Marine macroalga Caulerpa: role of its metabolites in modulating cancer signaling

Mehra, Richa; Bast, Felix; Singh, Sandeep

doi:10.1007/s11033-019-04743-5

Cited by 22 publications

(25 citation statements)

References 92 publications

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“…[152], one of them being cytotoxic [240]. Chromodoris mandapamensis from India contains spongiadiol (74) (Figure 9), which is also present in Glossodoris cincta (cited as G. atromarginata) from Egypt, and was previously isolated from Australian sponges, within a mixture of related spongiane compounds [170]. C. mandapamensis was found on an unidentified sponge also containing spongiadiol, and thus supporting its dietary origin.…”

Section: Tetracyclic Diterpenoidsmentioning

confidence: 80%

“…caulerpenyne has also been reported [70]. Caulerpenyne is a highly bioactive molecule, presenting anticancer activity, cell grown inhibition, neurotoxic activity, and inhibiting lipoxygenases, among others [71][72][73][74]. Some shelled sacoglossans are also rich in monoterpenoids, which they can obtain from their algal food and further transform into more bioactive compounds.…”

Section: Linear Monoterpenoidsmentioning

confidence: 99%

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Terpenoids in Marine Heterobranch Molluscs

Ávila

2020

Marine Drugs

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Heterobranch molluscs are rich in natural products. As other marine organisms, these gastropods are still quite unexplored, but they provide a stunning arsenal of compounds with interesting activities. Among their natural products, terpenoids are particularly abundant and diverse, including monoterpenoids, sesquiterpenoids, diterpenoids, sesterterpenoids, triterpenoids, tetraterpenoids, and steroids. This review evaluates the different kinds of terpenoids found in heterobranchs and reports on their bioactivity. It includes more than 330 metabolites isolated from ca. 70 species of heterobranchs. The monoterpenoids reported may be linear or monocyclic, while sesquiterpenoids may include linear, monocyclic, bicyclic, or tricyclic molecules. Diterpenoids in heterobranchs may include linear, monocyclic, bicyclic, tricyclic, or tetracyclic compounds. Sesterterpenoids, instead, are linear, bicyclic, or tetracyclic. Triterpenoids, tetraterpenoids, and steroids are not as abundant as the previously mentioned types. Within heterobranch molluscs, no terpenoids have been described in this period in tylodinoideans, cephalaspideans, or pteropods, and most terpenoids have been found in nudibranchs, anaspideans, and sacoglossans, with very few compounds in pleurobranchoideans and pulmonates. Monoterpenoids are present mostly in anaspidea, and less abundant in sacoglossa. Nudibranchs are especially rich in sesquiterpenes, which are also present in anaspidea, and in less numbers in sacoglossa and pulmonata. Diterpenoids are also very abundant in nudibranchs, present also in anaspidea, and scarce in pleurobranchoidea, sacoglossa, and pulmonata. Sesterterpenoids are only found in nudibranchia, while triterpenoids, carotenoids, and steroids are only reported for nudibranchia, pleurobranchoidea, and anaspidea. Many of these compounds are obtained from their diet, while others are biotransformed, or de novo biosynthesized by the molluscs. Overall, a huge variety of structures is found, indicating that chemodiversity correlates to the amazing biodiversity of this fascinating group of molluscs.

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Section: Tetracyclic Diterpenoidsmentioning

confidence: 80%

Section: Linear Monoterpenoidsmentioning

confidence: 99%

Terpenoids in Marine Heterobranch Molluscs

Ávila

2020

Marine Drugs

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“…PTP1B inhibitor alkaloids also have well-described biological activity, as reported in studies bioprospecting marine natural products with anti-tumor activity [123]. However, some studies have also demonstrated the participation of PTP1B as a regulator of proinflammatory signaling pathways.…”

Section: Bioprospecting Of Marine Anti-inflammatory Alkaloids and Futmentioning

confidence: 92%

Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives

2020

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Alkaloids are nitrogenous compounds with various biological activities. Alkaloids with anti-inflammatory activity are commonly found in terrestrial plants, but there are few records of the identification and characterization of the activity of these compounds in marine organisms such as fungi, bacteria, sponges, ascidians, and cnidarians. Seaweed are a source of several already elucidated bioactive compounds, but few studies have described and characterized the activity of seaweed alkaloids with anti-inflammatory properties. In this review, we have gathered the current knowledge about marine alkaloids with anti-inflammatory activity and suggest future perspectives for the study and bioprospecting of these compounds.

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“…Many of these compounds have special biological activities and chemical structures that can be used as potential medicines for many diseases [6,7]. Most of these marine plants extracts have been confirmed to be anti-cancer [8,9], anti-inflammatory [10,11], anti-viral [12,13], etc. Marine medicines derived from marine plant extracts have received more and more attention.…”

Section: Introductionmentioning

confidence: 99%

Exploration in the mechanism of fucosterol for the treatment of non-small cell lung cancer Based on network pharmacology and molecular docking

Lin

et al. 2020

Preprint

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Background: It has been demonstrated that fucosterol induces a therapeutic effect on cancer. However, the molecular mechanisms underlying the effects of fucosterol in the treatment of non-small cell lung cancer are still unclear.Methods: In this study, pharmMapper and GeneCards databases were utilized to gather the prediction of fucosterol targets and NSCLC-related targets. The mechanisms of fucosterol against NSCLC were identified in DAVID6.8 by enrichment analysis of GO and KEGG, and protein-protein interaction data was obtained from Sting Database. Molecular docking was used to predict the docking of GRB2. Moreover, the relationship of GRB2 expression and immune infiltrates was analyzed by TIMER database.Results: The results suggest that fucosterol acts against by candidate targets, such as MAPK1, EGFR, GRB2, IGF2, MAPK8 and SRC, which regulate biological processes including negative regulation of apoptotic process, peptidyl-tyrosine phosphorylation, positive regulation of cell proliferation. The Raf / MEK / ERK signaling pathway initiated by GRB2 maybe the most significant pathway for fucosterol to treat NSCLC.Conclusions: These results show that GRB2 is the key target for fucosterol in the treatment of NSCLC, which laying a theoretical foundation for further research and providing scientific support for the development of new drugs.

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Marine macroalga Caulerpa: role of its metabolites in modulating cancer signaling

Cited by 22 publications

References 92 publications

Terpenoids in Marine Heterobranch Molluscs

Terpenoids in Marine Heterobranch Molluscs

Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives

Exploration in the mechanism of fucosterol for the treatment of non-small cell lung cancer Based on network pharmacology and molecular docking

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