Mannan binding lectin and viral hepatitis

Brown, Kristelle; Ryder, Stephen; Irving, William L.; Sim, Robert B.; Hickling, Timothy P.

doi:10.1016/j.imlet.2006.10.006

Cited by 59 publications

(48 citation statements)

References 94 publications

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“…The association of MBL with viral hepatitis has been investigated by several authors (26,27); the interactions between HCV envelope glycoproteins E1 and E2 and MBL has been demonstrated in vitro and mutant MBL2 haplotypes have been linked to disease progression in HCV infection (26). However, the relationship between L-ficolin and viral hepatitis remains elusive.…”

Section: Introductionmentioning

confidence: 99%

Specifically Binding of L-ficolin to N-glycans of HCV Envelope Glycoproteins E1 and E2 Leads to Complement Activation

Liu

Ali

et al. 2009

Cell Mol Immunol

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L-ficolin, one of lectin families, is a recently identified complement factor that initiates lectin pathway of complement. Little is known about its role in viral hepatitis. In the present study, we found that L-ficolin in serum from 103 patients with hepatitis C virus (HCV), were significantly higher than that in 150 healthy controls. We further found that L-ficolin expressions were significantly increased in vitro study by HCV JFH-1 infected human hepatocyte cell line Huh7.5.

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Section: Introductionmentioning

confidence: 99%

Specifically Binding of L-ficolin to N-glycans of HCV Envelope Glycoproteins E1 and E2 Leads to Complement Activation

Liu

Ali

et al. 2009

Cell Mol Immunol

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“…MBL is a lectin specific for mannose and N-acetylglucosamine that recognizes a wide range of pathogens, including bacteria, yeasts, mycobacteria, fungi, and viruses, and facilitates the uptake of glycoproteins with terminal mannose residues by phagocytic cells bearing lectin receptors (3). The middle surface protein of the HBV envelope contains a mannose-rich oligosaccharide to which MBL can bind (3).…”

Section: Discussionmentioning

confidence: 99%

“…The majority of studies revealed a correlation between MBL polymorphisms that confer low levels of MBL and poor prognoses such as viral persistence (9), disease progression (4,5,10), HBV acquisition (4) and survival in case of fulminant hepatic failure (6). However, some studies did not show any correlation between MBL polymorphisms and the prognosis of HBV infection (11) (as reviewed by Brown et al [3]). Previous studies revealed that the mutation of codon 54 (allele B) was linked with lower serum MBL levels (5,8), and that a lower serum MBL level was associated with poor prognosis of HBV infection (5,8), while a high serum MBL level was correlated with survival of patients with fulminant hepatic failure caused by HBV infection (6).…”

Section: Discussionmentioning

confidence: 99%

“…The innate immune system may therefore be very important for the prevention of HBV infection (3). Mannose-binding lectin (MBL) is a plasma collectin that is synthesized in the liver and secreted into the bloodstream.…”

Section: Introductionmentioning

confidence: 99%

“…Mannose-binding lectin (MBL) is a plasma collectin that is synthesized in the liver and secreted into the bloodstream. It acts as a pattern recognition molecule of the innate immune system that binds to sugars on the surface of invading microorganisms and plays a central role in the innate immune response (3). A decrease in the MBL level has been observed in acute (4) and chronic (5) HBV infections, whereas an increase in the MBL level has been shown to be positively associated with survival in case of fulminant hepatic failure (6).…”

Section: Introductionmentioning

confidence: 99%

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Potential Role of Mannose-Binding Lectin in Intrauterine Transmission of Hepatitis B Virus

Zhou

Wang

et al. 2013

Jpn J Infect Dis

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SUMMARY: Intrauterine transmission of hepatitis B virus (HBV) is the main cause of the high prevalence of HBV in endemic areas; however, the mechanisms underlying intrauterine transmission of HBV remain unknown. To explore the role of mannose-binding lectin (MBL), a pattern recognition molecule of the innate immune system, in intrauterine transmission of HBV, we determined MBL levels using an enzyme-linked immunosorbent assay (ELISA) in cord serum of 7 intrauterine-infected neonates and 30 non-infected neonates born to HBV-positive mothers, and 30 control neonates born to HBV-negative mothers. We observed significant differences in cord serum MBL levels among the three groups ( P º 0.001). Non-infected neonates had significantly higher MBL levels than controls (P º 0.001), and intrauterine-infected neonates had significantly lower serum MBL levels than non-infected neonates ( P º 0.001). However, serum MBL levels were not significantly different between intrauterine-infected neonates and controls ( P ＝ 0.800). Our results indicate that maternal HBV infection induces an increase in fetal MBL levels and the absence of this increase is possibly associated with intrauterine transmission of HBV, suggesting that MBL plays a role in intrauterine transmission of HBV.

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Single nucleotide polymorphisms rs2120131, rs4935047, and rs7095891 in the MBL2 gene show no association with susceptibility to chronic hepatitis B in a Chinese Han population

Zhang

Liu

et al. 2013

Journal of Medical Virology

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Thus far, many studies have evaluated the correlation between MBL2 gene polymorphisms and hepatitis B infection. Tag single nucleotide polymorphisms (SNPs) were used to investigate the relationship between MBL2 gene polymorphisms and susceptibility to chronic hepatitis B virus (HBV) infection by comparing 996 chronic HBV infection cases to 301 acute infection controls. There was no significant correlation between rs2120131, rs4935047, and rs7095891 and chronic HBV infection. This suggested that the new SNPs within MBL2 were not associated with susceptibility to chronic hepatitis B in a Chinese Han population.

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Mannan binding lectin and viral hepatitis

Cited by 59 publications

References 94 publications

Specifically Binding of L-ficolin to N-glycans of HCV Envelope Glycoproteins E1 and E2 Leads to Complement Activation

Specifically Binding of L-ficolin to N-glycans of HCV Envelope Glycoproteins E1 and E2 Leads to Complement Activation

Potential Role of Mannose-Binding Lectin in Intrauterine Transmission of Hepatitis B Virus

Single nucleotide polymorphisms rs2120131, rs4935047, and rs7095891 in the MBL2 gene show no association with susceptibility to chronic hepatitis B in a Chinese Han population

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