Mangosteen extract reduce apoptosis via inhibition of oxidative process in rat model of traumatic brain injury

Indharty, Rr Suzy; Japardi, Iskandar; Siahaan, Andre Mp; Tandean, Steven

doi:10.15562/bmj.v8i1.1153

Cited by 4 publications

(6 citation statements)

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“…Formulating optimal delivery systems, conducting robust clinical trials, and considering combination therapies are critical for advancing alpha-mangostin-based antiviral therapies. Additionally, the integration of pharmacogenomic approaches and sustainable production practices will enhance its therapeutic potential and support its responsible utilization [50][51][52].…”

Section: Sustainability and Commercial Productionmentioning

confidence: 99%

Untitled

2024

J. Med. Chem. Sci.

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This mini review aims to explore the potential of alpha-mangostin as an antiviral candidate. Alpha-mangostin is a natural compound found in the fruit of the Garcinia mangostana tree. Over the years, it has attracted considerable attention due to its diverse pharmacological properties, including antiviral activity. This review provides an overview of the current literature on the antiviral effects of alpha-mangostin, focusing on its mechanisms of action and its efficacy against various viral infections. The potential application of alpha-mangostin as a therapeutic agent against viral diseases is discussed, along with future research directions and challenges in the development of alpha-mangostin-based antiviral therapies.

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Section: Sustainability and Commercial Productionmentioning

confidence: 99%

Untitled

2024

J. Med. Chem. Sci.

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“…In brief, the pharmacological activities of mangosteen and its bioactive compounds demonstrate their potential in various health conditions. From their antioxidant and anti-inflammatory effects to their anticancer, antimicrobial, and neuroprotective properties, mangosteen exhibits a wide range of pharmacological activities that warrant further exploration and clinical research for their therapeutic applications [17][18][19][20][21][22][23][24][25][26][27].…”

Section: Pharmacological Activities Of Garcinia Mangostana Lmentioning

confidence: 99%

Natural Products Isolated from Various Parts of Mangosteen (Garcinia mangostana L.) as Therapeutic Agent: A Review

Ansori,

Antonius,

Murtadlo

et al. 2023

Advances in Biological Sciences Research

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T his review provides a comprehensive analysis of the therapeutic potential of natural products derived from mangosteen ( Garcinia mangostana L.). Mangosteen, a tropical fruit native to Southeast Asia, has long been valued for its medicinal properties. The review focuses on the isolation and characterization of bioactive compounds from different parts of the plant, including the fruit, rind, and leaves. The bioactive compounds identified in mangosteen exhibit a diverse range of therapeutic activities, making them promising candidates for the development of various therapeutic agents. These compounds include xanthones, flavonoids, tannins, and phenolic acids, among others. Xanthones, in particular, have shown potent antioxidant, anti-inflammatory, anticancer, antimicrobial, and neuroprotective properties. Additionally, they have been reported to have beneficial effects on various chronic diseases such as cardiovascular disorders, diabetes, and obesity. This review highlights the mechanisms of action underlying the therapeutic effects of mangosteen-derived compounds.

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“…A total of eight studies tested mangosteen antioxidant activity in an animal model related to a neurological disorder. Among these, two studies used Alzheimer's model (Avinash et al, 2016;Huang et al, 2014), while others used Parkinson's model (Parkhe et al, 2020), depression model (Oberholzer et al, 2018), memory impairment model (Sattayasai et al, 2013), cognitive impairment model (Phyu and Tangpong, 2014), schizophrenia immune-inflammatory model (Lotter et al, 2020), and closed head injury model (Indharty et al, 2019). There are two neurological disorders that commonly occur in elderly patients, i.e., Alzheimer's and Parkinson's.…”

Section: Mangosteen Antioxidant Activity In Neurological Disordermentioning

confidence: 99%

“…In a closed head injury model, the injury was carried out using Feeney's weight-drop procedure by dropping a metal mass on the opened scalp on the right frontal area of a rat (Indharty et al, 2019). It was explained that traumatic brain injury causes two kinds of damage, which are the initial damage due to the physical force and the secondary damage that occurs hours or days after the initial damage due to neuroinflammatory response and oxidative stress.…”

Section: Mangosteen Antioxidant Activity In Neurological Disordermentioning

confidence: 99%

“…It was explained that traumatic brain injury causes two kinds of damage, which are the initial damage due to the physical force and the secondary damage that occurs hours or days after the initial damage due to neuroinflammatory response and oxidative stress. Results showed that mangosteen pericarp ethanolic extract improved traumatic brain injury subjects by significantly increasing the SOD antioxidant level and reducing neuronal apoptosis based on the downregulation of apoptosis-inducing factor (AIF), caspase-8, caspase-9, and MDA level (Indharty et al, 2019).…”

Section: Mangosteen Antioxidant Activity In Neurological Disordermentioning

confidence: 99%

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