A relationship between chronic hepatitis C virus (HCV) infection and interleukin-10 (IL-10) gene polymorphisms has been reported with controversial results in different studies. In an effort to solve this controversy, we quantitatively summarized ten studies on this relationship by means of meta-analysis. Our analysis included ten case-control studies with 992 cases of chronic HCV infection and 1,123 controls. Analyses were performed with STATA version 9.0. The results showed that the IL-10 -1082GG genotype significantly increased the risk for persistent HCV infection (AA vs. GG: OR = 0.680, 95% CI = 0.489-0.947, P = 0.022; AG vs. GG: OR = 0.608, 95% CI = 0.439-0.840, P = 0.003; GG vs. AG + AA: OR = 1.570, 95% CI = 1.160-2.123, P = 0.003), but no statistically significant differences were observed between cases and controls for IL-10 -819C/T and IL-10 -592C/A polymorphisms (P > 0.05). In conclusion, this meta-analysis suggested that the IL-10 -1082GG genotype was associated with increased susceptibility for chronic HCV infection.

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The data demonstrated that PD-1.1 and PD-1.2 polymorphisms are not associated with chronic HBV infection in Chinese patients.

Thus far, many studies have evaluated the correlation between MBL2 gene polymorphisms and hepatitis B infection. Tag single nucleotide polymorphisms (SNPs) were used to investigate the relationship between MBL2 gene polymorphisms and susceptibility to chronic hepatitis B virus (HBV) infection by comparing 996 chronic HBV infection cases to 301 acute infection controls. There was no significant correlation between rs2120131, rs4935047, and rs7095891 and chronic HBV infection. This suggested that the new SNPs within MBL2 were not associated with susceptibility to chronic hepatitis B in a Chinese Han population.