Management of Pelvic Floor Disorder in a Diethylstilbestrol Daughter

Chung, Christopher; Cao, Suzanne; Wakabayashi, Grace; Han, Ernest

doi:10.1080/08998280.2017.11929618

Baylor University Medical Center Proceedings

2017

DOI: 10.1080/08998280.2017.11929618

|View full text |Cite

Management of Pelvic Floor Disorder in a Diethylstilbestrol Daughter

Christopher Chung¹,

Suzanne Cao²,

Grace Wakabayashi³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2021

2023

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 4 publications

(1 reference statement)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, defecatory disorder, sexual disorders, and dyspareunia have been reported. [3][4][5][6][7][8][9]. Collagen metabolism disorders, namely, changes in the extracellular matrix, play an important role in the GP formation and progression.…”

mentioning

confidence: 99%

On the Results of Detectability of the Level of C-Terminal Telopeptide of Type I Collagen in Patients with Post Hysterectomy Genital Prolapse in Uzbek Population

2023

AJBSR

View full text Add to dashboard Cite

The article presents an assessment of the levels of the C-terminal type I collagen telopeptide in patients with Post-Hysterectomy Genital Prolapse (PHGP). The results of an EIA study on the detectability of the level of C-terminal telopeptide of type I Collagen (CTX) in patients with PHGP amounted to 67.3% of cases. Among background diseases, patients with PHGP were most often diagnosed with urinary tract infections (47.3%), metabolic syndrome (obesity) (23.6%), and anemia (30.9%), respectively.Post-Hysterectomy Pelvic Organ Prolapse (PHPOP) is a multifactorial disease with a syndromic course, characterized by a genetic predisposition to the formation and progression of the pelvic floor muscles [1][2][3][4]. Genital prolapse, which has an early manifestation, is also characterized by a high recurrence rate after surgical treatment. The clinical manifestations of genital prolapse are urgent incontinence in more than 84.7% of female patients. Also, defecatory disorder, sexual disorders, and dyspareunia have been reported. [3][4][5][6][7][8][9]. Collagen metabolism disorders, namely, changes in the extracellular matrix, play an important role in the GP formation and progression. During the remodeling of the components of the extracellular matrix, the processes of synthesis and degradation of collagen filaments are unbalanced, and collagen bonds between individual vascular smooth muscle cells, fibroblasts are lost. In this process, matrix metalloproteinase (MMP) plays a special role in GP pathogenesis [10,11]. Influenced by MMP-1, type I-III collagen molecules are broken down [11].

show abstract

mentioning

confidence: 99%

On the Results of Detectability of the Level of C-Terminal Telopeptide of Type I Collagen in Patients with Post Hysterectomy Genital Prolapse in Uzbek Population

2023

AJBSR

View full text Add to dashboard Cite

show abstract

Clinical and anamnestic and biological candidates for participation in the mechanisms of genital prolapse formation in women

Milyaeva

Ковалев

Bortnik

et al. 2021

jour

View full text Add to dashboard Cite

Introduction. The article presents an overview of the results of modern evidence-based scientific research on the mechanisms of formation of genital prolapse as one of the fundamental causes of pelvic floor muscle insufficiency in women. A systematic analysis of the current literature data on the involvement of clinical, anamnestic and pathogenetic motives in the development of pelvic organ prolapse in women was carried out.Objective: to expand the understanding of the role of anamnestic and biological factors in the pathogenesis of genital prolapse in women.Material and method. The review includes the scale of publications of domestic and foreign authors included in the PubMed database on this topic with a search depth of 20 years. The criteria for inclusion of articles for the system analysis were articles corresponding to the topic chosen for the study of the problem of gynecology, namely, the pathogenesis of genital prolapse in women with a search depth of twenty years. The criteria for exclusion from the study are the age of published scientific works, exceeding a twenty-year period, and inconsistency with the chosen top.Results. The conducted analysis demonstrates the fundamental role of epigenetic factors and molecular genetic predisposition in patients in the progression of genital prolapse which makes it possible to develop personalized prediction and prevention of pelvic floor dysfunction in women, prevention of social burnout.Conclusion. Further study of the mechanisms of formation, determination of the most significant molecular and genetic polymorphisms that increase the risk of pelvic organ prolapse in women, is a promising vector of scientific research. These studies will help to form a pathophysiological basis that allow for a thorough examination to identify a predisposition to the development of a severe disease long before its occurrence.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Management of Pelvic Floor Disorder in a Diethylstilbestrol Daughter

Cited by 2 publications

References 4 publications

On the Results of Detectability of the Level of C-Terminal Telopeptide of Type I Collagen in Patients with Post Hysterectomy Genital Prolapse in Uzbek Population

On the Results of Detectability of the Level of C-Terminal Telopeptide of Type I Collagen in Patients with Post Hysterectomy Genital Prolapse in Uzbek Population

Clinical and anamnestic and biological candidates for participation in the mechanisms of genital prolapse formation in women

Contact Info

Product

Resources

About