Progress in Modern Marine Biomaterials Research

Khrunyk, Yuliya; Lach, Sławomir; Petrenko, Iaroslav; Ehrlich, Hermann

doi:10.3390/md18120589

Cited by 77 publications

(63 citation statements)

References 394 publications

(443 reference statements)

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“…They may have novel physical, chemical/stereochemical as well as original biochemical properties (Trincone, 2011). Although there are wide possibilities for use of marine based products for the development of bioinspired materials in medicine (such as replacement heart valves, bone implants or hips and joints, Khrunyk et al, 2020), there are still several challenges that must be solved. For instance, the isolation and purification of the biopolymers play an important role in targeted drug delivery and control of the sustained drug release concentrations.…”

Section: Bio-inspired Materialsmentioning

confidence: 99%

The Essentials of Marine Biotechnology

Barbier²,

et al. 2021

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Coastal countries have traditionally relied on the existing marine resources (e.g., fishing, food, transport, recreation, and tourism) as well as tried to support new economic endeavors (ocean energy, desalination for water supply, and seabed mining). Modern societies and lifestyle resulted in an increased demand for dietary diversity, better health and well-being, new biomedicines, natural cosmeceuticals, environmental conservation, and sustainable energy sources. These societal needs stimulated the interest of researchers on the diverse and underexplored marine environments as promising and sustainable sources of biomolecules and biomass, and they are addressed by the emerging field of marine (blue) biotechnology. Blue biotechnology provides opportunities for a wide range of initiatives of commercial interest for the pharmaceutical, biomedical, cosmetic, nutraceutical, food, feed, agricultural, and related industries. This article synthesizes the essence, opportunities, responsibilities, and challenges encountered in marine biotechnology and outlines the attainment and valorization of directly derived or bio-inspired products from marine organisms. First, the concept of bioeconomy is introduced. Then, the diversity of marine bioresources including an overview of the most prominent marine organisms and their potential for biotechnological uses are described. This is followed by introducing methodologies for exploration of these resources and the main use case scenarios in energy, food and feed, agronomy, bioremediation and climate change, cosmeceuticals, bio-inspired materials, healthcare, and well-being sectors. The key aspects in the fields of legislation and funding are provided, with the emphasis on the importance of communication and stakeholder engagement at all levels of biotechnology development. Finally, vital overarching concepts, such as the quadruple helix and Responsible Research and Innovation principle are highlighted as important to follow within the marine biotechnology field. The authors of this review are collaborating under the European Commission-funded Cooperation in Science and Technology (COST) Action Ocean4Biotech – European transdisciplinary networking platform for marine biotechnology and focus the study on the European state of affairs.

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Section: Bio-inspired Materialsmentioning

confidence: 99%

The Essentials of Marine Biotechnology

Barbier²,

et al. 2021

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“…At present, studies have isolated natural products with anti-tumor, anti-microbiol, and other biological activities from marine organisms [ 12 , 13 , 14 , 16 , 17 , 25 ]. Modern pharmacological research also shows that many marine biological metabolites are effective in killing phytopathogenic microbes and can be used for the development of biological microbicides.…”

Section: Active Substances Derived From Different Marine Sourcesmentioning

confidence: 99%

“…However, after a long period of screening in recent years, the terrestrial biological resources are extremely reduced, and people pay more attention to the marine organisms, which account for 71% of the earth’s biological resources. Marine biological resources are extremely rich, and the special marine environment makes it possible for marine organisms to produce different natural active substances from terrestrial organisms [ 12 , 13 , 14 ]. The structures and pharmacological effects of these marine-derived active substances are usually unmatched by those derived from the terrestrial organisms.…”

Section: Introductionmentioning

confidence: 99%

Screening of Marine Bioactive Antimicrobial Compounds for Plant Pathogens

Zhao

Chen

2021

Marine Drugs

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Plant diseases have been threatening food production. Controlling plant pathogens has become an important strategy to ensure food security. Although chemical control is an effective disease control strategy, its application is limited by many problems, such as environmental impact and pathogen resistance. In order to overcome these problems, it is necessary to develop more chemical reagents with new functional mechanisms. Due to their special living environment, marine organisms have produced a variety of bioactive compounds with novel structures, which have the potential to develop new fungicides. In the past two decades, screening marine bioactive compounds to inhibit plant pathogens has been a hot topic. In this review, we summarize the screening methods of marine active substances from plant pathogens, the identification of marine active substances from different sources, and the structure and antibacterial mechanism of marine active natural products. Finally, the application prospect of marine bioactive substances in plant disease control was prospected.

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“…Followed by the production from bovine hides and accounts for 29.4%, and bovine bones and accounts for 23.1% [ 2 ]. Gelatin can be derived from various marine species (Fish species, sponges, jellyfish, squid, and snails [ 17 ]. Currently, the production from fish accounts for only 1.5 % [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Cosmetic, Biomedical and Pharmaceutical Applications of Fish Gelatin/Hydrolysates

et al. 2021

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There are several reviews that separately cover different aspects of fish gelatin including its preparation, characteristics, modifications, and applications. Its packaging application in food industry is extensively covered but other applications are not covered or covered alongside with those of collagen. This review is comprehensive, specific to fish gelatin/hydrolysate and cites recent research. It covers cosmetic applications, intrinsic activities, and biomedical applications in wound dressing and wound healing, gene therapy, tissue engineering, implants, and bone substitutes. It also covers its pharmaceutical applications including manufacturing of capsules, coating of microparticles/oils, coating of tablets, stabilization of emulsions and drug delivery (microspheres, nanospheres, scaffolds, microneedles, and hydrogels). The main outcomes are that fish gelatin is immunologically safe, protects from the possibility of transmission of bovine spongiform encephalopathy and foot and mouth diseases, has an economic and environmental benefits, and may be suitable for those that practice religious-based food restrictions, i.e., people of Muslim, Jewish and Hindu faiths. It has unique rheological properties, making it more suitable for certain applications than mammalian gelatins. It can be easily modified to enhance its mechanical properties. However, extensive research is still needed to characterize gelatin hydrolysates, elucidate the Structure Activity Relationship (SAR), and formulate them into dosage forms. Additionally, expansion into cosmetic applications and drug delivery is needed.

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Progress in Modern Marine Biomaterials Research

Cited by 77 publications

References 394 publications

The Essentials of Marine Biotechnology

The Essentials of Marine Biotechnology

Screening of Marine Bioactive Antimicrobial Compounds for Plant Pathogens

Cosmetic, Biomedical and Pharmaceutical Applications of Fish Gelatin/Hydrolysates

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