Marine Origin Collagens and Its Potential Applications

Silva, Tiago H.; Moreira‐Silva, Joana; Marques, Ana Paula; Domingues, Ana Verónica; Bayon, Yves; Reis, Rui L.

doi:10.3390/md12125881

Cited by 319 publications

(290 citation statements)

References 103 publications

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“…These values correspond only to the acidic extraction and may indicate that collagen from Codfish skins is more resilient to this extraction and that it may be necessary to use further enzymatic extraction [36]. Furthermore, these values are in accordance with those observed in other studies with the same species or others [36,37].…”

Section: Collagen Extraction: Salmon and Codfish Skinssupporting

confidence: 79%

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Cosmetic Potential of Marine Fish Skin Collagen

et al. 2017

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Many cosmetic formulations have collagen as a major component because of its significant benefits as a natural humectant and moisturizer. This industry is constantly looking for innovative, sustainable, and truly efficacious products, so marine collagen based formulations are arising as promising alternatives. A solid description and characterization of this protein is fundamental to guarantee the highest quality of each batch. In the present study, we present an extensive characterization of marine-derived collagen extracted from salmon and codfish skins, targeting its inclusion as component in cosmetic formulations. Chemical and physical characterizations were performed using several techniques such as sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE), Fourier Transformation Infrared (FTIR) spectroscopy rheology, circular dichroism, X-ray diffraction, humidity uptake, and a biological assessment of the extracts regarding their irritant potential. The results showed an isolation of type I collagen with high purity but with some structural and chemical differences between sources. Collagen demonstrated a good capacity to retain water, thus being suitable for dermal applications as a moisturizer. A topical exposure of collagen in a human reconstructed dermis, as well as the analysis of molecular markers for irritation and inflammation, exhibited no irritant potential. Thus, the isolation of collagen from fish skins for inclusion in dermocosmetic applications may constitute a sustainable and low-cost platform for the biotechnological valorization of fish by-products.

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Section: Collagen Extraction: Salmon and Codfish Skinssupporting

confidence: 79%

“…A slightly shift in the position of the α and β chains can be observed between the species. This may be probably due to differences in the amino acid composition that lead to slight alterations in the molecular weight [37]. …”

Section: Sds-page Analysismentioning

confidence: 99%

Cosmetic Potential of Marine Fish Skin Collagen

et al. 2017

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“…19,20 It is possible to use fish discards to isolate collagen, which is further used in various biomedical fields, such as in wound dressing. 21 However, effective wound dressings should have suitable tensile strength, a certain degree of antibacterial activity, as well as the ability to promote skin regeneration early. Therefore, in this study, fish collagen and BG were used to fabricate multifunctional and inexpensive electrospun fish Col/BG composite nanofibers.…”

Section: Resultsmentioning

confidence: 99%

Multifunctional and biomimetic fish collagen/bioactive glass nanofibers: fabrication, antibacterial activity and inducing skin regeneration in vitro and in vivo

Zhou¹,

Sui²,

Mo³

et al. 2017

IJN

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The development of skin wound dressings with excellent properties has always been an important challenge in the field of biomedicine. In this study, biomimetic electrospun fish collagen/bioactive glass (Col/BG) nanofibers were prepared. Their structure, tensile strength, antibacterial activity and biological effects on human keratinocytes, human dermal fibroblasts and human vascular endothelial cells were investigated. Furthermore, the Sprague Dawley rat skin defect model was used to validate their effect on wound healing. The results showed that compared with pure fish collagen nanofibers, the tensile strength of the Col/BG nanofibers increased to 21.87±0.21 Mpa, with a certain degree of antibacterial activity against Staphylococcus aureus . It was also found that the Col/BG nanofibers promoted the adhesion, proliferation and migration of human keratinocytes. Col/BG nanofibers induced the secretion of type one collagen and vascular endothelial growth factor by human dermal fibroblasts, which further stimulated the proliferation of human vascular endothelial cells. Animal experimentation indicated that the Col/BG nanofibers could accelerate rat skin wound healing. This study developed a type of multifunctional and biomimetic fish Col/BG nanofibers, which had the ability to induce skin regeneration with adequate tensile strength and antibacterial activity. The Col/BG nanofibers are also easily available and inexpensive, providing the possibility for using as a functional skin wound dressing.

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“…As the extraction of biomedical material from mammalian tissue is always accompanied by concerns about the safety of the material, new sources have received attention in recent years. These include poultry as well as marine sources of collagen like fish, shark, jellyfish and marine sponges [18]. However, the production of collagen from these sources is still limited.…”

Section: Introductionmentioning

confidence: 99%

Hydrogels based on collagen and fibrin – frontiers and applications

Schneider-Barthold¹,

Baganz²,

Wilhelmi

et al. 2016

BioNanoMaterials

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Hydrogels are a versatile tool for a multitude of applications in biomedical research and clinical practice. Especially collagen and fibrin hydrogels are distinguished by their excellent biocompatibility, natural capacity for cell adhesion and low immunogenicity. In many ways, collagen and fibrin represent an ideal biomaterial, as they can serve as a scaffold for tissue regeneration and promote the migration of cells, as well as the ingrowth of tissues. On the other hand, pure collagen and fibrin materials are marked by poor mechanical properties and rapid degradation, which limits their use in practice. This paper will review methods of modification of natural collagen and fibrin materials to next-generation materials with enhanced stability. A special focus is placed on biomedical products from fibrin and collagen already on the market. In addition, recent research on the in vivo applications of collagen and fibrin-based materials will be showcased.

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Marine Origin Collagens and Its Potential Applications

Cited by 319 publications

References 103 publications

Cosmetic Potential of Marine Fish Skin Collagen

Cosmetic Potential of Marine Fish Skin Collagen

Multifunctional and biomimetic fish collagen/bioactive glass nanofibers: fabrication, antibacterial activity and inducing skin regeneration in vitro and in vivo

Hydrogels based on collagen and fibrin – frontiers and applications

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