Antioxidants: An Overview on the Natural and Synthetic Types

Atta, Emad M; Mohamed, Nawal H.; Abdelgawad, Ahmed A. M.

doi:10.17628/ecb.2017.6.365-375

Cited by 84 publications

(61 citation statements)

References 84 publications

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“…As a result, nowadays, the research of natural antioxidants, for improving oil oxidative stability and for replacing synthetic antioxidants, has attracted more and more attention from researchers [1,8]. When compared to synthetic antioxidants, natural antioxidants have many advantages [9]. They are considered to be safe and readily acceptable by consumers.…”

Section: Introductionmentioning

confidence: 99%

Untargeted Metabolomics to Evaluate the Stability of Extra-Virgin Olive Oil with Added Lycium barbarum Carotenoids during Storage

Montesano

Rocchetti

Cossignani

et al. 2019

Foods

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A carotenoid-rich extract from Lycium barbarum L. was added to extra virgin olive oil (EVOO), obtaining a carotenoid-enriched oil (EVOOCar). The oxidative stability of EVOO and EVOOCar was evaluated during long-term storage of 28 weeks at room temperature, by measuring some classical parameters (acidity and peroxide values, spectrophotometric coefficients, fatty acid composition) and the content of minor compounds (i.e., α-tocopherol and lutein). At the end of the storage, higher content (p < 0.01) of α-tocopherol in EVOOCar in respect to EVOO were observed. Zeaxanthin dipalmitate, the most abundant carotenoid compound of Goji berries, decreased slightly (p < 0.05) in EVOOCar until the end of the storage. In regard to polyphenols, an ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry (UHPLC/QTOF-MS) using untargeted metabolomics was carried out. This latter approach discriminated the two oil samples during long-term storage, allowing to identify also the phenolic classes most exposed to significant variations during storage (i.e., mainly lignans and flavones). Besides, the addition of Goji carotenoids preserved the stability of tyrosol equivalents in EVOOCar during long-term storage. These results highlighted that the enrichment of EVOO with a carotenoid-rich extract can improve the shelf-life and nutritional value of added-oil, protecting EVOO natural antioxidants during long-term storage.

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Section: Introductionmentioning

confidence: 99%

Untargeted Metabolomics to Evaluate the Stability of Extra-Virgin Olive Oil with Added Lycium barbarum Carotenoids during Storage

Montesano

Rocchetti

Cossignani

et al. 2019

Foods

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“…During diabetes, hyperglycemia causes auto-oxidation of glucose and stimulates OS through excessive free radical production. The release of free radicals causes damage to biological systems by abstracting electrons from macromolecules, thereby causing instability and disintegration [53]. For instance, peroxidation of polyunsaturated lipids on sperm membrane has been reported to cause structural alterations of the biological cell membranes as well as a change in membrane stability and function [49].…”

Section: Assessment Of Lipid Peroxidation Of Testicular and Epididymamentioning

confidence: 99%

Potential Antioxidative Effects of Kolaviron on Reproductive Function in Streptozotocin-Induced Diabetic Wistar Rats

Manirafasha¹,

Oyenihi²,

Brooks³

et al. 2019

Antioxidants

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The present study investigated the effects of Kolaviron (KV) on the testicular and epididymal tissue antioxidant status in streptozotocin (STZ)-induced diabetic rats. Diabetes was induced by a single intraperitoneal injection of STZ at 50 mg/ kg body weight. The antioxidant status was studied by evaluating epididymal and testicular levels of malondialdehyde (MDA), a lipid peroxidation (LPO) marker, and the activities of catalase (CAT) glutathione peroxidase (GPX) and superoxide dismutase (SOD) were also assessed using biochemical techniques. Diabetes induction resulted in testicular and epididymal LPO and adversely affected the activities of antioxidant enzymes evident by a noticeable decrease in enzyme activity in both tissues. The potential antioxidative effects of KV in the testicular and epididymal tissues of STZ-induced diabetes were revealed by its ability to mitigate against LPO and increase the activity of antioxidant defense enzymes in the reproductive tissues studied. KV might potentially be used as an antioxidant as well as antidiabetic treatment; however, further studies are needed.

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“…Though there are lots of synthetic antioxidants easily available in the market but nowadays people are becoming more concerned about the safety issues of using synthetic products in conventional food. They not only extend shelf life of packaged food but also damage our health on consuming daily basis . In this regard, mushroom polysaccharide as a novel and less toxic substitute could be of great choice to food industries.…”

Section: Introductionmentioning

confidence: 99%

“…They not only extend shelf life of packaged food but also damage our health on consuming daily basis. [11,12] In this regard, mushroom polysaccharide as a novel and less toxic substitute could be of great choice to food industries.…”

Section: Introductionmentioning

confidence: 99%

Crude polysaccharide from a wild mushroom enhances immune response in murine macrophage cells by TLR/NF-κB pathway

Ghosh

Khatua

Acharya

2019

Journal of Pharmacy and Pharmacology

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Objective Mushroom crude polysaccharides offer a complete package of various medicinal activities. In this context, the present study aimed to unveil structural and biomedical properties of crude polysaccharide (MLHWP) obtained from an edible wild mushroom Macrocybe lobayensis (R. Heim) Pegler & Lodge. Method Chemical characterization was accomplished with the help of spectrophotometry, Fourier‐transform infrared spectroscopy, HPTLC and GC‐MS. Immunomodulatory activity of the crude polysaccharide and its signalling mechanism was assessed using RAW 264.7 cells. Furthermore, antioxidant activity was analysed based on radical scavenging, metal ion chelating and reducing effect. Key findings Compositional study revealed that MLHWP possessed triple helical structure and its backbone consisted of β‐linked glucan along with xylose, rhamnose, mannose and galactose. Investigation on bioactive potency revealed that MLHWP augmented macrophage activity in terms of viability, phagocytosis, NO and ROS generation. Gene expression studies indicated that MLHWP signalled through TLR and modulated expression of immunomodulation‐related genes including NF‐κB, COX‐2, IFN‐γ, TNF‐α, iNOS and Iκ‐βα. Besides, MLHWP displayed noticeable antioxidant potential as reflected in all investigating assays. Conclusions Overall, the results portrayed possibility of MLHWP as pharmaceutical agent with multidimensional application.

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Antioxidants: An Overview on the Natural and Synthetic Types

Cited by 84 publications

References 84 publications

Untargeted Metabolomics to Evaluate the Stability of Extra-Virgin Olive Oil with Added Lycium barbarum Carotenoids during Storage

Untargeted Metabolomics to Evaluate the Stability of Extra-Virgin Olive Oil with Added Lycium barbarum Carotenoids during Storage

Potential Antioxidative Effects of Kolaviron on Reproductive Function in Streptozotocin-Induced Diabetic Wistar Rats

Crude polysaccharide from a wild mushroom enhances immune response in murine macrophage cells by TLR/NF-κB pathway

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