Osteoma is a benign, slow-growing, painless, discrete lesion which is characterised with the proliferation of a compact or cancellous bone. Osteomas are rare on the jaws. Lesions of the mandible developed most often in the condyle, angle and margin. Osteoma developed on the genial tubercle area had only been reported in one case. A 50-year-old female patient has been admitted to our department with the symptom of a hard mass under the chin area. In extra-oral and radiographic examinations, a 1×1 cm size, round, palpable, immobile, radiopaque mass has been determined on the genial tubercle area. The lesion has been completely removed under local anaesthesia by extra-oral approach. Her recovery period was uneventful. Osteoma diagnosis was confirmed with histopathological examination. There is no recurrence at 3-year follow-up. The purpose of this case report is to present a peripheral osteoma case that occurred in the genial tubercle area which is an unusual place.
Ankaferd Bloodstopper® could be used as a supportive treatment option of cancer in oral and maxillofacial surgery since it possesses chemopreventive effect.
Objective: KRAS mutation attenuates treatment effect of cetuximab. The purpose of this study was to develop a rapid and specific method to detect KRAS mutation at codon 12 using novel gene amplification methods.Study Design: Previously, loop-mediated isothermal amplification (LAMP) assay was developed to amplify copies of particular DNA sequence. LAMP assay is rapid and specific method rather than polymerase chain reaction process. We modified LAMP assay by using peptide nucleic acid (PNA) to suppress an amplification of wild-type allele.Results: We successfully developed modified LAMP assay in several cultured cell lines. By using this assay, we can amplify DNA fragment of mutated KRAS gene within 20 minutes. Primers bracketing the nucleotides of KRAS codon 12 were designed so that all possible alleles would be amplified by this assay.Conclusions: The modified LAMP assay is a rapid, and highly sensitive detection assay for cancer mutations.
Displacement of a foreign body in maxillary sinuses is a common complication in dentistry. However, metallic foreign bodies except dental implants are rarely found in the maxillary sinus. Displaced foreign bodies can cause serious complications and disturb the mucociliary function and this causes potential complications, mainly acute or chronic maxillary sinusitis. This article reported metallic objects penetrating maxillary sinuses of two patients including a membrane fixation screw and a dental burr, as well as their removal with Caldwell-Luc technique. Foreign bodies should be detected and removed on time in order to prevent complications. Otherwise, in advanced stages, the affected area should be reached with Caldwell-Luc operation or endoscopic approaches.
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