Exploration in the mechanism of fucosterol  for the treatment of  non-small cell lung cancer Based on network pharmacology and molecular docking

Abstract

Background: It has been demonstrated that fucosterol induces a therapeutic effect on cancer. However, the molecular mechanisms underlying the effects of fucosterol in the treatment of non-small cell lung cancer are still unclear.Methods: In this study, pharmMapper and GeneCards databases were utilized to gather the prediction of fucosterol targets and NSCLC-related targets. The mechanisms of fucosterol against NSCLC were identified in DAVID6.8 by enrichment analysis of GO and KEGG, and protein-protein interaction data was obtained from Sting Database. Molecular docking was used to predict the docking of GRB2. Moreover, the relationship of GRB2 expression and immune infiltrates was analyzed by TIMER database.Results: The results suggest that fucosterol acts against by candidate targets, such as MAPK1, EGFR, GRB2, IGF2, MAPK8 and SRC, which regulate biological processes including negative regulation of apoptotic process, peptidyl-tyrosine phosphorylation, positive regulation of cell proliferation. The Raf / MEK / ERK signaling pathway initiated by GRB2 maybe the most significant pathway for fucosterol to treat NSCLC.Conclusions: These results show that GRB2 is the key target for fucosterol in the treatment of NSCLC, which laying a theoretical foundation for further research and providing scientific support for the development of new drugs.

Equivalência De Grupos Com Variáveis Latentes: Uma Aplicação De Modelagem De Equações Estruturais Na Avaliação Da Influência Do Gênero Na Satisfação Do Cliente Em Comunicações Móveis

“…Como a literatura sugeriu que o fucosterol (1) pode apresentar atividade anticâncer (JIANG et al, 2018;MAO et al, 2019;LI et al, 2021). Os compostos 1-5 foram submetidos a uma triagem preliminar sobre linhagens de celulares tumorais humanas, incluindo MCF-7 (carcinoma de mama), HL-60 (leucemia promielocítica) e HCT-116 (câncer colorretal).…”

Proyecto De Apoyo Para Equipos De Medición De Vibraciones Vibrec 500

“…Como a literatura sugeriu que o fucosterol (1) pode apresentar atividade anticâncer (JIANG et al, 2018;MAO et al, 2019;LI et al, 2021). Os compostos 1-5…”

The pharmacokinetic characteristics and excretion studies of fucosterol from Sargasssum fusiforme in rats

“…The last three account for >95% of phytosterol dietary intake (from terrestrial high plants) and are known to have cholesterol‐lowering effects and reduce the risk of cardiovascular disease (Kaur & Myrie, 2020; Moreau et al, 2018). Fucosterol can reduce cholesterol absorption (Ikeda et al, 1988), in addition to exhibiting anticancer (Bae et al, 2020; Li et al, 2021), hepatoprotection (Moreau et al, 2018), neuroprotection (Hannan et al, 2019; Oh et al, 2018) and other biological effects (Abdul et al, 2016; Perumal et al, 2018).…”