Marine Food Protection in Testicular Damages Caused by Diabetes Mellitus

Caiaffo, Vitor; Oliveira, Belisa Duarte Ribeiro de; Sa, Fabricio Bezerra de; Neto, Joaqvim Evencio; Silva, Voldemiro Amaro da

doi:10.2174/1573399812666160618123229

Cited by 5 publications

(3 citation statements)

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“…DM can result in many systemic complications, such as complication in the heart, kidneys, peripheral nerves and reproductive system [5, 9]. DM has been associated with negative effects on the male sexual function in humans and animal models including reduced spermatogenesis, erectile dysfunction, ejaculation disorder, sexual behavior and endocrine system abnormalities [1, 6, 8, 13]. It is also associated with the overproduction of reactive oxygen species (ROS) and decreased efficiency of antioxidant defenses [12].…”

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confidence: 99%

Effects of <i>Vernonia cinerea</i> on reproductive performance in streptozotocin-induced diabetic rats

Pomjunya

Ratthanophart²,

Fungfuang

2017

The Journal of Veterinary Medical Science

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The present study investigated the effects of Vernonia cinerea (VC) on the reproductive function in streptozotocin (STZ)-induced diabetic male rats. Six-week-old male Sprague-Dawley rats were randomly divided into four groups: group 1, normal control rats; group 2, diabetic untreated rats; group 3, diabetic rats treated with VC (10 mg/kg); and group 4, diabetic rats treated with VC (40 mg/kg). Diabetes mellitus (DM) was induced by intraperitoneal injection of STZ (60 mg/kg). All animals were treated for 30 consecutive days. Body weight, blood glucose, food intake, epididymal sperm parameters, testicular microstructure and serum testosterone levels were evaluated. VC treatment significantly restored the sperm motility and testosterone concentration, and decreased the testicular histopathological changes in DM rats. Moreover, high-dose VC exhibited an antidibetic activity and significantly improved the sperm count. In conclusion, we found, for the first time, that administration of VC significantly restored the testicular function and testosterone concentration in diabetic male rats.

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confidence: 99%

Effects of <i>Vernonia cinerea</i> on reproductive performance in streptozotocin-induced diabetic rats

Pomjunya

Ratthanophart²,

Fungfuang

2017

The Journal of Veterinary Medical Science

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“…

Male infertility caused by diabetes occurs in an alarming number of cases (Caiaffo et al, 2017). Testicular damage is the primary aetiology and is difficult to reverse (Maresch et al, 2018).

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confidence: 99%

Cordycepin, a major bioactive component ofCordyceps militaris, ameliorates diabetes‐induced testicular damage through the Sirt1/Foxo3a pathway

Huang

Zhou

et al. 2021

Andrologia

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Diabetes‐induced male dysfunction is considered as a worldwide challenge, and testicular damage mainly caused by oxidative stress is its most common manifestation. Cordycepin, a natural antioxidant, has been used in the treatment of diabetic complications. However, the protective action and underlying mechanism of cordycepin on hyperglycaemia‐induced testicular damage are unclear. This study aimed to investigate the protective effects and molecular mechanisms of cordycepin against diabetes‐induced testicular damage. The type 2 diabetes model was established in C57BL/6 male mice via high‐fat diet for 4 weeks and injected intraperitoneally with 50 mg/kg/day streptozotocin for five consecutive days. Then mice were treated with cordycepin (10 and 20 mg/kg, respectively) for 8 weeks. At the end of experiment, biochemical indicators, microstructure of testicular tissue, sperm morphology, TUNEL staining and protein expressions were evaluated. In the present study, cordycepin alleviated the testicular damage, restored disruption of the blood‐testis barrier, and improved spermatogenic function via the antiapoptotic and antioxidant capacity. Mechanistically, cordycepin significantly enhanced SIRT1 expression and triggered the activity of Foxo3a, further to induce the expression of its downstream antioxidant enzymes, including Mn‐SOD and CAT. These findings indicated that cordycepin could improve hyperglycaemia‐induced testicular damage by regulating downstream antioxidant enzymes activity through the SIRT1/Foxo3a signalling pathway.

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“…Endocrine disorders: DM was shown to promote apoptosis in testicular cells by affecting Bcl-2 and caspase protease expression, leading to decreased testosterone levels, structural changes in smooth muscle cell, which also contributed to the development of ED ( 38 , 39 ).Improving the understanding of the molecular mechanisms underlying the development of DMED could contribute to the development of more effective treatments.…”

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confidence: 99%

Current status and prospects of diabetes mellitus induced erectile dysfunction: A bibliometric and visualization study

et al. 2023

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BackgroundThe prevalence of diabetes mellitus-induced erectile dysfunction (DMED) has recently increased, which has prompted numerous DMED studies. Here, we conduct a bibliometric analysis of relevant literature in the field of DMED and to discuss the research hotspots and future development directions.MethodsThe Web of Science Core Collection database was searched for literature on DMED, and literature characterization including the number of articles, journals, countries/regions, institutions, authors, keywords, and other information was performed using VOS viewer and CiteSpace software. In addition, Pajek software was used for visual map adjustment, and GraphPad Prism was used to generate line graphs.ResultsA total of 804 articles concerning DMED were included in this study. The Journal of Sexual Medicine issued the most documents(92 articles). The United States and China were in the leading position in the field of DMED research, and cross-institutional collaboration on DMED research worldwide needs to be further strengthened. Ryu JK were the authors with the highest number of documents issued (22 articles) while Bivalacqua TJ was the author with the most co-citated(249 co-citated). The keywords analysis shows that the main research hotspots in the field of DMED were mechanism discussions and disease treatment and management.ConclusionsGlobal research on DMED is expected to increase further. The investigation of the mechanism of DMED and the exploration of new therapeutic means and targets are the focus of future research.

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Marine Food Protection in Testicular Damages Caused by Diabetes Mellitus

Abstract: The seafood plays an antioxidant, anti-inflammatory and anti-apoptosis role in testicles morphology damages induced by diabetes mellitus. This relation seems to be associated with Omega-3 and carotenoids (astaxanthin) levels.

Cited by 5 publications

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Effects of <i>Vernonia cinerea</i> on reproductive performance in streptozotocin-induced diabetic rats

Effects of <i>Vernonia cinerea</i> on reproductive performance in streptozotocin-induced diabetic rats

Cordycepin, a major bioactive component ofCordyceps militaris, ameliorates diabetes‐induced testicular damage through the Sirt1/Foxo3a pathway

Current status and prospects of diabetes mellitus induced erectile dysfunction: A bibliometric and visualization study

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