Marrow-derived mesenchymal stem cells-directed bone regeneration in the dog mandible: a comparison between biphasic calcium phosphate and natural bone mineral

Mesenchymal Stem Cell-Based Bone Engineering for Bone Regeneration

“…In another study, we have compared the bone regeneration capacity of HA/TCP/MSCs with Bio-Oss/MSC constructs. Our results have shown the enhanced bone regeneration potential of HA/TCP/MSCs construct in a canine full-thickness alveolar defect model (Jafarian et al, 2008) compared with Bio-Oss/MSCs constructs. Other research groups have studied the regenerative role of MSCs in combination with polymeric scaffolds in animal bone defects.…”

In vitro evaluation of the biological compatibility and antibacterial activity of a bone substitute material consisting of silver‐doped hydroxyapatite and Bio‐Oss®

“…So we must achieve a good balance between cell material interactions and antibacterial properties. According to the chemical formula Ca 10-x Ag x (-PO4) 6 (OH) 2-x and the results of ICP-OES, we could find that synthesized 0.5 AgHA included 1.4% Ag or so by weight, and therefore, the 1:1 mixture contained 0.7%, 1:2 contained 0.5% and 1:4 contained 0.3%. Some researchers have found that the 6.5% silver exhibited obvious toxicity in osteoblast cells, while 1% and 3% did not.…”

“…In this experiment, AgHA was synthesized via a chemical precipitation method. The amount of silver was determined based on x 5 0.5 in the chemical formula Ca 10 2 x Ag x (PO4) 6 (OH) 2-x . Mixing 0.5 AgHA with Bio-Oss V R at a ratio of 1:2 by weight is recommended because of this mixture's outstanding biological compatibility and effective antibacterial activity.…”

“…4 Some studies have reported that adding seeding, such as periodontal ligament stem cells (PDLSCs) or bone marrow mesenchymal stem cells (BMMSCs) onto Bio-Oss V R can promote bone formation and mineralization and maintain the maximum volume of the augmented maxillary sinus. 5,6 However , the result of GBR for peri-implantitis is in contradiction , During GBR, the local irrigation can't bring a lasting antimicrobial effect, which will lead to reattachment and regeneration of plaque. And this has a negative effect on bone regeneration, which may affect the prognosis of peri-implantitis.…”

Cranial bone defects: current and future strategies

“…95 As a BCP scaffold is resorbed in vivo, it releases calcium and phosphate ions into the microenvironment of the implant, and these ions can then be used to build bone de novo. 104 Although there have not been much published data on using BCP scaffolds to heal critical-size cranial defects, the scaffolds have been used to successfully aid in bone regeneration in mandibular defects in canines 48,105 and iliac wing defects in goats. 64 Additionally, a BCP scaffold (60% HA plus 40% b-TCP) seeded with rhBMP-2 was used to demonstrate complete spinal fusion in a nonhuman primate model.…”