Management of Abdominoperineal Excision of the Rectum in a Patient with Glanzmann Thrombasthenia

Buckley, Frances; Norris, Alan; Kerr, R. C.

doi:10.1159/000489114

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…To rule out any primary GI disease endoscopic investigations are usually done [11]. Treatments for symptoms and supportive measures are the main therapeutic approaches for GT [12]. In individuals with GT, gastrointestinal bleeding poses a life-threatening risk.…”

Section: Discussionmentioning

confidence: 99%

Glanzmann's Thrombasthenia with Involuntary Upper and Lower GI Bleeding: A Case Report

Salih,

Ihtisham,

Ullah

et al. 2023

ICMR

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A rarely seen bleeding illness called Glanzmann's thrombasthenia (GT) is inherited via the autosomal recessive gene. Platelet membrane glycoprotein IIb/IIIa (integrin aIIbb3) structural abnormalities and malfunction play a major role in the development of GT. The most prevalent signs of GT are various types of bleeding, including menorrhagia in females, recurrent nasal bleeding, mucocutaneous bleeding, and continuous bleeding after injury or surgery. Some patients may not survive after undergoing such a hemorrhage. It is unusual for GT to experience spontaneous upper and lower gastrointestinal hemorrhages. In this case study, a young boy with accidental bleeding in vomitus and fresh blood in his stool was hospitalized. His primary GT is an uncommon autosomal recessive genetic condition characterized by dysfunctional platelet aggregation symptoms that were sporadic and recurring chronic fresh blood in his stool. Blood dripped from the stomach body wall during the gastroscopy. However, except for petechiae no visible lesions were discovered, like erosion or ulceration. Further investigations revealed that the patient's BT and CT were prolonged and platelet aggregation was poor. After receiving aggressive treatment, the patient showed clinical improvement and was eventually diagnosed with GT.

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Section: Discussionmentioning

confidence: 99%

Glanzmann's Thrombasthenia with Involuntary Upper and Lower GI Bleeding: A Case Report

Salih,

Ihtisham,

Ullah

et al. 2023

ICMR

View full text Add to dashboard Cite

show abstract

“…13 The major therapeutic methods of GT are symptomatic and supportive treatments. 14 Gastrointestinal bleeding is a potentially life-threatening condition in patients with GT. The bleeding in our patient was stopped by endoscopic therapy, drug hemostasis, and other active measures; thus, our treatments were successful.…”

Section: Discussionmentioning

confidence: 99%

Glanzmann’s thrombasthenia with spontaneous upper gastrointestinal bleeding: a case report

Qiao¹,

Chen²,

Shi³

et al. 2020

J Int Med Res

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Glanzmann's thrombasthenia (GT) is a rare bleeding disorder inherited in an autosomal recessive manner. The pathogenesis of GT mainly involves structural abnormalities and dysfunction of platelet membrane glycoprotein IIb/IIIa (integrin aIIbb3). The most common symptoms of GT are various types of bleeding, including recurrent nasal bleeding, mucocutaneous bleeding, unremitting bleeding after injury or operation, and menorrhea in women. Such hemorrhage may be fatal in some patients. GT with spontaneous upper gastrointestinal bleeding is relatively rare. In the present report, we describe a middle-aged man who was hospitalized with spontaneous upper gastrointestinal bleeding. His main symptom was recurrent chronic and intermittent melena. Gastroscopy revealed oozing of blood in the gastric antrum wall. However, no obvious lesions such as erosion or ulceration were found. Upon further inspection, we found that the patient's platelet aggregation was poor, and flow cytometry assay revealed low expression of platelet membrane integrin aIIbb3. The patient was eventually diagnosed with GT and exhibited clinical improvement after active treatment.

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Management of Abdominoperineal Excision of the Rectum in a Patient with Glanzmann Thrombasthenia

Cited by 2 publications

References 15 publications

Glanzmann's Thrombasthenia with Involuntary Upper and Lower GI Bleeding: A Case Report

Glanzmann's Thrombasthenia with Involuntary Upper and Lower GI Bleeding: A Case Report

Glanzmann’s thrombasthenia with spontaneous upper gastrointestinal bleeding: a case report

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