Polymorphisms in programmed death-1 gene are not associated with chronic HBV infection in Chinese patients

Lin, Feng; Gao, Yufeng; Zhang, Zhen-Huan; Zhang, Tian-Chen; Pan, Faming; Cui, Ming-fang; Xia, Shu-Ling; Xu, Li; Yin, Hua-fa

doi:10.4254/wjh.v3.i3.72

Cited by 4 publications

(3 citation statements)

References 34 publications

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“…However a study in China disagreed with our results, reported that PD1 gene polymorphism has no correlation with genetic susceptibility to HBV infection in Chinese patients 6 .…”

Section: Discussioncontrasting

confidence: 99%

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Polymorphism of programmed death-1 (PD-1) gene in relation to susceptibility and progression of hepatitis B virus infection in Egyptian patients

Awad

Gazzar²,

Allam³

et al. 2020

Egyptian Journal of Medical Microbiology

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Background: chronic infection with hepatitis B virus (HBV) is a major risk factor for liver cirrhosis and hepatocellular carcinoma (HCC). Programmed death-1 (PD-1) has been involved in regulating immune responses to viral infections and tumors and has a critical role in HBV infection. Objectives: to investigate the effect of PD1 (+8669 G/A) single-nucleotide polymorphism (SNP) on disease susceptibility and progression of chronic HBV infection in Egyptian patients. Methodology: Blood samples were taken from 70 patients with confirmed chronic hepatitis B (CHB), HBV-related liver cirrhosis (LC) or HCC on top of HBV infection and 25 healthy controls. Genotyping of PD1 (+8669 G/A) polymorphism was studied using bidirectional PCR amplification of specific alleles (Bi-PASA).Results: A significantly higher frequency of PD-1 (+8669 G/A) AA genotype and A allele was found in CHB group (36.8 %) and LC group (21.7%) compared to control group (0.0%) (P< 0.05). On the other hand, the GG genotype and G allele were over represented in healthy controls (72.7%) than CHB group (52.6%) and LC group (47.8%). In assessing the risk of susceptibility to infection with HBV, The G allele was significantly predominant in healthy subjects compared to hepatitis B patients (89.4% versus 68.5%) (P< 0.05). G allele was markedly increased with disease progression to HCC (P = 0.006). Conclusion: Our study suggested that PD1 (+8669) polymorphism has significantly implicated in the disease susceptibility with AA genotype and A allele as a predisposing and the GG genotype and G allele as a preventive factors for chronic HBV infection. Also this study revealed a significant effect of the PD1 (+8669) polymorphism in the progression to HCC in hepatitis B patients.

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“…However a study in China disagreed with our results, reported that PD1 gene polymorphism has no correlation with genetic susceptibility to HBV infection in Chinese patients 6 .…”

Section: Discussioncontrasting

confidence: 99%

“…PD-1, an inhibitory modulator of T cell activity, is playing a crucial role in the regulation of immune responses against viral infections and tumors 6 . PD-1 is expressed on T-cells, B-cells and myeloid cells as an inhibitory immunereceptor.…”

Section: Introductionmentioning

confidence: 99%

Polymorphism of programmed death-1 (PD-1) gene in relation to susceptibility and progression of hepatitis B virus infection in Egyptian patients

Awad

Gazzar²,

Allam³

et al. 2020

Egyptian Journal of Medical Microbiology

View full text Add to dashboard Cite

show abstract

“…Programmed cell death-1 ( PD-1 ), a member of the CD28/B7 superfamily of costimulatory molecules, is expressed on activated CD4+ and CD8+ T cells, natural killer T (NKT) cells, B cells, activated monocytes and some dendritic cell (DC) [ 1 ]. The human gene encoding PD-1 is located on chromosome 2q37.3, which encodes a 50–55 kD type I transmembranous glycoprotein protein [ 2 , 3 ]. The PD-1 is consisted of an immunoglobulin-like extracellular domain, and a cytoplasmic domain containing an immunoreceptor tyrosine-based inhibitory motif (ITIM) and immunoreceptor tyrosine-based switch motif (ITSM) [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Programmed Cell Death-1 Polymorphisms Decrease the Cancer Risk: A Meta-Analysis Involving Twelve Case-Control Studies

et al. 2016

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Programmed cell death-1 (PD-1) plays an important inhibitory role in anti-tumor responses, so it is considered as a powerful candidate gene for individual’s genetic susceptibility to cancer. Recently, some epidemiological studies have evaluated the association between PD-1 polymorphisms and cancer risk. However, the results of the studies are conflicting. Therefore, a meta-analysis was performed. We identified all studies reporting the relationship between PD-1 polymorphisms and cancers by electronically searches. According to the inclusion criteria and the quality assessment of Newcastle-Ottawa Scale (NOS), only high quality studies were included. A total of twelve relevant studies involving 5,206 cases and 5,174 controls were recruited. For PD-1.5 (rs2227981) polymorphism, significantly decreased cancer risks were obtained among overall population, Asians subgroup and population-based subgroup both in TT vs. CC and TT vs. CT+CC genetic models. In addition, a similar result was also found in T vs. C allele for overall population. However, there were no significant associations between either PD-1.9 (rs2227982) or PD-1 rs7421861 polymorphisms and cancer risks in all genetic models and alleles. For PD-1.3 (rs11568821) polymorphism, we found different cancer susceptibilities between GA vs. GG and AA vs. AG+GG genetic models, and no associations between AA vs. GG, AA+AG vs. GG genetic models or A vs. G allele and cancer risks. In general, our results firstly indicated that PD-1.5 (rs2227981) polymorphism is associated a strongly decreased risk of cancers. Additional epidemiological studies are needed to confirm our findings.

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Association of programmed death-1 polymorphisms with the risk and prognosis of esophageal squamous cell carcinoma

Zhou

Wang

et al. 2016

Cancer Genetics

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Polymorphisms in programmed death-1 gene are not associated with chronic HBV infection in Chinese patients

Abstract: The data demonstrated that PD-1.1 and PD-1.2 polymorphisms are not associated with chronic HBV infection in Chinese patients.

Cited by 4 publications

References 34 publications

Polymorphism of programmed death-1 (PD-1) gene in relation to susceptibility and progression of hepatitis B virus infection in Egyptian patients

Polymorphism of programmed death-1 (PD-1) gene in relation to susceptibility and progression of hepatitis B virus infection in Egyptian patients

Programmed Cell Death-1 Polymorphisms Decrease the Cancer Risk: A Meta-Analysis Involving Twelve Case-Control Studies

Association of programmed death-1 polymorphisms with the risk and prognosis of esophageal squamous cell carcinoma

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