Marine Omega3 wound matrix for the treatment of complicated wounds

Abstract

Summary Introduction Complicated wounds in the lower extremity can arise as a consequence of insufficient soft-tissue coverage after amputations in diabetic patients. The Kerecis® Omega3 wound matrix is a decellularized skin matrix derived from codfish and represents an alternative treatment option to achieve wound healing. Methods 5 patients with diabetes mellitus and complicated wounds in the lower limb with exposed bony segments were treated with the Omega3 wound matrix between November 2014 and November 2015. Following initial debridement in the operating room, the wound matrix was applied and covered with a silicone mesh. In the further course, wound treatment was conducted on outpatient setting. Results In total, 7 wounds were treated with localization at the level of the thigh (n=2) and the forefoot (n=5). For the wounds at the thigh, it took 26 weeks to achieve wound closure, whereas the wounds at the level of the forefoot showed healing times between 13 and 41 weeks. In all patients, a reduction of analgetics intake was noted when the treatment with the Omega3 wound matrix was initiated. Conclusion The Kerecis® Omega3 wound matrix represents a viable treatment option in complicated wounds in the lower limb of diabetic patients to circumvent an otherwise necessary proximalization of amputation level. Further studies comparing the Omega3 wound matrix with appropriate control groups of standard therapies for soft-tissue conditioning/coverage like negative pressure therapy, biosurgery and other acellular dermal matrices are warranted.

A rare case report of neonatal calcinosis cutis induced by distant and delayed extravasation of intravenous calcium gluconate

“…Also, in fish skin graft, there is additional benefits of omega-3 lipids. Omega-3 fatty acids help wound healing with anti-inflammatory effect and are resistant to bacterial colonization [ 18 , 19 ]. With combination of extracellular matrix component and omega-3 lipids, the Kerecis provide nutrient wound environment for epithelization.…”

Impact of the chronic wound microenvironment and marine omega‐3 fatty acids on skin cell regeneration processes

“…In clinical practice, commercial products containing ω3 FA, such as acellular fish skin matrices, showed significant advantages in the treatment of chronic wounds compared to matrices of murine, porcine and human origin. 10,32 Fibroblasts and keratinocytes effectively proliferate and migrate along the three-dimensional matrix structure. However, considering the presented results of EPA and DHA in the migration assay, ω3 FAs do not seem to be the primary beneficial driver on skin cells in the regenerative and reparative process.…”

Acellular Fish Skin Grafts and Pig Urinary Bladder Matrix Assessed in the Collagen-Induced Arthritis Mouse Model

“…No adverse reactions have been observed during clinical use of the fish skin grafts. [26][27][28] Healthy volunteers with fullthickness skin wounds that were treated with the fish skin grafts showed no elevations of anti-type I collagen or antitype II collagen antibodies. 29 The detection of anti-type II collagen antibodies in the porcine collagen group was unexpected.…”