Management of congenital pouch colon based on the Saxena-Mathur classification

Mathur, Praveen; Saxena, Amulya K.; Simlot, Anita

doi:10.1016/j.jpedsurg.2009.01.035

Cited by 29 publications

(30 citation statements)

References 20 publications

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“…Its presence in these types would not carry any clinical significance, as the pouch has to be removed anyway [14] .…”

Section: Discussionmentioning

confidence: 99%

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Histopathological and Immunohistochemical Findings in Congenital Pouch Colon: A Prospective Study

Udawat¹,

Nunia²,

Mathur³

et al. 2017

Pathobiology

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Background: There is a paucity of literature on the histopathological aspects of congenital pouch colon (CPC) and immunohistochemical (IHC) assessment has not been reported. So we planned to study the histopathological and IHC findings within the spectrum of CPC and compare the findings with the normal colon. Methods: This is a descriptive prospective study on CPC patients. There were 49 cases of CPC (42 males and 7 females) and 13 controls. Histological examination was done using hematoxylin and eosin and Masson trichrome stain. IHC analysis was done with actin, myosin, and desmin antibodies, and neuron-specific enolase and S100 markers for counting ganglionic cells. Results: Histologically, congestion, edema and hemorrhage were seen in mucosa, submucosa, and serosa. Muscle layers were disrupted and divided into bands. An additional muscle coat inside of the muscularis propria was seen in CPC types 1 and 2. Mature ganglionic cells were reduced and muscle layers showed reduced and patchy positivity for smooth muscle actin, myosin, and desmin compared to a normal colon. Conclusions: Histopathological and IHC findings suggest that CPC has distinct defects in the neuromusculature.

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“…Its presence in these types would not carry any clinical significance, as the pouch has to be removed anyway [14] .…”

Section: Discussionmentioning

confidence: 99%

“…In restorative surgery, coloplasty, i.e., excision of the redundant pouch and tubularization of the residual pouch, is done. So the type 1 and 2 CPC specimens for histopathology were obtained at this stage of the surgery [14] .…”

Section: Methodsmentioning

confidence: 99%

Histopathological and Immunohistochemical Findings in Congenital Pouch Colon: A Prospective Study

Udawat¹,

Nunia²,

Mathur³

et al. 2017

Pathobiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Our three cases represent a very rare form of CPC type I [1] without genitourethral fistula. In the literature Mathur et al described one case out of 80 [4], Chadha et al 3 cases out of 41 [7] and Sharma et al 3 out of 68 cases [11].…”

Section: Discussionmentioning

confidence: 99%

“…Many of these reports addressed possible reasons for severe complications like re-dilatation of the tubularized colonic pouch after pull-through surgery [4,6,8,10,11]. Gangopadhyaya et al reported in their large series on the histopathologic examinations of the resected pouches and pointed out that these structures have abnormally developed tissue and need to be resected for better functional outcome [9].…”

Section: Discussionmentioning

confidence: 99%