Mesenchymal Stem Cell-Based Bone Engineering for Bone Regeneration

Eslaminejad, Mohamadreza Baghaban; Faghihi, Faezeh

doi:10.5772/21017

Cited by 6 publications

(1 citation statement)

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“…The mineralised matrix is formed by cells in the marrow called osteoblasts and resorbed by other cells, osteoclasts. Osteocytes are in contact with other cells on the bone surfaces, and respond to changes in physical forces, maintaining the bone's structure [41][42][43].…”

Section: Introductionmentioning

confidence: 99%

Extra low interstitial titanium based fully porous morphological bone scaffolds manufactured using selective laser melting

Bari

Arjunan

2019

Journal of the Mechanical Behavior of Biomedical Materials

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Lattice structure based morphologically matched scaffolds is rapidly growing facilitated by developments in Additive Manufacturing. These porous structures are particularly promising due to their potential in reducing stress shielding and maladapted stress concentration. Accordingly, this study presents Extra Low Interstitial (ELI) Titanium alloy based morphological scaffolds featuring three different porous architecture. All scaffolds were additively manufactured using Selective Laser Melting from Ti-6Al-4V ELI with porosities of 73.85, 60.53 and 55.26% with the global geometry dictated through X-Ray Computed Tomography.The elastic and plastic performance of both the scaffold prototypes and the bone section being replaced were evaluated through uniaxial compression testing.Comparing the data, the suitability of the Maxwell criterion in evaluating the stiffness behaviour of fully porous morphological scaffolds are carried out. The outcomes show that the best performing scaffolds presented in this study have high strength (169 MPa) and low stiffness (5.09 GPa) suitable to minimise stress shielding. The matching morphology in addition to high porosity allow adequate space for flow circulation and has the potential to reduce maladapted stress concentration. Finally, the Electron Diffraction X-ray analysis revealed a small difference in the composition of aluminium between the particle and the bonding material at the scaffold surface.

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Section: Introductionmentioning

confidence: 99%