 58 publications

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“…The number of mast cells increased around papillary dermis after UVB radiation although UVB rays cannot reach these area [31]. During this response, stem cell factor (SCF) lead to mast cells increase as well as neuropeptides from activated nerve ending promote mast cell degranulation [32,33]. Also, trypase secreted from mast cells during degranulation trigger the activation of MMPs and sequentially induce degradation of ECM proteins in dermis of skin [34].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Cold-Pressed Perilla Oil Mainly Consisting of Linolenic acid, Oleic Acid and Linoleic Acid on UV-Induced Photoaging in NHDF Cells and SKH-1 Hairless Mice

et al. 2020

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Positive physiological benefits of several plant oils on the UV-induced photoaging have been reported in some cell lines and model mice, but perilla oil collected from the seeds of Perilla frutescens L. has not been investigated in this context. To study the therapeutic effects of cold-pressed perilla oil (CPO) on UV-induced photoaging in vitro and in vivo, UV-induced cellular damage and cutaneous photoaging were assessed in normal human dermal fibroblasts (NHDFs) and HR-1 hairless mice. CPO contained five major fatty acids including linolenic acid (64.11%), oleic acid (16.34%), linoleic acid (11.87%), palmitic acid (5.06%), and stearic acid (2.48%). UV-induced reductions in NHDF cell viability, ROS production, SOD activity, and G2/M cell cycle arrest were remarkably improved in UV + CPO treated NHDF cells as compared with UV + Vehicle treated controls. Also, UV-induced increases in MMP-1 protein and galactosidase levels were remarkably suppressed by CPO. In UV-radiated hairless mice, topical application of CPO inhibited an increase in wrinkle formation, transepidermal water loss (TEWL), erythema value, hydration and melanin index on dorsal skin of UVB-irradiated hairless mice. CPO was observed to similarly suppress UV-induced increases in epidermal thickness, mast cell numbers, and galactosidase and MMP-3 mRNA levels. These results suggest CPO has therapeutic potential in terms of protecting against skin photoaging by regulating skin morphology, histopathology and oxidative status.

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Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Cold-Pressed Perilla Oil Mainly Consisting of Linolenic acid, Oleic Acid and Linoleic Acid on UV-Induced Photoaging in NHDF Cells and SKH-1 Hairless Mice

et al. 2020

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“…Increased inflammation is central to CNS pathologies. Aging affects MCs (Gunin et al, 2011;Chatterjee and Gashev, 2012;Kutukova et al, 2016) and has been reported to be proinflammatory (Elbasiony et al, 2023) during aging. As Mitf is also required for MC function, Mitf heterozygous mice might be more applicable for studies of meningeal MCs during aging in comparison to other MC models, which are limited due to the absence or reduced number of MCs.…”

Section: Discussionmentioning

confidence: 99%

Absence of meningeal mast cells in the Mitf mutant mouse

Sabaté San José,

Petersen

2024

Front. Cell. Neurosci.

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Mast cells (MCs) are located in the meninges of the central nervous system (CNS), where they play key roles in the immune response. MC-deficient mice are advantageous in delineating the role of MCs in the immune response in vivo. In this study, we illustrate that a mutation in microphthalmia-associated transcription factor (Mitf) affects meningeal MC number in a dosage-dependent manner. C57BL/6J Mitf null mice lack meningeal MCs completely, whereas heterozygous mice have on average 25% fewer MCs. Mitf heterozygous mice might be a valuable tool to study the role of MCs in the meninges.

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“…MCs are about 2–3% of the immune cellular pool of the lamina propria, and in the muscular and serous layers (3000–25,000 MCs/mm 3 ) [ 10 ]. Variations in the number of MCs are observed in the elderly, as with aging there are changes in connective and mucous tissues as well as other changes closely related to CNS disorders, including depression and anxiety [ 95 ]. An increase in the number of MCs during aging has also been observed in human organs and organs of other mammals and vertebrate animals.…”

Section: Focus On Mast Cells Sars-cov-2 and Microbiotamentioning

confidence: 99%

The Connection between Gut and Lung Microbiota, Mast Cells, Platelets and SARS-CoV-2 in the Elderly Patient

Traina

2022

IJMS

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The human coronavirus SARS-CoV-2 or COVID-19 that emerged in late 2019 causes a respiratory tract infection and has currently resulted in more than 627 million confirmed cases and over 6.58 million deaths worldwide up to October 2022. The highest death rate caused by COVID-19 is in older people, especially those with comorbidities. This evidence presents a challenge for biomedical research on aging and also identifies some key players in inflammation, including mast cells and platelets, which could represent important markers and, at the same time, unconventional therapeutic targets. Studies have shown a decrease in the diversity of gut microbiota composition in the elderly, particularly a reduced abundance of butyrate-producing species, and COVID-19 patients manifest faecal microbiome alterations, with an increase in opportunistic pathogens and a depletion of commensal beneficial microorganisms. The main purpose of this narrative review is to highlight how an altered condition of the gut microbiota, especially in the elderly, could be an important factor and have a strong impact in the lung homeostasis and COVID-19 phenomenon, jointly to the activation of mast cells and platelets, and also affect the outcomes of the pathology. Therefore, a targeted and careful control of the intestinal microbiota could represent a complementary intervention to be implemented for the management and the challenge against COVID-19.

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Mast cells and aging

Cited by 5 publications

References 58 publications

Therapeutic Effects of Cold-Pressed Perilla Oil Mainly Consisting of Linolenic acid, Oleic Acid and Linoleic Acid on UV-Induced Photoaging in NHDF Cells and SKH-1 Hairless Mice

Therapeutic Effects of Cold-Pressed Perilla Oil Mainly Consisting of Linolenic acid, Oleic Acid and Linoleic Acid on UV-Induced Photoaging in NHDF Cells and SKH-1 Hairless Mice

Absence of meningeal mast cells in the Mitf mutant mouse

The Connection between Gut and Lung Microbiota, Mast Cells, Platelets and SARS-CoV-2 in the Elderly Patient

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