Marrow adipose tissue spectrum in obesity and type 2 diabetes mellitus

Araújo, Iana Mizumukai de; Salmon, Carlos Ernesto Garrido; Nahas, Andressa Kutschenko; Nogueira-Barbosa, Marcello Henrique; Elías, Jorge; Paula, Francisco José Albuquerque de

doi:10.1530/eje-16-0448

Cited by 51 publications

(49 citation statements)

References 44 publications

(50 reference statements)

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“…However, MAT expansion is not observed in type 1 DM condition in humans (Slade et al , 2012). Likewise, some have reported that increased MAT is not a feature in obese type 2 DM subject (de Araujo et al , 2017). Yet, others have described a greater MAT content in lumbar spine and femoral metaphysis of morbid obese subjects with type 2 DM using insulin therapy or anti-diabetic oral agents (Yu et al , 2017).…”

Section: Osteoporosismentioning

confidence: 99%

“…Bone loss is one of the classical complications of type 1 DM patients (McCabe, 2007, Starup-Linde et al , 2016, Vestergaard, 2007). Conversely, type 2 DM patients usually have an adequate or increased BMD (Vestergaard, 2007, Starup-Linde et al , 2016, de Araujo et al , 2017). However, fracture risk is increased in both types of diabetes even though there are discrepancies in bone phenotype (Starup-Linde et al , 2016).…”

Section: Osteoporosismentioning

confidence: 99%

“…However, fracture risk is increased in both types of diabetes even though there are discrepancies in bone phenotype (Starup-Linde et al , 2016). Nutritional status is one factor that differs between types of diabetes: unlike type 1 DM, type 2 DM patients are overweight or obese with visceral fat accumulation (de Araujo et al , 2017). Higher body weight exerts a greater mechanical loading on the skeleton (Reid, 2010), and it can explain the absence of bone loss in these individuals.…”

Section: Osteoporosismentioning

confidence: 99%

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Energy Metabolism of Bone

et al. 2017

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Biological processes utilize energy and therefore must be prioritized based on fuel availability. Bone is no exception to this, and the benefit of remodeling when necessary outweighs the energy costs. Bone remodeling is important for maintaining blood calcium homeostasis, repairing micro cracks and fractures, and modifying bone structure so that it is better suited to withstand loading demands. Osteoclasts, osteoblasts and osteocytes are the primary cells responsible for bone remodeling, although bone marrow adipocytes and other cells may also play an indirect role. There is a renewed interest in bone cell energetics because of the potential for these processes to be targeted for osteoporosis therapies. In contrast, due to the intimate link between bone and energy homeostasis, pharmaceuticals that treat metabolic disease or have metabolic side effects often have deleterious bone consequences. In this brief review, we will introduce osteoporosis, discuss how bone cells utilize energy to function, evidence for bone regulating whole body energy homeostasis, and some of the unanswered questions and opportunities for further research in the field.

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Section: Osteoporosismentioning

confidence: 99%

Section: Osteoporosismentioning

confidence: 99%

Section: Osteoporosismentioning

confidence: 99%

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Energy Metabolism of Bone

et al. 2017

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“…For example, while WAT shrinks during starvation, MAT expands in number and size of BMAs, perhaps due to evolutionary adaptations to starvation [8]. While in certain cases (e.g., obesity and ovariectomy) WAT and BMAT correlate [9], and both can be reduced with exercise [10], no relationship between WAT and MAT was found in type 2 diabetic patients [11]. MAT also increases with age [12,13] and mesenchymal stem cells (MSCs) from older individuals (rodent and human) are more prone to adipogenic differentiation rather than osteogenic or chondrogenic differentiation [14,15].…”

Section: Bone Marrow Adipocytes Are Distinct From White Adipocytesmentioning

confidence: 99%

Reflections on Cancer in the Bone Marrow: Adverse Roles of Adipocytes

2017

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This review highlights the recent advances in our understanding of adipocyte contributions to carcinogenesis or cancer disease progression for cancers in the bone. Purpose In this review, we aim to describe bone marrow adipose tissue and discuss the soluble adipocyte-derived cytokines (adipokines) or endocrine factors, adipocyte-derived lipids, and the actual or putative juxtacrine signaling between bone marrow adipocytes and tumor cells in the bone marrow. This relationship likely affects tumor cell initiation, proliferation, metastasis, and/or drug resistance. Recent Findings Bone marrow adipose may affect tumor proliferation, drug resistance, or cancer-induced bone disease and hence may be a new target in the fight against cancer. Summary Overall, evidence is mixed regarding the role of bone marrow adipose and adipocytes in cancer progression, and more research in this arena is necessary to determine how these bone marrow microenvironmental cells contribute to malignancies in the marrow to identify novel, potentially targetable pathways.

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“…A justificativa sugerida é de que a redução drástica de tecido adiposo libera a vitamina D armazenada, permitindo a síntese do principal metabólito circulante da vitamina D (LESPESSAILLES;TOUMI, 2017;PEREIRA et al, 2007). (DE ARAÚJO et al, 2017;LIMA et al, 2016;DE PAULA et al, 2015;RUSSELL et al, 2010).…”

Section: Desenho Do Estudounclassified

Consequências da cirurgia bariátrica em curto (1 ano) e longo (5 anos) prazos sobre o tecido ósseo: inter-relações entre os tecidos ósseo e adiposo

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Federal do Maranhão (UFMA) e aos seus pilares-Prof. Dr. Manuel dos Santos Faria e Prof. Dra. Maria Honorina Cordeiro Lopes-, exemplos de mestres, com inspiração que transforma. Ao ambulatório de Cirurgia Bariátrica do HC-FMRP-USP, ao coordenador, Dr. Wilson Salgado Junior, e, em especial, aos pacientes que participaram com várias idas ao Hospital de Clínicas-a maioria deles era de cidades vizinhas e até mesmo de outros estados. Ao Laboratório de Osteometabolismo do HC-FMRP-USP e aos técnicos e colegas pósgraduandos que participaram ativamente da pesquisa e do meu aprendizado. Em especial às amigas Luciana Parreiras, Iana Mizumukai e Marta Nakao. À família Schittini-Dr. Newton, Dra. Lucilene, Isabele, Fernando e Felipe-, que sempre apoiou a minha família.

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Marrow adipose tissue spectrum in obesity and type 2 diabetes mellitus

Abstract: MAT is not a niche for fat accumulation under conditions of energy surplus and type 2 diabetes, also is not associated with VAT or insulin resistance. MAT is associated with glycated hemoglobin.

Cited by 51 publications

References 44 publications

Energy Metabolism of Bone

Energy Metabolism of Bone

Reflections on Cancer in the Bone Marrow: Adverse Roles of Adipocytes

Consequências da cirurgia bariátrica em curto (1 ano) e longo (5 anos) prazos sobre o tecido ósseo: inter-relações entre os tecidos ósseo e adiposo

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