Manganese Inhibits Viability of Prostate Cancer Cells

Hernroth, Bodil; Holm, Ingvar; Gondikas, Andreas; Tassidis, Helena

doi:10.21873/anticanres.12201

Cited by 9 publications

(3 citation statements)

References 26 publications

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“…This could be because the greater amount of Mn in this material provides easier access to the Mn 2+ ions in the carbonate structure with the one-pot synthetic method. Another possibility is that treatment induces apoptosis in tumoral cells, coinciding with a previous study in prostate cancer cells where Mn reduces cell viability and promotes the G0/G1 phase in these cells [ 26 ].…”

Section: Discussionsupporting

confidence: 64%

New Carbonate-Based Materials and Study of Cytotoxic Capacity in Cancer Cells

Niza-Pérez

Quiroz‐Troncoso

Alegría‐Aravena

et al. 2023

IJMS

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Calcium carbonate, one of the most commonly found biominerals produced by organisms, has shown great potential for the development of systems with biological applications due to its excellent biocompatibility, biodegradability, and simple chemical composition. Here, we focus on the synthesis of various carbonate-based materials with vaterite phase control and their subsequent functionalization for applications in treating glioblastoma, one of the most limiting tumors currently without effective treatments. The incorporation of l-cysteine into the systems increased cell selectivity while the incorporation of manganese supplied the materials with cytotoxic capacity. Extensive characterization of the systems by infrared spectroscopy, ultraviolet-visible spectroscopy, X-ray diffraction, X-ray fluorescence, and transmission electron microscopy confirmed the incorporation of the different fragments causing selectivity and cytotoxicity to the systems. To verify their therapeutic activity, the vaterite-based materials were tested in the CT2A cell line (murine glioma) and compared to SKBR3 (breast cancer) and HEK-293T (human kidney) cell lines. These studies on the cytotoxicity of the materials have shown promising results that can encourage future in vivo studies in glioblastoma models.

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Section: Discussionsupporting

confidence: 64%

New Carbonate-Based Materials and Study of Cytotoxic Capacity in Cancer Cells

Niza-Pérez

Quiroz‐Troncoso

Alegría‐Aravena

et al. 2023

IJMS

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“…Smf1 is a member of the natural resistance-associated macrophage protein (NRAMP) family of transporters which includes the human counterparts DMT1 [ 63 ] and NRAMP1 [ 64 ] transporters. As NRAMP1 polymorphism has been associated with some types of cancer [ 65 , 66 ], it would be worthwhile studying the oleandrin action on these type of cancer in correlation with Mn 2+ homeostasis, considering that Mn 2+ alone was found to inhibit the viability of cancer cells [ 67 , 68 ].…”

Section: Discussionmentioning

confidence: 99%

Cytotoxicity of Oleandrin Is Mediated by Calcium Influx and by Increased Manganese Uptake in Saccharomyces cerevisiae Cells

2020

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Oleandrin, the main component of Nerium oleander L. extracts, is a cardiotoxic glycoside with multiple pharmacological implications, having potential anti-tumoral and antiviral characteristics. Although it is accepted that the main mechanism of oleandrin action is the inhibition of Na+/K+-ATPases and subsequent increase in cell calcium, many aspects which determine oleandrin cytotoxicity remain elusive. In this study, we used the model Saccharomyces cerevisiae to unravel new elements accounting for oleandrin toxicity. Using cells expressing the Ca2+-sensitive photoprotein aequorin, we found that oleandrin exposure resulted in Ca2+ influx into the cytosol and that failing to pump Ca2+ from the cytosol to the vacuole increased oleandrin toxicity. We also found that oleandrin exposure induced Mn2+ accumulation by yeast cells via the plasma membrane Smf1 and that mutants with defects in Mn2+ homeostasis are oleandrin-hypersensitive. Our data suggest that combining oleandrin with agents which alter Ca2+ or Mn2+ uptake may be a way of controlling oleandrin toxicity.

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“…Half-maximal cytotoxic concentration (in mM) of various cationic species: Li [428,429,430], Na [431,432,433,434], Mg [435,436,437,438], Sr [439,440,441], Al [442,443,444], Ga [408,445], Sn [406,446,447], Te [448,449,450], Pb [427,451], Bi [452,453,454,455], Ti [406,408,443,444,456,457], V [408,442,443,444], Cr [408,442,443,444], Mn [443,458,459,460], Fe [426,442,443,461], Co [406,408,442,443,444,462,463], Ni [406,408,430,443,…”

Section: Figurementioning

confidence: 99%

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

et al. 2018

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High-performance bioceramics are required for preventing failure and prolonging the life-time of bone grafting scaffolds and osseous implants. The proper identification and development of materials with extended functionalities addressing socio-economic needs and health problems constitute important and critical steps at the heart of clinical research. Recent findings in the realm of ion-substituted hydroxyapatite (HA) could pave the road towards significant developments in biomedicine, with an emphasis on a new generation of orthopaedic and dentistry applications, since such bioceramics are able to mimic the structural, compositional and mechanical properties of the bone mineral phase. In fact, the fascinating ability of the HA crystalline lattice to allow for the substitution of calcium ions with a plethora of cationic species has been widely explored in the recent period, with consequent modifications of its physical and chemical features, as well as its functional mechanical and in vitro and in vivo biological performance. A comprehensive inventory of the progresses achieved so far is both opportune and of paramount importance, in order to not only gather and summarize information, but to also allow fellow researchers to compare with ease and filter the best solutions for the cation substitution of HA-based materials and enable the development of multi-functional biomedical designs. The review surveys preparation and synthesis methods, pinpoints all the explored cation dopants, and discloses the full application range of substituted HA. Special attention is dedicated to the antimicrobial efficiency spectrum and cytotoxic trade-off concentration values for various cell lines, highlighting new prophylactic routes for the prevention of implant failure. Importantly, the current in vitro biological tests (widely employed to unveil the biological performance of HA-based materials), and their ability to mimic the in vivo biological interactions, are also critically assessed. Future perspectives are discussed, and a series of recommendations are underlined.

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Manganese Inhibits Viability of Prostate Cancer Cells

Abstract: Abstract. Background

Cited by 9 publications

References 26 publications

New Carbonate-Based Materials and Study of Cytotoxic Capacity in Cancer Cells

New Carbonate-Based Materials and Study of Cytotoxic Capacity in Cancer Cells

Cytotoxicity of Oleandrin Is Mediated by Calcium Influx and by Increased Manganese Uptake in Saccharomyces cerevisiae Cells

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

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