On the Results of Detectability of the Level of C-Terminal Telopeptide of Type I Collagen in Patients with Post Hysterectomy Genital Prolapse in Uzbek Population

Abstract

The article presents an assessment of the levels of the C-terminal type I collagen telopeptide in patients with Post-Hysterectomy Genital Prolapse (PHGP). The results of an EIA study on the detectability of the level of C-terminal telopeptide of type I Collagen (CTX) in patients with PHGP amounted to 67.3% of cases. Among background diseases, patients with PHGP were most often diagnosed with urinary tract infections (47.3%), metabolic syndrome (obesity) (23.6%), and anemia (30.9%), respectively.Post-Hysterectomy Pelvic Organ Prolapse (PHPOP) is a multifactorial disease with a syndromic course, characterized by a genetic predisposition to the formation and progression of the pelvic floor muscles [1][2][3][4]. Genital prolapse, which has an early manifestation, is also characterized by a high recurrence rate after surgical treatment. The clinical manifestations of genital prolapse are urgent incontinence in more than 84.7% of female patients. Also, defecatory disorder, sexual disorders, and dyspareunia have been reported. [3][4][5][6][7][8][9]. Collagen metabolism disorders, namely, changes in the extracellular matrix, play an important role in the GP formation and progression. During the remodeling of the components of the extracellular matrix, the processes of synthesis and degradation of collagen filaments are unbalanced, and collagen bonds between individual vascular smooth muscle cells, fibroblasts are lost. In this process, matrix metalloproteinase (MMP) plays a special role in GP pathogenesis [10,11]. Influenced by MMP-1, type I-III collagen molecules are broken down [11].