Management of relapsing–remitting multiple sclerosis in Qatar: an expert consensus

Deleu, Dirk; Canibaño, Beatriz; Mesraoua, Boulenouar; Adeli, G M; Abdelmoneim, Mohamed S.; Ali, Yasir; Elalamy, Osama; Melikyan, Gayane; Boshra, Amir

doi:10.1080/03007995.2019.1669378

Cited by 3 publications

(3 citation statements)

References 74 publications

(76 reference statements)

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“…Poor adherence to DMT regiments is common among patients with MS and due to multiple factors including side effects, efficacy, dissatisfaction with treatment, and demographic and other factors [76,77]. Intensive monitoring requirements or the need to visit hospitals for infusions of some DMTs adds to the burden of treatment with some DMTs [78].…”

Section: Discussionmentioning

confidence: 99%

Position of Cladribine Tablets in the Management of Relapsing-Remitting Multiple Sclerosis: An Expert Narrative Review From the United Arab Emirates

Inshasi

Al-Fahad²,

Alsaadi³

et al. 2021

Neurol Ther

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The use of immune reconstitution therapies (IRT) in patients with relapsing-remitting multiple sclerosis (RRMS) is associated with a prolonged period of freedom from relapses in the absence of continuously applied therapy. Cladribine tablets is a disease-modifying treatment (DMT) indicated for highly active relapsing multiple sclerosis (MS) as defined by clinical or imaging features. Treatment with cladribine tablets is effective and well tolerated in patients with active MS disease and have a low burden of monitoring during and following treatment. In this article, an expert group of specialist neurologists involved in the care of patients with MS in the United Arab Emirates provides their consensus recommendations for

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Section: Discussionmentioning

confidence: 99%

Position of Cladribine Tablets in the Management of Relapsing-Remitting Multiple Sclerosis: An Expert Narrative Review From the United Arab Emirates

Inshasi

Al-Fahad²,

Alsaadi³

et al. 2021

Neurol Ther

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“…6 , 7 The authors, a group of neurologists who care routinely for patients with RMS in Qatar, provided expert recommendations on the management of RMS in Qatar in 2020. 8 The purpose of this article is to provide an update with recommendations specifically on the therapeutic use of CladT in people with RMS, focussed mainly on identifying the most appropriate group of patients to be considered for this treatment.…”

Section: Introductionmentioning

confidence: 99%

Practical Guidance on the Use of Cladribine Tablets in the Management or Relapsing Multiple Sclerosis: Expert Opinion from Qatar

Deleu,

Garcia Canibano,

Elalamy

et al. 2023

DNND

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The increasing availability of high-efficacy disease-modifying therapies (DMT) for the management of relapsing multiple sclerosis (RMS) has increased the potential for individualised patient management but has added complexity to the design of treatment regimens. The long-term application of immune reconstitution therapy (IRT) is supported by an increasing database of real world studies that have added important information on the long-term safety and efficacy of this approach. Cladribine tablets (CladT) is an IRT given as two annual short courses of treatment, following which a majority of patients then demonstrate no significant MS disease activity over a period of years. Whether, and how, to treat patients beyond the first two years of treatment remains a matter for debate, as clinical evidence accumulates. We, a group of neurologists who manage people with RMS in Qatar, provide our expert consensus recommendations on the application and long-term management of CladT therapy based on our experience with treatment in the last 5 years. These include pragmatic recommendations for people with MS disease activity in years 3 and 4 (ie up to four years following first dose of CladT), and for people with or without MS disease activity in subsequent years. We believe our recommendations will help to ensure the optimal application of CladT-based IRT, with the potential benefit for the patient of achieving prolonged periods free of both MS disease symptoms and the burden of regular applications of immunosuppressive DMT.

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“…Relapsing-remitting MS (RRMS), the most frequent type of MS at the time of diagnosis, is characterized by clearly defined relapses (attacks or exacerbations) followed by partial or complete recovery [8,9]. Psychological troubles represent one of the major problems encountered in MS patients [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Psychiatric Comorbidities among University Students with Relapsing-Remitting Multiple Sclerosis

Mustafa

Salama

Jawad

et al. 2022

INDJ

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Background: Multiple sclerosis (MS) has been reported to be associated with psychological manifestations like depression, anxiety, and depression. Its presence in university students may impact their academic performance. As the relapsing-remitting type (RRMS) is the commonest MS type, we conducted this study to evaluate the prevalence and severity of the previous psychological manifestations in University students diagnosed with RRMS. The impact of MS on their academic performance was also assessed. Patients and Methods: This case-control study included 65 students diagnosed with RRMS in addition to the same number of healthy controls. Psychological manifestations were evaluated via the Arabic form of DASS (depression, anxiety, and stress score), while academic performance was assessed via the GPA (grade point average). Results: Patient criteria, including age and gender, were statistically comparable between the two groups. The three components of DASS expressed significantly higher values in cases compared to controls, indicating increased prevalence and severity of psychological issues in association with RRMS. MS was associated with a significant decline in the student’s academic performance as had median values of 1 and 3 in cases and controls, respectively. Conclusion: MS is associated with a significant increase in both prevalence and severity of depression, anxiety, and depression compared to the normal healthy population. MS also has a significant negative impact on the academic performance of these students.

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Management of relapsing–remitting multiple sclerosis in Qatar: an expert consensus

Cited by 3 publications

References 74 publications

Position of Cladribine Tablets in the Management of Relapsing-Remitting Multiple Sclerosis: An Expert Narrative Review From the United Arab Emirates

Position of Cladribine Tablets in the Management of Relapsing-Remitting Multiple Sclerosis: An Expert Narrative Review From the United Arab Emirates

Practical Guidance on the Use of Cladribine Tablets in the Management or Relapsing Multiple Sclerosis: Expert Opinion from Qatar

Psychiatric Comorbidities among University Students with Relapsing-Remitting Multiple Sclerosis

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