Manganese Exposure, Motor Symptom Progression May Be Dose-Related

Samson, Kurt

doi:10.1097/01.nt.0000512096.41679.50

Cited by 2 publications

(4 citation statements)

References 3 publications

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“…On secondary analysis of data from 418 South African manganese mine workers, the prevalence of parkinsonism as the primary outcome, defined by UPDRS3 ≥15, was 29.4% [18]. In this study, the prevalence of parkinsonism based on combined neurological examination and TCS findings was 42.2%, which is higher than the findings reported in previous studies [14][15][16][17][18]. This may be the result of our more sensitive approach combining neurological examination and brain sonography as a method for determining the prevalence of parkinsonism.…”

Section: Discussioncontrasting

confidence: 68%

“…On the other hand, several studies have shown that manganese exposure increases parkinsonism prevalence in welder populations. They estimated parkinsonism prevalence of about 15% based on the Unified Parkinson's Disease Rating Score Part III (UPDRS3) [14][15][16][17]. On secondary analysis of data from 418 South African manganese mine workers, the prevalence of parkinsonism as the primary outcome, defined by UPDRS3 ≥15, was 29.4% [18].…”

Section: Discussionmentioning

confidence: 99%

“…Studies have reported controversial findings on the association between manganese exposure and parkinsonism [10][11][12][13][14][15][16][17][18]. In this study, we assessed the association between manganese exposure and parkinsonism in foundry workers and the prevalence of parkinsonism based on neurological examination and transcranial brain sonography.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of Parkinsonism Among Foundry Workers in an Automobile Manufacturing Factory in Tehran

Rohani¹,

Kassiri²,

Abarghouei³

et al. 2022

Cureus

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BackgroundManganese, as an essential element, has neurotoxic effects on basal ganglia and causes parkinsonism, dystonia, and cognitive symptoms in exposed individuals. Transcranial sonography (TCS) is a noninvasive and easily accessible imaging modality for detecting the accumulation of trace elements in the basal ganglia. MethodologyIn a cross-sectional study of foundry workers of one of the automobile manufacturing companies in 2019, the prevalence of parkinsonism was assessed through neurological examination and brain parenchymal sonography or TCS. The prevalence of parkinsonism according to age, smoking, work experience, marital status, and exposure to manganese was determined. ResultsAmong 83 male workers, the prevalence of parkinsonism according to neurological examination, substantia nigra hyperechogenicity on TCS, lentiform nucleus hyperechogenicity, and totally was 33.7%, 9.6%, 10.8%, and 42.2%, respectively. The association between the prevalence of parkinsonism and age, smoking, work experience, marital status, and manganese exposure was evaluated. Parkinsonism according to lentiform nucleus hyperechogenicity was associated with smoking (odds ratio [OR] (95% confidence interval [CI]) = 26. 63 (2.38-178.71)) and work experience (OR (95% CI) = 7.18 (0.84-61.32)). ConclusionsAccording to this study, the prevalence of parkinsonism based on neurological examination or brain sonography findings was 42.2%. The implementation of this combined screening method might facilitate earlier detection of affected individuals among manganese-exposed workers.

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Section: Discussioncontrasting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Parkinsonism Among Foundry Workers in an Automobile Manufacturing Factory in Tehran

Rohani¹,

Kassiri²,

Abarghouei³

et al. 2022

Cureus

View full text Add to dashboard Cite

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“…This study, by examining the phenotype of 716 welding workers who were exposed to Mn, compared to the non-welder control group, estimated the prevalence of Parkinsonism in welders’ group to be about 15.6% [ 30 ]. Another study on 886 welders announced that the prevalence of Parkinsonism using the UPDRS-3 method was 15.2% [ 31 ]. A cohort study of 886 American welders, over a follow-up period of nearly 10 years, showed that with increasing cumulative doses of Mn, the progression of Parkinsonism included the progression of bradykinesia, rigidity, speech defects, and facial expression [ 32 ].…”

Section: Reviewmentioning

confidence: 99%

An Overview of the Relationship Between Occupational Manganese Exposure and Parkinsonism

Dirandeh¹,

Palizgir²,

Kassiri³

2022

Cureus

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Manganese (Mn) is an essential element used in many industries, such as welding, foundries, the production of metal alloys, especially stainless steel, and the production of dry batteries, pesticides, paints, and explosives. Individuals are exposed to Mn through inhalation of fumes, dermal absorption, and ingestion. This metal is an essential trace element required for normal growth, development, and cellular homeostasis. It has also toxic effects on the central nervous system and can cause Parkinsonism symptoms in exposed patients. Studies on human and animal models reveal that neurons of the globus pallidus, the cerebellum, pons, red nucleus, the thalamus, cortex, and the anterior horn of the spinal cord could be affected by Mn toxicity. Although the diagnosis of manganese-induced Parkinsonism is primarily clinical, there are some supporting features on brain MRI images that may be helpful to objectively distinguish it. This study was designed to review the ways of exposure to Mn, clinical symptoms in case of exposure, and discover the relationship between exposure to Mn and Parkinsonism in the working population.

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Manganese Exposure, Motor Symptom Progression May Be Dose-Related

Cited by 2 publications

References 3 publications

Prevalence of Parkinsonism Among Foundry Workers in an Automobile Manufacturing Factory in Tehran

Prevalence of Parkinsonism Among Foundry Workers in an Automobile Manufacturing Factory in Tehran

An Overview of the Relationship Between Occupational Manganese Exposure and Parkinsonism

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