Multifunctional and biomimetic fish collagen/bioactive glass nanofibers: fabrication, antibacterial activity and inducing skin regeneration in vitro and in vivo

Zhou, Tian; Sui, Baiyan; Mo, Xiumei; Sun, Jiao

doi:10.2147/ijn.s132459

Cited by 94 publications

(79 citation statements)

References 31 publications

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“…Tilapia collagen/bioactive glass (Col/BG) nanofibers, fabricated via electrospinning, were used as wound dressing to protect against infection and to promote wound healing and skin regrowth in both in vivo and in vitro studies [120].…”

Section: Fish Wastementioning

confidence: 99%

Marine Collagen from Alternative and Sustainable Sources: Extraction, Processing and Applications

et al. 2020

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Due to its unique properties, collagen is used in the growing fields of pharmaceutical and biomedical devices, as well as in the fields of nutraceuticals, cosmeceuticals, food and beverages. Collagen also represents a valid resource for bioplastics and biomaterials, to be used in the emerging health sectors. Recently, marine organisms have been considered as promising sources of collagen, because they do not harbor transmissible disease. In particular, fish biomass as well as by-catch organisms, such as undersized fish, jellyfish, sharks, starfish, and sponges, possess a very high collagen content. The use of discarded and underused biomass could contribute to the development of a sustainable process for collagen extraction, with a significantly reduced environmental impact. This addresses the European zero-waste strategy, which supports all three generally accepted goals of sustainability: sustainable economic well-being, environmental protection, and social well-being. A zero-waste strategy would use far fewer new raw materials and send no waste materials to landfills. In this review, we present an overview of the studies carried out on collagen obtained from by-catch organisms and fish wastes. Additionally, we discuss novel technologies based on thermoplastic processes that could be applied, likewise, as marine collagen treatment.2 of 23 protective colloid functions and film-forming capacity. Also, collagen is a good surface-active agent, with its ability to penetrate lipid-free interfaces [2].Collagen can be utilized in a variety of applications because of its biocompatibility and excellent degradability [3,4]. Furthermore, it is known that collagen is a molecule with weak immunogenicity, which decreases the possibilities of rejection when it is ingested or injected into a different body. Although this molecule has already low antigenicity, this property can be enhanced by modifying it to suppress any immune response [5,6]. Additionally, collagen peptides and gelatin (denatured collagen) have been widely utilized in different fields such as food, medicine, cosmetics, leather and film industries, diagnostic imaging, and therapeutic delivery [7].For many years, most available collagen was extracted from discards from the bovine and porcine processing industries, but during the last few decades the use of collagen from these sources has been limited. The use of porcine and bovine-derived products is occasionally prevented by dietary regimes, due to specific needs or personal choices. It is forbidden by religious constraints, to Muslims, Hindus and Jews who make up 38.4% of the global population [8]. Moreover, the use of bovine-derived products became a concern for a wider section of the population during the bovine spongiform encephalopathy (BSE), transmissible spongiform encephalopathy (TSE) and foot-and-mouth disease (FMD) crises that occurred over the last few decades in all areas of the world, mostly in the United Kingdom and Asia. Bovine-derived products might be a vehicle of transmission of these diseases ...

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Section: Fish Wastementioning

confidence: 99%

Marine Collagen from Alternative and Sustainable Sources: Extraction, Processing and Applications

et al. 2020

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“…The main appeal of electrospinning, aside from the simplicity of the equipment required, is the tunability of the method, allowing the generation of fibers from as small as tens of nanometers to several micrometers with a wide array of morphologies. In biomedical applications, recent work has utilized electrospun polycaprolactone/gelatin composite materials for guided bone regeneration, drug delivery in soft tissue, and wound dressings based on biodegradable polymers such as polyetherimide, polylactic acid, and others . In electrochemistry, electrospun materials are being employed in a range of devices, such as lithium‐ion battery separators .…”

Section: Introductionmentioning

confidence: 99%

Insights into the Effect of Structural Heterogeneity in Carbonized Electrospun Fibrous Mats for Flow Battery Electrodes by X‐Ray Tomography

Kok

Jervis

Brett

et al. 2018

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Electrospun custom made flow battery electrodes are imaged in 3D using X-ray computed tomography. A variety of computational methods and simulations are applied to the images to determine properties including the porosity, fiber size, and pore size distributions as well as the material permeability and flow distributions. The simulations are performed on materials before and after carbonization to determine the effect it has in the internal microstructure and material properties. It is found that the deposited fiber size is constantly changing throughout the electrospinning process. The results also show that the surfaces of the fibrous material are the most severely altered during carbonization and that the rest of the material remained intact. Pressure driven flow is modeled using the lattice Boltzmann method and excellent agreement with experimental results is found. The simulations coupled with the material analysis also demonstrate the highly heterogeneous nature of the flow. Most of the flow is concentrated to regions with high porosity while regions with low porosity shield other pores and starve them of flow. The importance of imaging these materials in 3D is highlighted throughout.

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“…Nanofiber electrospun from tilapia skin collagen promoted the proliferation of human HaCaT keratinocytes, and stimulated epidermal differentiation through the up-regulated gene expression of involucrin, filaggrin, and type I transglutaminase in these cells. Moreover, the tilapia collagen nanofibers accelerated wound healing in vivo in rat models [91][92][93][94]. Beneficial effects on wound healing were also observed in nanofibrous meshes electrospun from collagen obtained from Arothron stellatus [96] and from fish scale collagen peptides [90].…”

Section: Nature-derived Nanofibers Degradable In the Human Tissuesmentioning

confidence: 88%

“…In addition, the fish collagen enables an easier recovery of intact collagen triple helices than the mammalian collagen [92]. Fish collagen can be obtained from the skin, scales and bones of freshwater fish, such as tilapia [91][92][93][94], and marine fish, such as hoki fish (Macruronus novaezelandiae) [92,95], or Arothron stellatus, also known as "stellate puffer," "starry puffer" or "starry toadfish" [96]. Nanofiber electrospun from tilapia skin collagen promoted the proliferation of human HaCaT keratinocytes, and stimulated epidermal differentiation through the up-regulated gene expression of involucrin, filaggrin, and type I transglutaminase in these cells.…”

Section: Nature-derived Nanofibers Degradable In the Human Tissuesmentioning

confidence: 99%

“…Collagen was also grafted on the surface of composite electrospun PVA/gelatin/alginate nanofibers [41]. Collagen-based or collagen-containing nanofibers have been loaded with a wide range of bioactive substances, such as vitamin C, vitamin D3, hydrocortisone, insulin, triiodothyronine, and epidermal growth factor [100], transforming growth factor-β1 [102], plant extracts such as Coccinia grandis leaf extract [96], or lithospermi radix extract [107], antibiotics such as gentamicin [103], or bioactive glass [93,104]. Collagen and PCL and bioactive glass nanoparticles were applied for delivery of endothelial progenitor cells into wounds in order to promote their vascularization and healing [104].…”

Section: Nature-derived Nanofibers Degradable In the Human Tissuesmentioning

confidence: 99%

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Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Nature-Derived Polymers

Bačáková¹,

Pajorová²,

Zikmundová³

et al. 2020

Current and Future Aspects of Nanomedicine

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Nanofibrous scaffolds belong to the most suitable materials for tissue engineering, because they mimic the fibrous component of the natural extracellular matrix. This chapter is focused on the application of nanofibers in skin tissue engineering and wound healing, because the skin is the largest and vitally important organ in the human body. Nanofibrous meshes can serve as substrates for adhesion, growth and differentiation of skin and stem cells, and also as an antimicrobial and moistureretaining barrier. These meshes have been prepared from a wide range of synthetic and nature-derived polymers. This chapter is focused on the use of nature-derived polymers. These polymers have good or limited degradability in the human tissues, which depends on their origin and on the presence of appropriate enzymes in the human tissues. Non-degradable and less-degradable polymers are usually produced in bacteria, fungi, algae, plants or insects, and include, for example, cellulose, dextran, pullulan, alginate, pectin and silk fibroin. Well-degradable polymers are usually components of the extracellular matrix in the human body or at least in other verte brates, and include collagen, elastin, keratin and hyaluronic acid, although some polymers produced by non-vertebrate organisms, such as chitosan or poly(3-hydroxybutyrate-co-3-hydroxyvalerate), are also degradable in the human body.Current and Future Aspects of Nanomedicine 2 microbial infection, and at the same time, they can keep appropriate moisture and gas exchange at the wound site.Nanofibrous scaffolds for skin tissue engineering have been fabricated from a wide range of synthetic and nature-derived polymers, which can be either biostable or degradable within the human body. Biostable synthetic polymers used in nanofiber-based skin regenerative therapies include, for example, polyurethane [2], polydimethylsiloxane [3], polyethylene terephthalate [4], polyethersulfone [5], and also hydrogels such as poly(acrylic acid) (PAA, [6]), poly(methyl methacrylate) (PMMA, [7]), and poly[di(ethylene glycol) methyl ether methacrylate] (PDEGMA, [8]). Degradable synthetic polymers typically include poly(ε-caprolactone) (PCL, [9]) and its copolymers with polylactides (PLCL, [10]), polylactides (PLA, [11]) and their copolymers with polyglycolides (PLGA, [12]), and also so-called auxiliary polymers, such as poly(ethylene glycol) (PEG), poly(ethylene oxide) (PEO, [13]) or poly(vinyl alcohol) (PVA, [14]), which facilitated the electrospinning process and improved the mechanical properties and wettability of the chief polymer. However, the synthetic polymers, although they are well-chemically defined and tailorable, are often bioinert, hydrophobic and thus not promoting cell adhesion, and also not well-adhering to the wound site. Therefore, they need to be combined with other bioactive substances, particularly nature-derived polymers.This chapter is focused on nature-derived polymers used for fabrication of nanofibrous scaffolds for skin tissue engineering and wound healing. The advantages of...

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Multifunctional and biomimetic fish collagen/bioactive glass nanofibers: fabrication, antibacterial activity and inducing skin regeneration in vitro and in vivo

Cited by 94 publications

References 31 publications

Marine Collagen from Alternative and Sustainable Sources: Extraction, Processing and Applications

Marine Collagen from Alternative and Sustainable Sources: Extraction, Processing and Applications

Insights into the Effect of Structural Heterogeneity in Carbonized Electrospun Fibrous Mats for Flow Battery Electrodes by X‐Ray Tomography

Nanofibrous Scaffolds for Skin Tissue Engineering and Wound Healing Based on Nature-Derived Polymers

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