Manganese Complexes of Curcumin Analogues: Evaluation of Hydroxyl Radical Scavenging Ability, Superoxide Dismutase Activity and Stability towards Hydrolysis

Vajragupta, Opa; Boonchoong, Preecha; Berliner, Lawrence J.

doi:10.1080/10715760310001643339

Cited by 101 publications

(64 citation statements)

References 24 publications

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“…The inhibition of cancer cell invasion by bDMC highlights its enhanced A c c e p t e d M a n u s c r i p t 4 antimetastasis potency [26]. The synthetic derivative DAC shows higher antibacterial activity against multiresistant bacteria [27] and a stronger nitric oxide (NO) and O 2 •-anion scavenging activity [28,29], although it has slightly lower apoptotic activity on AK-5 rat histiocytoma cells [30].…”

Section: Introductionmentioning

confidence: 99%

Curcumin derivatives: Molecular basis of their anti-cancer activity

Basile

Ferrari

Lazzari

et al. 2009

Biochemical Pharmacology

160

125

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Curcumin, a phenolic compound from the plant Curcuma longa L., has shown a wide-spectrum of chemopreventive, anti-oxidant and anti-tumor properties. Although its promising chemotherapeutic activity, preclinical and clinical studies highlight Curcumin limited therapeutic application due to its instability in physiological conditions. To improve its stability and activity, many derivatives have been synthesized and studied, among which bis-DemethoxyCurcumin (bDMC) and diAcetylCurcumin (DAC). In this report, we show that both bDMC and DAC are more stable than Curcumin in physiological medium. To explore the mechanism of their chemotherapeutic effect, we studied their role in proliferation in the HCT116 human colon cancer cells. We correlated kinetic stability and cellular uptake data to their biological effects. Both bDMC and DAC impair correct spindles formation and induce a p53-and p21 CIP1/WAF1 -independent mitotic arrest, which is more stable and long-lasting for bDMC. A subsequent p53/p21 CIP1/WAF1 -dependent inhibition of G1 to S transition is triggered by Curcumin and DAC as a consequence of the mitotic slippage, preventing postmitotic cells from re-entering the cell cycle. Conversely, the G1/S arrest induced by bDMC is a direct effect of the drug and concomitant to the mitotic block. Finally, we demonstrate that bDMC induces rapid DNA double-strand breaks, moving for its possible development in anti-cancer clinical applications.

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Section: Introductionmentioning

confidence: 99%

Curcumin derivatives: Molecular basis of their anti-cancer activity

Basile

Ferrari

Lazzari

et al. 2009

Biochemical Pharmacology

160

125

View full text Add to dashboard Cite

show abstract

“…Again a group of researchers has reported that curcumin manganese complex has more reliable neuroprotective activity than curcumin itself both in vitro and in vivo. Further they concluded that the complex might be useful as a neuroprotective agent to treat acute brain pathologies associated with NO-induced neurotoxicity and oxidative stress induced neuronal damage like epilepsy, stroke and traumatic brain injury [59,60].…”

Section: Strategies To Increase Bioavailability Of Curcuminmentioning

confidence: 99%

Role of Curcumin in Treatment of Alzheimer Disease

Mukhopadhyay¹,

Ruidas²,

Chaudhury³

2017

Int J Neurorehabilitation Eng

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A lot of research findings support that curcumin (diferuloyl methane) has antioxidant, anti-inflammatory and antitumor activity. In India, curcumin has a widespread use as food additive and herbal medicine for human diseases without any side effect. Though curcumin is well established as an anticancer agent but there are a few reports about its promising role against amyloid diseases. According to recent finding curcumin play a crucial inhibitory role in pathophysiology of Alzheimer's disease (AD). Oral administration of curcumin or its metabolites has shown the inhibition of Aβ deposition, Aβ oligomerization and tau phosphorylation in the brain of AD animal model including behavioural improvement. But still it is unknown whether the curcumin is directly involved in those processes or enhance those mechanisms. Thus in this review we want to focus on overall mechanism of curcumin in AD. Some strategies to overcome the problem of low absorption and fast clearance of curcumin nanoparticles have also been proposed.

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“…7 RNS are derived from nitric oxide through the reaction with O2 -• to form ONOO -. RSS are easily formed from thiols by reaction with ROS.…”

Section: Oxidantsmentioning

confidence: 99%