Marine spongin incorporation into Biosilicate® for tissue engineering applications: An in vivo study

Parisi, Júlia Risso; Fernandes, Kelly Rossetti; Vale, Giovanna Caroline Aparecida do; Santana, Alan de França; Cruz, Matheus de Almeida; Fortulan, Carlos Alberto; Zanotto, Edgar Dutra; Peitl, Oscar; Granito, Renata Neves; Rennó, Ana Cláudia Muniz

doi:10.1177/0885328220922161

Cited by 14 publications

(9 citation statements)

References 41 publications

(89 reference statements)

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“…The stretching vibrations of the N–H and CO groups of amide I (mainly the stretching vibrations of CO) and amide II (stretching of C–H and bending of N–H) cause relatively intense bands at 1630 cm −1 and 1520 cm −1 [ 38 , 39 , 40 ]. Furthermore, the amide III band extending from 1220 to 1300 cm −1 , which can be seen in the case of the spongin samples, is due to the phase combination of carbon–nitrogen bond stretching as well as N–H plane bending vibrations, considerably reducing the peptide bond (–CONH–) footprint in the spectrum of the organic/inorganic material [ 41 , 42 ]. Finally, the N–H band can be observed at 472 cm − 1 ( Figure 4 a), partially overlapping with the Fe–O band at 563 cm −1 ( Figure 4 b), leading to the lower wavenumbers of the N–H band at 461 cm −1 [ 15 , 26 ].…”

Section: Resultsmentioning

confidence: 99%

Adsorption of Cationic Dyes on a Magnetic 3D Spongin Scaffold with Nano-Sized Fe3O4 Cores

et al. 2021

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The renewable, proteinaceous, marine biopolymer spongin is yet the focus of modern research. The preparation of a magnetic three-dimensional (3D) spongin scaffold with nano-sized Fe3O4 cores is reported here for the first time. The formation of this magnetic spongin–Fe3O4 composite was characterized by X-ray diffraction (XRD), thermogravimetric analysis (TGA), differential thermal analysis (DTA) (TGA-DTA), vibrating sample magnetometer (VSM), Fourier-transform infrared spectroscopy (FTIR), and zeta potential analyses. Field emission scanning electron microscopy (FE-SEM) confirmed the formation of well-dispersed spherical nanoparticles tightly bound to the spongin scaffold. The magnetic spongin–Fe3O4 composite showed significant removal efficiency for two cationic dyes (i.e., crystal violet (CV) and methylene blue (MB)). Adsorption experiments revealed that the prepared material is a fast, high-capacity (77 mg/g), yet selective adsorbent for MB. This behavior was attributed to the creation of strong electrostatic interactions between the spongin–Fe3O4 and MB or CV, which was reflected by adsorption mechanism evaluations. The adsorption of MB and CV was found to be a function of pH, with maximum removal performance being observed over a wide pH range (pH = 5.5–11). In this work, we combined Fe3O4 nanoparticles and spongin scaffold properties into one unique composite, named magnetic spongin scaffold, in our attempt to create a sustainable absorbent for organic wastewater treatment. The appropriative mechanism of adsorption of the cationic dyes on a magnetic 3D spongin scaffold is proposed. Removal of organic dyes and other contaminants is essential to ensure healthy water and prevent various diseases. On the other hand, in many cases, dyes are used as models to demonstrate the adsorption properties of nanostructures. Due to the good absorption properties of magnetic spongin, it can be proposed as a green and uncomplicated adsorbent for the removal of different organic contaminants and, furthermore, as a carrier in drug delivery applications.

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Section: Resultsmentioning

confidence: 99%

Adsorption of Cationic Dyes on a Magnetic 3D Spongin Scaffold with Nano-Sized Fe3O4 Cores

et al. 2021

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“…Biomaterials with different compositions and structure have been extensively studied for bone tissue engineering proposals. In this context, a composite material, including BS enriched with a newly marine Col was studied (Parisi et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Association of marine Collagen/Biosilicate composites and photobiomodulation in the process of bone healing using an experimental model of calvarial defect

Vale

Fernandes

Parisi

et al. 2021

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The study comparing the bone regenerative capacity in an experimental model of cranial bone defects in rats, into 3 groups: G1: bone defects irradiated with photobiomodulation; G2: Biosilicate + photobiomodulation and G3: Biosilicate and Spongin + photobiomodulation. Histocompatibility and bone responses were performed after 15 and 45 days of implantation. Histological analysis demonstrated that photobiomodulation irradiated animals presented an increased amount of newly formed over time. Histomorphometry showed higher values for bone volume for G3 and G1, higher values for osteoid volume and number of osteoblasts observed for G3 compared to G2. TGF-β immunolabelling was higher for G2. The values found for VEGF were higher for biosilicate (with or without spongin) 15 days of implantation with an increased difference being observed for G1, 45 days after surgery. In conclusion, the stimulus provided by photobiomodulation associated to the biomimetic composite increased bone formation in the cranial bone defect in rats. Consequently, these data highlight the potential of the introduction of spongin into biosilicate and irradiated with photobiomodulation to improve the biological performance for bone regeneration applications.

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“…A series of experiments revealed a positive effect of sponge collagen hydrolysates on damaged or photoaged skin [270]. In addition, a recent in vivo study using rats demonstrated biocompatibility and the ability to support bone formation of biocomposites generated from collagen, isolated from A. fulva, and biosilicate [271]. Finally, powdered collagenous sponge scaffold loaded with L-cysteine hydrochlorid proved to cause a positive effect on wound healing [272].…”

Section: Marine Invertebrates Collagenmentioning

confidence: 97%

“…Furthermore, this structural protein is used for controlled drug release including antimicrobial agents such as tetracycline [270]. In another research, a potential of anticancer drug(s) loaded 3D printed patches from fish gelatin for anticancer treatment was demonstrated [271]. Due to its excellent absorption properties and the ability to resorb up to 56 days, fish collagen can be used to control wound blood bleeding [272].…”

Section: Marine Vertebrates Collagenmentioning

confidence: 99%

Progress in Modern Marine Biomaterials Research

et al. 2020

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The growing demand for new, sophisticated, multifunctional materials has brought natural structural composites into focus, since they underwent a substantial optimization during long evolutionary selection pressure and adaptation processes. Marine biological materials are the most important sources of both inspiration for biomimetics and of raw materials for practical applications in technology and biomedicine. The use of marine natural products as multifunctional biomaterials is currently undergoing a renaissance in the modern materials science. The diversity of marine biomaterials, their forms and fields of application are highlighted in this review. We will discuss the challenges, solutions, and future directions of modern marine biomaterialogy using a thorough analysis of scientific sources over the past ten years.

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Marine spongin incorporation into Biosilicate® for tissue engineering applications: An in vivo study

Cited by 14 publications

References 41 publications

Adsorption of Cationic Dyes on a Magnetic 3D Spongin Scaffold with Nano-Sized Fe3O4 Cores

Adsorption of Cationic Dyes on a Magnetic 3D Spongin Scaffold with Nano-Sized Fe3O4 Cores

Association of marine Collagen/Biosilicate composites and photobiomodulation in the process of bone healing using an experimental model of calvarial defect

Progress in Modern Marine Biomaterials Research

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