Management of Maxillary Aspergillosis in a Patient with Diabetic Mellitus Followed by Prosthetic Rehabilitation

Rudagi, B. M.; Halli, Rajshekhar; Kalburge, Jitendra V; Joshi, Manjrii; Munde, Anita; Saluja, Harish

doi:10.1007/s12663-010-0076-x

Cited by 4 publications

(3 citation statements)

References 10 publications

(11 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The first step in successful management of aggressive aspergillosis is resolution of the predisposing factors, such as the metabolic abnormalities in diabetic patients or using granulocyte colony-stimulating factor in hematological patients with ongoing neutropenia. 1,12 Laboratory examination holds an important role in this early step. The earlier an abnormality is observed in the laboratory result, the sooner prompt management of the hyperglycemia and ketoacidosis can be implemented.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Appropriate Total Rehabilitation in the Bilateral Maxillectomy Defected Diabetic Patient Secondary to Aggressive Aspergillosis

Mustakim¹,

Eo²,

Kim³

et al. 2023

Journal of Craniofacial Surgery

View full text Add to dashboard Cite

Aggressive aspergillosis is a life-threatening fungal infection with rapid progress, mainly affecting the maxillofacial area, especially the nose and paranasal sinuses, in patients with immunocompromised conditions such as diabetes mellitus. Aggressive aspergillosis infection should be differentiated from other invasive fungal sinusitis for early recognition with correct prompt treatment. The main treatment is aggressive surgical debridement such as maxillectomy. Although aggressive debridement should be performed, preservation of the palatal flap should be considered for better postoperative outcomes. In this manuscript, we report the case of a diabetic patient with aggressive aspergillosis affecting the maxilla and paranasal sinuses and describe the appropriate surgical management and prosthodontic rehabilitation.

show abstract

Section: Discussionmentioning

confidence: 99%

“…A ggressive aspergillosis is a rare but invasive fulminant opportunistic fungal infection that occurs most often in diabetic and immunocompromised patients, leading to high morbidity and mortality. 1 Aspergillus fumigatus is the most common species causing the fungal rhinosinusitis. Fungal rhinosinusitis can be either invasive or noninvasive.…”

mentioning

confidence: 99%

Appropriate Total Rehabilitation in the Bilateral Maxillectomy Defected Diabetic Patient Secondary to Aggressive Aspergillosis

Mustakim¹,

Eo²,

Kim³

et al. 2023

Journal of Craniofacial Surgery

View full text Add to dashboard Cite

show abstract

“…Aspergillus fumigatus and Aspergillus flavus species were the majority of opportunistic oral mucosal fungal infections. 77,78 The drug-free patches did not show microbial inhibition zones against Aspergillus fumigatus and Aspergillus flavus, while both drugs loaded patches showed clear microbial inhibition zones for Aspergillus fumigatus and Aspergillus flavus. The presence of TR caused the antifungal activity as shown in Table 2.…”

Section: Antifungal Studiesmentioning

confidence: 95%

Development of mucoadhesive modified kappa‐carrageenan/pectin patches for controlled delivery of drug in the buccal cavity

et al. 2021

View full text Add to dashboard Cite

In this study, modified kappa-carrageenan/pectin hydrogel patches were fabricated for treatment of buccal fungal infections. For this purpose, kappa-carrageenan-gacrylic acid was modified with different thiolated agents (L-cysteine and 3-mercaptopropionic acid), and the thiol content of the resulting modified kappacarrageenan was confirmed by elemental analyzer. Then, the hydrogel patches were fabricated, and characterized by Fourier-transform infrared spectroscopy, thermogravimetric analysis, ex vivo mucoadhesion test, and swelling behavior.Triamcinolone acetonide was added either directly or by encapsulating within the poly(lactic-co-glycolic acid) nanoparticles. The release amount of the drug from the directly loaded patch was 7.81 mg/g polymer, while it was 3.28 mg/g polymer for the encapsulated patch with the same content at 7 hr. The hydrogel patches had no cytotoxicity by cell culture studies. Finally, the drug loaded hydrogel patches were demonstrated antifungal activity against Aspergillus fumigatus and Aspergillus flavus.These results provide that the novel modified kappa-carrageenan and pectin based buccal delivery system has promising antifungal property, and could have advantages compared to conventional buccal delivery systems.antifungal activity, buccal drug delivery, thiolated kappa-carrageenan, triamcinolone acetonide | INTRODUCTIONUlcerative diseases in the mucous membrane of the buccal cavity are observed as a result of a wide etiological reasons such like infections, traumas, immunological disorders, or side effects of some drugs. 1,2 Amongst these, mucocutaneous diseases are observed frequently such as lichen planus, 3 aphthous stomatitis, 4 erythema multiforme, and Behçet's disease. 5 Conventional drug applied to the oral mucosa are generally in the form of in situ gels, 6 pastes, 7 or mouthwashes. 8 These forms have some drawbacks due to causing high-level drug concentration and in the oral cavity for a short period of time. 9 Therefore, the desired therapeutic drug concentration for mucosal and transmucosal absorption could not be adequately provided for healing. To overcome the limitations of the conventional delivery systems, use of oral mucoadhesive systems in the topical treatment of oral ulcerative diseases is a more rational approach. The oral mucoadhesive systems could be prepared in various forms such as buccal adhesive patches, films, and tablets. 10,11

show abstract

Combined Orofacial Aspergillosis and Mucormycosis: Fatal Complication of a Recurrent Paediatric Glioma—Case Report and Review of Literature

et al. 2016

View full text Add to dashboard Cite

Mucormycosis and aspergillosis are two opportunistic fungal infections, which can evolve into life-threatening complications. They generally affect patients with relevant risk factors such as immunocompromisation or long-term use of antibiotics or corticosteroids. Treatment usually combines medical and surgical approaches, often including extended necrosectomies, although the prognosis of generalized fungal infections is very poor. In this paper, we present the case of a 17-year-old girl affected by combined aspergillosis and mucormycosis, following treatment of a recurrent glioma. The patient was hospitalized for a suspected cellulitis of the right hemi-face, involving frontal maxillary area and the upper airways and was immediately put on intravenous antibiotic therapies; after performing nasal septum and maxillary biopsies, concomitant mucormycosis and aspergillosis were diagnosed and antimycotic therapy with liposomal B-amphotericin was administered. After evaluation by the oral surgeon and otolaryngologist, surgical cranio-facial necrosectomy was suggested, but refused by the parents of the patient. The girl died only few days later, due to a respiratory arrest. Awareness of this pathology with prompt diagnosis and early treatment may improve the outcome of these infections and reduce the mortality.

show abstract

Management of Maxillary Aspergillosis in a Patient with Diabetic Mellitus Followed by Prosthetic Rehabilitation

Cited by 4 publications

References 10 publications

Appropriate Total Rehabilitation in the Bilateral Maxillectomy Defected Diabetic Patient Secondary to Aggressive Aspergillosis

Appropriate Total Rehabilitation in the Bilateral Maxillectomy Defected Diabetic Patient Secondary to Aggressive Aspergillosis

Development of mucoadhesive modified kappa‐carrageenan/pectin patches for controlled delivery of drug in the buccal cavity

Combined Orofacial Aspergillosis and Mucormycosis: Fatal Complication of a Recurrent Paediatric Glioma—Case Report and Review of Literature

Contact Info

Product

Resources

About