An Overview of the Relationship Between Occupational Manganese Exposure and Parkinsonism

Dirandeh, Elham; Palizgir, Ali; Kassiri, Negin

doi:10.7759/cureus.32161

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…Exposure of workers in manganese mines was reported more than 60 years ago. Exposure to manganese is not only limited to manganese mines but also to workers who work in welding where they are exposed to the fumes that develop during this activity [ 18 ]. However, in subjects with Parkinsonism induced by metals such as manganese, copper, or pesticides such as paraquat, atypical Parkinsonism with early onset is induced in young workers [ 19 , 20 ].…”

Section: Parkinson’s Diseasementioning

confidence: 99%

Targets to Search for New Pharmacological Treatment in Idiopathic Parkinson’s Disease According to the Single-Neuron Degeneration Model

Huenchuguala,

Segura-Aguilar

2024

Biomolecules

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One of the biggest problems in the treatment of idiopathic Parkinson’s disease is the lack of new drugs that slow its progression. L-Dopa remains the star drug in the treatment of this disease, although it induces severe side effects. The failure of clinical studies with new drugs depends on the use of preclinical models based on neurotoxins that do not represent what happens in the disease since they induce rapid and expansive neurodegeneration. We have recently proposed a single-neuron degeneration model for idiopathic Parkinson’s disease that requires years to accumulate enough lost neurons for the onset of motor symptoms. This single-neuron degeneration model is based on the excessive formation of aminochrome during neuromelanin synthesis that surpass the neuroprotective action of the enzymes DT-diaphorase and glutathione transferase M2-2, which prevent the neurotoxic effects of aminochrome. Although the neurotoxic effects of aminochrome do not have an expansive effect, a stereotaxic injection of this endogenous neurotoxin cannot be used to generate a preclinical model in an animal. Therefore, the aim of this review is to evaluate the strategies for pharmacologically increasing the expression of DT diaphorase and GSTM2-2 and molecules that induce the expression of vesicular monoamine transporter 2, such as pramipexole.

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Section: Parkinson’s Diseasementioning

confidence: 99%

Targets to Search for New Pharmacological Treatment in Idiopathic Parkinson’s Disease According to the Single-Neuron Degeneration Model

Huenchuguala,

Segura-Aguilar

2024

Biomolecules

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“…Excess Fe and Cu, both redox-active metals, produce ROS and damage neurons. Excess Mn also induces oxidative stress and causes neurotoxicity, termed "manganism," the symptoms of which are similar to Parkinson's disease [3]. Excess Zn and Cu play key roles in neuronal death after transient global ischemia [4].…”

Section: Introductionmentioning

confidence: 99%

Dietary Trace Elements and the Pathogenesis of Neurodegenerative Diseases

2023

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Trace elements such as iron (Fe), zinc (Zn), copper (Cu), and manganese (Mn) are absorbed from food via the gastrointestinal tract, transported into the brain, and play central roles in normal brain functions. An excess of these trace elements often produces reactive oxygen species and damages the brain. Moreover, increasing evidence suggests that the dyshomeostasis of these metals is involved in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease, prion diseases, and Lewy body diseases. The disease-related amyloidogenic proteins can regulate metal homeostasis at the synapses, and thus loss of the protective functions of these amyloidogenic proteins causes neurodegeneration. Meanwhile, metal-induced conformational changes of the amyloidogenic proteins contribute to enhancing their neurotoxicity. Moreover, excess Zn and Cu play central roles in the pathogenesis of vascular-type senile dementia. Here, we present an overview of the intake, absorption, and transport of four essential elements (Fe, Zn, Cu, Mn) and one non-essential element (aluminum: Al) in food and their connections with the pathogenesis of neurodegenerative diseases based on metal–protein, and metal–metal cross-talk.

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Effects of Manganese and Iron, Alone or in Combination, on Apoptosis in BV2 Cells

Fang¹,

Gan²,

Peng³

et al. 2023

Biol Trace Elem Res

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An Overview of the Relationship Between Occupational Manganese Exposure and Parkinsonism

Cited by 3 publications

References 34 publications

Targets to Search for New Pharmacological Treatment in Idiopathic Parkinson’s Disease According to the Single-Neuron Degeneration Model

Targets to Search for New Pharmacological Treatment in Idiopathic Parkinson’s Disease According to the Single-Neuron Degeneration Model

Dietary Trace Elements and the Pathogenesis of Neurodegenerative Diseases

Effects of Manganese and Iron, Alone or in Combination, on Apoptosis in BV2 Cells

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