Marker chromosome 14q+ in non-endemic Burkitt's lymphoma

Abstract

The chromosomal aberrations in tumor cells obtained by bone marrow aspiration from a patient with non-endemic Burkitt's lymphoma (BL) are reported. Twenty percent of the cells contained the marker chromosome 14q+ earlier described in endemic Burkitt's tumors. Other marker chromosomes were dound only in mitoses which did not contain the 14q+.

Genesis of the 14q+ marker in Burkitt's lymphoma

“…14 having at the end of its long arm an additional band, positive in Q-and G-banding. This finding has been confirmed by a number of authors (PETIT et al 1972;JARVIS et al 1974;ZECH et al 1976;KAISER-MCCAW et al 1976PHILIP et al 1977;TEMPLE le77). Markers more or less similar to the original marl4q+ have also been demonstrated in other types of lymphoid neoplasia (REEVES 1973;MARK 1975;PHILIP 1975;PRIGOGINA and FLEISCHMAN 1975;FLEISCHMAN and PRK;OGINA 1977;LUNG and ROWLEY 1978).…”

Morphology of lymphatic cells and of their derived tumours.

“…Outside Africa, Burkitt type ALL has been reported to represent 2 % of all ALL . In African (Manolov and Manolova, 1972) and non-African (Hubner and Littlefield, 1975;Philip et al, 1977) Burkitt ML, structural chromosomal abnormalities were found. The existence of ML in which a variable proportion of the neoplastic cells show mature or immature plasmacytic or plasmacytoid features is fully recognised.…”

14q+ marker chromosome in an EBV‐genome‐negative lymph node without signs of malignancy in a patient with EBV‐genome‐positive nasopharyngeal carcinoma

“…The 14q+ marker chromosome, first desc:ibed by Manolov and Manolova (1972) has been confirmed as a characteristic and consistent finding in Burkitt's lymphoma (BL) (references in Mitelman and Levan, 1978). The marker has been found in all of the tumor biopsies studied not only from Africa but also from the USA (Kaiser-McCaw et al, 1977) and Europe (Philip et al, 1977). Zech el al.…”