Management of an unusual peripheral giant cell granuloma: A diagnostic dilemma

Mannem, Satheesh; Chava, Vijay Kumar

doi:10.4103/0976-237x.94556

Cited by 19 publications

(33 citation statements)

References 8 publications

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“…As to location, the lesion may arise in both the anterior and posterior regions of the gingiva or alveolar ridge. The mandible is more affected than the maxilla (20,21) . PGCL may also arise in areas adjacent to dental implants (31) .…”

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

“…Previously, the lesion was called peripheral giant cell reparative granuloma. However, its reparative effect has not been proved yet, hence osteoclast activity seems doubtful (11,20,34) .…”

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

“…It is a well-defined lesion with exophytic growth. Additionally, it may be pedunculated, sessile or it may not present areas of ulceration (2,11,12,20,27,31,34) . It may develop at any age, predominantly in the first to sixth decade of life, especially from 31 to 41 years of age.…”

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

“…According to Fanourakis et al (12) , radiological examination is essential to determine if the lesion arises from the gingiva (peripheral) or bone (central) growing towards the surface. Dental resorption is rare (3,20) .…”

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

“…They may also be observed in areas of mature or immature reactive bone formation or dystrophic calcifications. The epithelial lining may be hyperplastic and/or ulcerated (11,20,34) . Two types of giant cells have been described: type A cells, which correspond to eosinophilic polynuclear cells with abundant and diffuse cytoplasm and irregular nuclei, containing chromatin spread along the inner membrane; type B cells, which have regular and well-defined shape and more abundant and dense cytoplasm (12,16) .…”

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

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Peripheral and central giant cell lesions: etiology, origin of giant cells, diagnosis and treatment

Vasconcelos

Vasconcelos²,

Queiroz

2013

J. Bras. Patol. Med. Lab.

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Introduction and objective: The peripheral and central giant cell lesions (PGCL and CGCL) are a group of pathological entities with similar histopathological features and whose origin has not been fully elucidated. The former is reactive and the latter exhibits a nonneoplastic proliferative behavior. This article aims to review the literature on peripheral giant cell lesions (PGCL) and central giant cell lesions (CGCL) by discussing the most important aspects pertaining to each of them. Results: These lesions are found in different locations and show diverse clinical signs despite having the same histopathological features. The treatment consists in the surgical resection by different techniques depending on the type of the lesion and clinical conditions. In the case of CGCL, drug therapy may also be employed. Conclusion: Although there is no consensus in the literature, it is essential to know the etiology of these lesions as well as the exact origin of the giant cells. Due to their singular biological behavior, it is of utmost importance to establish a differential diagnosis between the two lesions and other processes that have similar clinical, radiological and histological characteristics, inasmuch as this procedure is essential to provide a suitable treatment and establish a prognosis.

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Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

“…Previously, the lesion was called peripheral giant cell reparative granuloma. However, its reparative effect has not been proved yet, hence osteoclast activity seems doubtful (11,20,34) .…”

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

Section: Peripheral Giant Cell Lesionsmentioning

confidence: 99%

See 3 more Smart Citations

Peripheral and central giant cell lesions: etiology, origin of giant cells, diagnosis and treatment

Vasconcelos

Vasconcelos²,

Queiroz

2013

J. Bras. Patol. Med. Lab.

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Multiple Large Peripheral Giant Cell Granuloma: A Case Report

Gümüşok

Özle

Seçkin

et al. 2015

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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Objective: KRAS mutation attenuates treatment effect of cetuximab. The purpose of this study was to develop a rapid and specific method to detect KRAS mutation at codon 12 using novel gene amplification methods.Study Design: Previously, loop-mediated isothermal amplification (LAMP) assay was developed to amplify copies of particular DNA sequence. LAMP assay is rapid and specific method rather than polymerase chain reaction process. We modified LAMP assay by using peptide nucleic acid (PNA) to suppress an amplification of wild-type allele.Results: We successfully developed modified LAMP assay in several cultured cell lines. By using this assay, we can amplify DNA fragment of mutated KRAS gene within 20 minutes. Primers bracketing the nucleotides of KRAS codon 12 were designed so that all possible alleles would be amplified by this assay.Conclusions: The modified LAMP assay is a rapid, and highly sensitive detection assay for cancer mutations.

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The Importance of Histopathological Diagnosis in the Management of Lesions Presenting as Peri‐Implantitis

Kaplan

Hirshberg

Shlomi

et al. 2013

Clin Implant Dent Rel Res

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There were no clinical features which could distinguish PI with simple inflammation from potentially destructive lesions mimicking PI, such as GCG, PG, and actinomycosis. However, to control GCG and PG surgical procedures would be recommended, actinomycosis would indicate specific antibiotics, whereas in nonspecific inflammation, these measures may not be indicated. The results of the present study provide evidence for the importance of early microscopic examination of lesions presenting clinically as peri-implantitis, a step toward more accurate diagnosis and improved treatment of PI and lesions mimicking PI.

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Management of an unusual peripheral giant cell granuloma: A diagnostic dilemma

Cited by 19 publications

References 8 publications

Peripheral and central giant cell lesions: etiology, origin of giant cells, diagnosis and treatment

Peripheral and central giant cell lesions: etiology, origin of giant cells, diagnosis and treatment

Multiple Large Peripheral Giant Cell Granuloma: A Case Report

The Importance of Histopathological Diagnosis in the Management of Lesions Presenting as Peri‐Implantitis

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